BRST5:Fibroadenoma - Revision history

Richard.Glen at 00:51, 26 February 2026

2026-02-26T00:51:32Z

← Older revision		Revision as of 19:51, 25 February 2026
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	https://www.pathologyoutlines.com/topic/breastfibroadenoma.html		https://www.pathologyoutlines.com/topic/breastfibroadenoma.html
	==References==		==References==
	<br /><references />		<br />
			<references />

	==Notes==		==Notes==

Richard.Glen at 00:47, 26 February 2026

2026-02-26T00:47:10Z

← Older revision		Revision as of 19:47, 25 February 2026
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	https://www.pathologyoutlines.com/topic/breastfibroadenoma.html		https://www.pathologyoutlines.com/topic/breastfibroadenoma.html
	==References==		==References==
	<br />		<br /><references />

	==Notes==		==Notes==
	<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the [[Leadership\|''<u>Associate Editor</u>'']] or other CCGA representative. When pages have a major update, the new author will be acknowledged at the beginning of the page, and those who contributed previously will be acknowledged below as a prior author.		<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the [[Leadership\|''<u>Associate Editor</u>'']] or other CCGA representative. When pages have a major update, the new author will be acknowledged at the beginning of the page, and those who contributed previously will be acknowledged below as a prior author.
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	[[Category:DISEASE]]		[[Category:DISEASE]]
	[[Category:Diseases F]]		[[Category:Diseases F]]
	~~<references />~~

Bailey.Glen at 17:46, 3 July 2025

2025-07-03T17:46:46Z

← Older revision		Revision as of 12:46, 3 July 2025
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	\|}		\|}

	~~==WHO Essential and Desirable Genetic Diagnostic Criteria==~~
	~~{\| class="wikitable"~~
	\|+
	\|WHO Essential Criteria (Genetics)*
	\|
	\|-
	\|WHO Desirable Criteria (Genetics)*
	\|
	\|-
	~~\|Other Classification~~
	\|
	\|}
	<nowiki>*</nowiki>Note: These are only the genetic/genomic criteria. Additional diagnostic criteria can be found in the [https://tumourclassification.iarc.who.int/home <u>WHO Classification of Tumours</u>].
	==Related Terminology==		==Related Terminology==

Bailey.Glen at 22:07, 25 May 2025

2025-05-25T22:07:07Z

← Older revision		Revision as of 17:07, 25 May 2025
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	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	\|-		\|-
	!Chr #!!~~'''~~Gain, Loss, Amp, LOH~~'''~~!!~~'''~~Minimal Region Cytoband and/or Genomic Coordinates [Genome Build; Size]~~'''~~!!~~'''~~Relevant Gene(s)~~'''~~		!Chr #!!Gain, Loss, Amp, LOH!!Minimal Region Cytoband and/or Genomic Coordinates [Genome Build; Size]!!Relevant Gene(s)
	!~~'''~~Diagnostic, Prognostic, and Therapeutic Significance - D, P, T~~'''~~		!Diagnostic, Prognostic, and Therapeutic Significance - D, P, T
	!~~'''~~Established Clinical Significance Per Guidelines - Yes or No (Source)~~'''~~		!Established Clinical Significance Per Guidelines - Yes or No (Source)
	!~~'''~~Clinical Relevance Details/Other Notes~~'''~~		!Clinical Relevance Details/Other Notes
	\|-		\|-
	\|		\|
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	!Chromosomal Pattern		!Chromosomal Pattern
	!Molecular Pathogenesis		!Molecular Pathogenesis
	!~~'''~~Prevalence -~~'''~~		!Prevalence -
	~~'''~~Common >20%, Recurrent 5-20% or Rare <5% (Disease)~~'''~~		Common >20%, Recurrent 5-20% or Rare <5% (Disease)
	!~~'''~~Diagnostic, Prognostic, and Therapeutic Significance - D, P, T~~'''~~		!Diagnostic, Prognostic, and Therapeutic Significance - D, P, T
	!~~'''~~Established Clinical Significance Per Guidelines - Yes or No (Source)~~'''~~		!Established Clinical Significance Per Guidelines - Yes or No (Source)
	!~~'''~~Clinical Relevance Details/Other Notes~~'''~~		!Clinical Relevance Details/Other Notes
	\|-		\|-
	\|		\|
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	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	\|-		\|-
	!Gene!!~~'''~~Genetic Alteration~~'''~~!!~~'''~~Tumor Suppressor Gene, Oncogene, Other~~'''~~!!~~'''~~Prevalence -~~'''~~		!Gene!!Genetic Alteration!!Tumor Suppressor Gene, Oncogene, Other!!Prevalence -
	~~'''~~Common >20%, Recurrent 5-20% or Rare <5% (Disease)~~'''~~		Common >20%, Recurrent 5-20% or Rare <5% (Disease)
	!~~'''~~Diagnostic, Prognostic, and Therapeutic Significance - D, P, T ~~'''~~		!Diagnostic, Prognostic, and Therapeutic Significance - D, P, T
	!~~'''~~Established Clinical Significance Per Guidelines - Yes or No (Source)~~'''~~		!Established Clinical Significance Per Guidelines - Yes or No (Source)
	!~~'''~~Clinical Relevance Details/Other Notes~~'''~~		!Clinical Relevance Details/Other Notes
	\|-		\|-
	\|''MED12''		\|''MED12''

Bailey.Glen at 20:29, 25 May 2025

2025-05-25T20:29:25Z

← Older revision		Revision as of 15:29, 25 May 2025
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	<nowiki>*</nowiki>Note: These are only the genetic/genomic criteria. Additional diagnostic criteria can be found in the [https://tumourclassification.iarc.who.int/home <u>WHO Classification of Tumours</u>].		<nowiki>*</nowiki>Note: These are only the genetic/genomic criteria. Additional diagnostic criteria can be found in the [https://tumourclassification.iarc.who.int/home <u>WHO Classification of Tumours</u>].
	==Related Terminology==		==Related Terminology==

	{\| class="wikitable"		{\| class="wikitable"
	\|+		\|+
	\|Acceptable		\|Acceptable
	\|		\|N/A
	\|-		\|-
	\|Not Recommended		\|Not Recommended
	\|		\|Adenofibroma
	\|}		\|}

Kgeiersbach at 23:05, 1 May 2025

2025-05-01T23:05:37Z

← Older revision		Revision as of 18:05, 1 May 2025
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	\|}Note: A more extensive list of mutations can be found in [https://www.cbioportal.org/ <u>cBioportal</u>], [https://cancer.sanger.ac.uk/cosmic <u>COSMIC</u>], and/or other databases. When applicable, gene-specific pages within the CCGA site directly link to pertinent external content.		\|}Note: A more extensive list of mutations can be found in [https://www.cbioportal.org/ <u>cBioportal</u>], [https://cancer.sanger.ac.uk/cosmic <u>COSMIC</u>], and/or other databases. When applicable, gene-specific pages within the CCGA site directly link to pertinent external content.
	==Epigenomic Alterations==		==Epigenomic Alterations==
	~~Put your text here~~		<br />
	==Genes and Main Pathways Involved==		==Genes and Main Pathways Involved==
	~~Put your text here and fill in the table <span style="color:#0070C0">(''Instructions: Please include references throughout the table. Do not delete the table.)''~~</~~span~~>		<br />
	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	\|-		\|-
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	\|}		\|}
	==Genetic Diagnostic Testing Methods==		==Genetic Diagnostic Testing Methods==
	<br />		Next generation sequencing, PCR based testing with Sanger sequencing.<br />
	==Familial Forms==		==Familial Forms==
	<br />		Women with Carney complex due to an inherited pathogenic variant in PRKAR1A can develop myxoid fibroadenomas, which appear genetically distinct from conventional fibroadenomas.<ref>{{Cite journal\|last=Carney\|first=J. A.\|last2=Toorkey\|first2=B. C.\|date=1991-08\|title=Myxoid fibroadenoma and allied conditions (myxomatosis) of the breast. A heritable disorder with special associations including cardiac and cutaneous myxomas\|url=https://pubmed.ncbi.nlm.nih.gov/2069209\|journal=The American Journal of Surgical Pathology\|volume=15\|issue=8\|pages=713–721\|doi=10.1097/00000478-199108000-00001\|issn=0147-5185\|pmid=2069209}}</ref><ref>{{Cite journal\|last=Lozada\|first=John R.\|last2=Burke\|first2=Kathleen A.\|last3=Maguire\|first3=Aoife\|last4=Pareja\|first4=Fresia\|last5=Lim\|first5=Raymond S.\|last6=Kim\|first6=Jisun\|last7=Gularte-Merida\|first7=Rodrigo\|last8=Murray\|first8=Melissa P.\|last9=Brogi\|first9=Edi\|date=2017-10\|title=Myxoid fibroadenomas differ from conventional fibroadenomas: a hypothesis-generating study\|url=https://pubmed.ncbi.nlm.nih.gov/28513873\|journal=Histopathology\|volume=71\|issue=4\|pages=626–634\|doi=10.1111/his.13258\|issn=1365-2559\|pmc=5597459\|pmid=28513873}}</ref> Beckwith-Wiedemann syndrome has been associated with the development of fibroadenomas in young patients.<ref>{{Cite journal\|last=Poh\|first=Melissa M.\|last2=Ballard\|first2=Tiffany N.\|last3=Wendel\|first3=J. Jason\|date=2010-06\|title=Beckwith-Wiedemann syndrome and juvenile fibroadenoma: a case report\|url=https://pubmed.ncbi.nlm.nih.gov/20506580\|journal=Annals of Plastic Surgery\|volume=64\|issue=6\|pages=803–806\|doi=10.1097/sap.0b013e3181b025f6\|issn=1536-3708\|pmid=20506580}}</ref><ref>{{Cite journal\|last=Raine\|first=P. A.\|last2=Noblett\|first2=H. R.\|last3=Houghton-Allen\|first3=B. W.\|last4=Campbell\|first4=P. E.\|date=1979-04\|title=Breast fibroadenoma and cardiac anomaly associated with EMG (Beckwith-Wiedemann) syndrome\|url=https://pubmed.ncbi.nlm.nih.gov/430311\|journal=The Journal of Pediatrics\|volume=94\|issue=4\|pages=633–634\|doi=10.1016/s0022-3476(79)80039-6\|issn=0022-3476\|pmid=430311}}</ref><br />
	==Additional Information==		==Additional Information==
	<br />		<br />
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	[[Category:DISEASE]]		[[Category:DISEASE]]
	[[Category:Diseases F]]		[[Category:Diseases F]]
			<references />

Kgeiersbach: updated content

2025-05-01T22:52:14Z

updated content

Show changes

Bailey.Glen at 18:11, 24 March 2025

2025-03-24T18:11:14Z

← Older revision		Revision as of 13:11, 24 March 2025
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			{{DISPLAYTITLE:Fibroadenoma}}
			[[BRST5:Table_of_Contents\|Breast Tumours (WHO Classification, 5th ed.)]]

			{{Under Construction}}

	<span style="color:#0070C0">(''General Instructions – The focus of these pages is the clinically significant genetic alterations in each disease type. This is based on up-to-date knowledge from multiple resources such as PubMed and the WHO classification books. The CCGA is meant to be a supplemental resource to the WHO classification books; the CCGA captures in a continually updated wiki-stye manner the current genetics/genomics knowledge of each disease, which evolves more rapidly than books can be revised and published. If the same disease is described in multiple WHO classification books, the genetics-related information for that disease will be consolidated into a single main page that has this template (other pages would only contain a link to this main page). Use [https://www.genenames.org/ <u>HUGO-approved gene names and symbols</u>] (italicized when appropriate), [https://varnomen.hgvs.org/ <u>HGVS-based nomenclature for variants</u>], as well as generic names of drugs and testing platforms or assays if applicable. Please complete tables whenever possible and do not delete them (add N/A if not applicable in the table and delete the examples); to add (or move) a row or column in a table, click nearby within the table and select the > symbol that appears. Please do not delete or alter the section headings. The use of bullet points alongside short blocks of text rather than only large paragraphs is encouraged. Additional instructions below in italicized blue text should not be included in the final page content. Please also see'' </span><u>''[[Author_Instructions]]''</u><span style="color:#0070C0"> ''and [[Frequently Asked Questions (FAQs)\|<u>FAQs</u>]] as well as contact your [[Leadership\|<u>Associate Editor</u>]] or [mailto:CCGA@cancergenomics.org <u>Technical Support</u>].)''</span>		<span style="color:#0070C0">(''General Instructions – The focus of these pages is the clinically significant genetic alterations in each disease type. This is based on up-to-date knowledge from multiple resources such as PubMed and the WHO classification books. The CCGA is meant to be a supplemental resource to the WHO classification books; the CCGA captures in a continually updated wiki-stye manner the current genetics/genomics knowledge of each disease, which evolves more rapidly than books can be revised and published. If the same disease is described in multiple WHO classification books, the genetics-related information for that disease will be consolidated into a single main page that has this template (other pages would only contain a link to this main page). Use [https://www.genenames.org/ <u>HUGO-approved gene names and symbols</u>] (italicized when appropriate), [https://varnomen.hgvs.org/ <u>HGVS-based nomenclature for variants</u>], as well as generic names of drugs and testing platforms or assays if applicable. Please complete tables whenever possible and do not delete them (add N/A if not applicable in the table and delete the examples); to add (or move) a row or column in a table, click nearby within the table and select the > symbol that appears. Please do not delete or alter the section headings. The use of bullet points alongside short blocks of text rather than only large paragraphs is encouraged. Additional instructions below in italicized blue text should not be included in the final page content. Please also see'' </span><u>''[[Author_Instructions]]''</u><span style="color:#0070C0"> ''and [[Frequently Asked Questions (FAQs)\|<u>FAQs</u>]] as well as contact your [[Leadership\|<u>Associate Editor</u>]] or [mailto:CCGA@cancergenomics.org <u>Technical Support</u>].)''</span>
	==Primary Author(s)*==		==Primary Author(s)*==
	Put your text here<span style="color:#0070C0"> (''<span class="blue-text">EXAMPLE:</span>'' Jane Smith, PhD) </span>		Put your text here<span style="color:#0070C0"> (''<span class="blue-text">EXAMPLE:</span>'' Jane Smith, PhD) </span>
	==WHO Classification of Disease==		==WHO Classification of Disease==
	~~<span style="color:#0070C0">(''Instructions: This table’s content from the WHO book will be <u>autocompleted</u>.'')</span>~~
	{\| class="wikitable"		{\| class="wikitable"
	!Structure		!Structure
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	\|-		\|-
	\|Book		\|Book
	\|		\|Breast Tumours (5th ed.)
	\|-		\|-
	\|Category		\|Category
	\|		\|Fibroepithelial tumours and hamartomas of the breast
	\|-		\|-
	\|Family		\|Family
	\|		\|Fibroepithelial tumours and hamartomas of the breast: Introduction
	\|-		\|-
	\|Type		\|Type
	\|		\|Fibroadenoma
	\|-		\|-
	\|Subtype(s)		\|Subtype(s)
	\|		\|N/A
	\|}		\|}

	==WHO Essential and Desirable Genetic Diagnostic Criteria==		==WHO Essential and Desirable Genetic Diagnostic Criteria==
	<span style="color:#0070C0">(''Instructions: The table will have the diagnostic criteria from the WHO book <u>autocompleted</u>; remove any <u>non</u>-genetics related criteria. If applicable, add text about other classification'' ''systems that define this entity and specify how the genetics-related criteria differ.'')</span>		<span style="color:#0070C0">(''Instructions: The table will have the diagnostic criteria from the WHO book <u>autocompleted</u>; remove any <u>non</u>-genetics related criteria. If applicable, add text about other classification'' ''systems that define this entity and specify how the genetics-related criteria differ.'')</span>
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	<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the [[Leadership\|''<u>Associate Editor</u>'']] or other CCGA representative. When pages have a major update, the new author will be acknowledged at the beginning of the page, and those who contributed previously will be acknowledged below as a prior author.		<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the [[Leadership\|''<u>Associate Editor</u>'']] or other CCGA representative. When pages have a major update, the new author will be acknowledged at the beginning of the page, and those who contributed previously will be acknowledged below as a prior author.

	Prior Author(s):		Prior Author(s):
			<nowiki>*</nowiki>''Citation of this Page'': “Fibroadenoma”. Compendium of Cancer Genome Aberrations (CCGA), Cancer Genomics Consortium (CGC), updated {{REVISIONMONTH}}/{{REVISIONDAY}}/{{REVISIONYEAR}}, <nowiki>https://ccga.io/index.php/BRST5:Fibroadenoma</nowiki>.
			[[Category:BRST5]][[Category:DISEASE]][[Category:Diseases F]]

Jennelleh at 20:06, 18 December 2024

2024-12-18T20:06:25Z

Show changes

Jennelleh: Jennelleh moved page Fibroadenoma to BRST5:Fibroadenoma without leaving a redirect: Moved to GTS5 version

2024-02-29T18:26:55Z

Jennelleh moved page Fibroadenoma to BRST5:Fibroadenoma without leaving a redirect: Moved to GTS5 version

← Older revision		Revision as of 13:26, 29 February 2024
(No difference)