View source for STBT5:Bone metastases

{{DISPLAYTITLE:Bone metastases}}

[[STBT5:Table_of_Contents|Soft Tissue and Bone Tumours (Who Classification, 5th ed.)]]

<br />
==Primary Author(s)*==
Kathleen Schieffer, PhD, FACMG
==WHO Classification of Disease==

{| class="wikitable"
!Structure
!Disease
|-
|Book
|Soft Tissue and Bone Tumours (5th ed.)
|-
|Category
|Bone tumours
|-
|Family
|Other mesenchymal tumours of bone
|-
|Type
|Bone metastases
|-
|Subtype(s)
|N/A
|}

==Related Terminology==

{| class="wikitable"
|+
|Acceptable
|N/A
|-
|Not Recommended
|N/A
|}

==Gene Rearrangements==
None, genetics of primary tumor should be evaluated
{| class="wikitable sortable"
|-
!Driver Gene!!Fusion(s) and Common Partner Genes!!Molecular Pathogenesis!!Typical Chromosomal Alteration(s)
!Prevalence -Common >20%, Recurrent 5-20% or Rare <5% (Disease)
!Diagnostic, Prognostic, and Therapeutic Significance - D, P, T
!Established Clinical Significance Per Guidelines - Yes or No (Source)
!Clinical Relevance Details/Other Notes
|-
|N/A
|N/A
|N/A
|N/A
|N/A
|N/A
|N/A
|N/A
|}
==Individual Region Genomic Gain/Loss/LOH==
None, genetics of primary tumor should be evaluated
{| class="wikitable sortable"
|-
!Chr #!!Gain, Loss, Amp, LOH!!Minimal Region Cytoband and/or Genomic Coordinates [Genome Build; Size]!!Relevant Gene(s)
!Diagnostic, Prognostic, and Therapeutic Significance - D, P, T
!Established Clinical Significance Per Guidelines - Yes or No (Source)
!Clinical Relevance Details/Other Notes
|-
|N/A
|N/A
|N/A
|N/A
|N/A
|N/A
|N/A
|}
==Characteristic Chromosomal or Other Global Mutational Patterns==
None, genetics of primary tumor should be evaluated
{| class="wikitable sortable"
|-
!Chromosomal Pattern
!Molecular Pathogenesis
!Prevalence - 
Common >20%, Recurrent 5-20% or Rare <5% (Disease)
!Diagnostic, Prognostic, and Therapeutic Significance - D, P, T
!Established Clinical Significance Per Guidelines - Yes or No (Source)
!Clinical Relevance Details/Other Notes
|-
|N/A
|N/A
|N/A
|N/A
|N/A
|N/A
|}
==Gene Mutations (SNV/INDEL)==
None, genetics of primary tumor should be evaluated
{| class="wikitable sortable"
|-
!Gene!!Genetic Alteration!!Tumor Suppressor Gene, Oncogene, Other!!Prevalence -
Common >20%, Recurrent 5-20% or Rare <5% (Disease)
!Diagnostic, Prognostic, and Therapeutic Significance - D, P, T  
!Established Clinical Significance Per Guidelines - Yes or No (Source)
!Clinical Relevance Details/Other Notes
|-
|N/A
|N/A
|N/A
|N/A
|N/A
|N/A
|N/A
|}Note: A more extensive list of mutations can be found in [https://www.cbioportal.org/ <u>cBioportal</u>], [https://cancer.sanger.ac.uk/cosmic <u>COSMIC</u>], and/or other databases. When applicable, gene-specific pages within the CCGA site directly link to pertinent external content.
==Epigenomic Alterations==
None, epigenetics of primary tumor should be evaluated
==Genes and Main Pathways Involved==
None, genetics of primary tumor should be evaluated
{| class="wikitable sortable"
|-
!Gene; Genetic Alteration!!Pathway!!Pathophysiologic Outcome
|-
|N/A
|N/A
|N/A
|}
==Genetic Diagnostic Testing Methods==
None, genetics of primary tumor should be evaluated
==Familial Forms==
Not applicable
==Additional Information==
Not applicable
==Links==
None
==References==
None
<references />

==Notes==
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the [[Leadership|''<u>Associate Editor</u>'']] or other CCGA representative.  When pages have a major update, the new author will be acknowledged at the beginning of the page, and those who contributed previously will be acknowledged below as a prior author. 

Prior Author(s):
<nowiki>*</nowiki>''Citation of this Page'': “Bone metastases”. Compendium of Cancer Genome Aberrations (CCGA), Cancer Genomics Consortium (CGC), updated {{REVISIONMONTH}}/{{REVISIONDAY}}/{{REVISIONYEAR}}, <nowiki>https://ccga.io/index.php/STBT5:Bone metastases</nowiki>.
[[Category:STBT5]]
[[Category:DISEASE]]
[[Category:Diseases B]]