GTS5:Table of Contents - Revision history

Bailey.Glen at 15:58, 5 June 2025

2025-06-05T15:58:25Z

← Older revision		Revision as of 10:58, 5 June 2025
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	- [[GTS5:Hereditary leiomyomatosis and renal cell carcinoma syndrome (FH)]]		- [[GTS5:Hereditary leiomyomatosis and renal cell carcinoma syndrome (FH)]]

	'''Toxic metabolite-mediated disorders'''		'''Toxic metabolite-mediated disorders'''
	- [[GTS5:Hereditary tyrosinaemia type 1 (FAH)]]		- [[GTS5:Hereditary tyrosinaemia type 1 (FAH)]]

Bailey.Glen at 15:57, 5 June 2025

2025-06-05T15:57:44Z

← Older revision		Revision as of 10:57, 5 June 2025
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	- [[GTS5:Activated Phosphatidylinositol-3-OH kinase δ Syndrome - APDS (PIK3CD)]]		- [[GTS5:Activated Phosphatidylinositol-3-OH kinase δ Syndrome - APDS (PIK3CD)]]

	'''Transcription factors and regulators'''		'''Transcription factors and regulators'''

	- [[GTS5:Multiple endocrine neoplasia type 5, MAX related tumours (MAX)]]		- [[GTS5:Multiple endocrine neoplasia type 5, MAX related tumours (MAX)]]
	- [[GTS5:MAFA-related familial insulinomatosis (MAFA)]]		- [[GTS5:MAFA-related familial insulinomatosis (MAFA)]]
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	==Oxidative stress response and metabolism ([[GTS5:Oxidative stress response and metabolism\|Overview Page Link]])==		==Oxidative stress response and metabolism ([[GTS5:Oxidative stress response and metabolism\|Overview Page Link]])==

	'''Angiogenesis'''		'''Angiogenesis'''
	- [[GTS5:Von Hippel-Lindau syndrome (VHL)]]		- [[GTS5:Von Hippel-Lindau syndrome (VHL)]]

Bailey.Glen at 15:57, 5 June 2025

2025-06-05T15:57:21Z

← Older revision		Revision as of 10:57, 5 June 2025
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	'''Homologous recombination'''		'''Homologous recombination'''

	- [[GTS5:BRCA-related cancer predisposition syndrome (BRCA1, BRCA2)]]		- [[GTS5:BRCA-related cancer predisposition syndrome (BRCA1, BRCA2)]]
	- [[GTS5:PALB2-related cancer predisposition syndrome (PALB2)]]		- [[GTS5:PALB2-related cancer predisposition syndrome (PALB2)]]
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	==Telomere maintenance ([[GTS5:Telomere maintenance\|Overview Page Link]])==		==Telomere maintenance ([[GTS5:Telomere maintenance\|Overview Page Link]])==

	'''Telomere biology disorders'''		'''Telomere biology disorders'''
	- [[GTS5:Dyskeratosis congenita (DKC1, TERT, TERC, TINF2, Other IBMFS genes)]]		- [[GTS5:Dyskeratosis congenita (DKC1, TERT, TERC, TINF2, Other IBMFS genes)]]

Bailey.Glen at 15:55, 5 June 2025

2025-06-05T15:55:41Z

← Older revision		Revision as of 10:55, 5 June 2025
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	==Cell cycle and apoptosis pathways ([[GTS5:Cell cycle and apoptosis pathways\|Overview Page Link]])==		==Cell cycle and apoptosis pathways ([[GTS5:Cell cycle and apoptosis pathways\|Overview Page Link]])==

	'''P53 pathway'''		'''P53 pathway'''
	- [[GTS5:Li-Fraumeni syndrome (TP53)]]		- [[GTS5:Li-Fraumeni syndrome (TP53)]]

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	==DNA repair and genomic stability ([[GTS5:DNA repair and genomic stability\|Overview Page Link]])==		==DNA repair and genomic stability ([[GTS5:DNA repair and genomic stability\|Overview Page Link]])==

	'''Mismatch repair'''		'''Mismatch repair'''
	- [[GTS5:Lynch Syndrome (MLH1, PMS2, MSH2, MSH6)]]		- [[GTS5:Lynch Syndrome (MLH1, PMS2, MSH2, MSH6)]]
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	==Telomere maintenance ([[GTS5:Telomere maintenance\|Overview Page Link]])==		==Telomere maintenance ([[GTS5:Telomere maintenance\|Overview Page Link]])==

	'''Telomere biology disorders'''		'''Telomere biology disorders'''
	- [[GTS5:Dyskeratosis congenita (DKC1, TERT, TERC, TINF2, Other IBMFS genes)]]		- [[GTS5:Dyskeratosis congenita (DKC1, TERT, TERC, TINF2, Other IBMFS genes)]]
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	==Epigenetic drivers and chromatin remodelling ([[GTS5:pigenetic drivers and chromatin remodelling\|Overview Page Link]])==		==Epigenetic drivers and chromatin remodelling ([[GTS5:pigenetic drivers and chromatin remodelling\|Overview Page Link]])==

	'''Imprinting disorders'''		'''Imprinting disorders'''
	- [[GTS5:Beckwith-Wiedemann spectrum (IGF2; CDKN1C)]]		- [[GTS5:Beckwith-Wiedemann spectrum (IGF2; CDKN1C)]]

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	==RNA regulation ([[GTS5:RNA regulation\|Overview Page Link]])==		==RNA regulation ([[GTS5:RNA regulation\|Overview Page Link]])==

	'''MicroRNA'''		'''MicroRNA'''
	- [[GTS5:DICER1-related tumour predisposition syndrome (DICER1)]]		- [[GTS5:DICER1-related tumour predisposition syndrome (DICER1)]]
	- [[GTS5:MicroRNA processor tumour predisposition syndromes (DROSHA, DGCR8)]]		- [[GTS5:MicroRNA processor tumour predisposition syndromes (DROSHA, DGCR8)]]
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	==Protein regulation ([[GTS5:Protein regulation\|Overview Page Link]])==		==Protein regulation ([[GTS5:Protein regulation\|Overview Page Link]])==

	'''Ubiquitin pathway'''		'''Ubiquitin pathway'''
	- [[GTS5:BAP1-related tumour predisposition syndrome (BAP1)]]		- [[GTS5:BAP1-related tumour predisposition syndrome (BAP1)]]

Bailey.Glen at 15:54, 5 June 2025

2025-06-05T15:54:52Z

← Older revision		Revision as of 10:54, 5 June 2025
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	- [[GTS5:Carney complex (PRKAR1A, PDE8B, PDE11A)]]		- [[GTS5:Carney complex (PRKAR1A, PDE8B, PDE11A)]]
	- [[GTS5:PROS syndrome (PIK3CA)]]		- [[GTS5:PROS syndrome (PIK3CA)]]

	'''WNT/TGFbeta pathway'''		'''WNT/TGFbeta pathway'''
	- [[GTS5:Familial adenomatous polyposis (APC)]]		- [[GTS5:Familial adenomatous polyposis (APC)]]

Bailey.Glen at 15:54, 5 June 2025

2025-06-05T15:54:36Z

← Older revision		Revision as of 10:54, 5 June 2025
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	- [[GTS5:Carney complex (PRKAR1A, PDE8B, PDE11A)]]		- [[GTS5:Carney complex (PRKAR1A, PDE8B, PDE11A)]]
	- [[GTS5:PROS syndrome (PIK3CA)]]		- [[GTS5:PROS syndrome (PIK3CA)]]

	'''WNT/TGFbeta pathway'''		'''WNT/TGFbeta pathway'''

	- [[GTS5:Familial adenomatous polyposis (APC)]]		- [[GTS5:Familial adenomatous polyposis (APC)]]
	- [[GTS5:Gastric Adenocarcinoma and Proximal Polyposis of Stomach - GAPPS (APC promoter)]]		- [[GTS5:Gastric Adenocarcinoma and Proximal Polyposis of Stomach - GAPPS (APC promoter)]]

Bailey.Glen at 15:54, 5 June 2025

2025-06-05T15:54:15Z

← Older revision		Revision as of 10:54, 5 June 2025
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	==Growth factor receptors and related signalling pathways ([[GTS5:Growth factor receptors and related signalling pathways\|Overview Page Link]])==		==Growth factor receptors and related signalling pathways ([[GTS5:Growth factor receptors and related signalling pathways\|Overview Page Link]])==

	'''Growth factor receptors'''		'''Growth factor receptors'''
	- [[GTS5:Hereditary papillary renal carcinoma (MET)]]		- [[GTS5:Hereditary papillary renal carcinoma (MET)]]
	- [[GTS5:Multiple endocrine neoplasia type 2 (RET)]]		- [[GTS5:Multiple endocrine neoplasia type 2 (RET)]]

Bailey.Glen at 15:52, 5 June 2025

2025-06-05T15:52:36Z

Show changes

Bailey.Glen: Created page with "==Growth factor receptors and related signalling pathways (Overview Page Link)== '''Growth factor receptors'''..."

2025-06-05T15:49:17Z

Created page with "==Growth factor receptors and related signalling pathways (Overview Page Link)== '''Growth factor receptors'''..."

New page

==Growth factor receptors and related signalling pathways ([[GTS5:Growth factor receptors and related signalling pathways|Overview Page Link]])==
'''Growth factor receptors'''

- [[GTS5:Hereditary papillary renal carcinoma (MET)]]

- [[GTS5:Multiple endocrine neoplasia type 2 (RET)]]

- [[GTS5:Juvenile polyposis syndrome (BMPR1A, SMAD4)]]

- [[GTS5:Hereditary neuroblastoma (ALK, PHOX2B)]]

- [[GTS5:Encephalocraniocutaneous lipomatosis (FGFR1)]]

'''G-coupled protein receptor pathway'''

- [[GTS5:Glucagon cell hyperplasia and neoplasia (GCGR)]]

- [[GTS5:McCune-Albright syndrome (GNAS)]]

- [[GTS5:Sturge-Weber syndrome (GNAQ)]]

'''RAS-MAPK pathway'''

- [[GTS5:Neurofibromatosis type 1 (NF1)]]

- [[GTS5:NF2-related schwannomatosis (NF2)]]

- [[GTS5:Costello syndrome (HRAS)]]

- [[GTS5:Noonan syndrome (Various genes)]]

- [[GTS5:Schimmelpenning-Feuerstein-Mims (HRAS, KRAS)]]

'''PKA signalling pathway'''

- [[GTS5:Carney complex (PRKAR1A, PDE8B, PDE11A)]]

- [[GTS5:PROS syndrome (PIK3CA)]]

'''WNT/TGFbeta pathway'''

- [[GTS5:Familial adenomatous polyposis (APC)]]

- [[GTS5:Gastric Adenocarcinoma and Proximal Polyposis of Stomach - GAPPS (APC promoter)]]

- [[GTS5:AXIN2-associated polyposis (AXIN2)]]

- [[GTS5:Serrated polyposis (RNF43)]]

- [[GTS5:WT1 related tumour predisposition syndrome (WT1)]]

- [[GTS5:WAGR syndrome (WT1)]]

- [[GTS5:Multiple endocrine neoplasia type 1 (MEN1)]]

- [[GTS5:Peutz-Jeghers syndrome (STK11)]]

- [[GTS5:Hereditary gastric and breast cancer syndrome (CDH1, CTNNA1)]]

- [[GTS5:Hereditary mixed polyposis syndrome (GREM1)]]

'''Hedgehog signalling pathway'''

- [[GTS5:Naevoid basal cell carcinoma syndrome - Gorlin syndrome (PTCH1, SUFU, GPR161)]]

- [[GTS5:SMO-related Curry-Jones syndrome (SMO)]]

- [[GTS5:ELP1-related medulloblastoma predisposition syndrome(ELP1)]]

- [[GTS5:Osteochondromatosis (EXT1, EXT2)]]

'''NF-kB signalling pathway'''

- [[GTS5:Brooke-Spiegler syndrome (CYLD)]]

'''MTOR and PI3K pathway'''

- [[GTS5:Tuberous sclerosis (TSC1, TSC1)]]

- [[GTS5:PTEN hamartoma tumour syndrome (PTEN)]]

- [[GTS5:Activated Phosphatidylinositol-3-OH kinase δ Syndrome - APDS (PIK3CD)]]

'''Transcription factors and regulators'''

- [[GTS5:Multiple endocrine neoplasia type 5, MAX related tumours (MAX)]]

- [[GTS5:MAFA-related familial insulinomatosis (MAFA)]]

- [[GTS5:Birt-Hogg-Dube syndrome (FLCN)]]

- [[GTS5:Familial chordoma (TBXT)]]

- [[GTS5:Hyperparathyroidism jaw tumour syndrome (CDC73)]]

==Oxidative stress response and metabolism ([[GTS5:Oxidative stress response and metabolism|Overview Page Link]])==
'''Angiogenesis'''

- [[GTS5:Von Hippel-Lindau syndrome (VHL)]]

'''Krebs cycle'''

- [[GTS5:SDH-deficient tumour syndrome - Hereditary phaeochromocytoma-paraganglioma syndromes (SDHA, SDHB, SDHC, SDHD, SDHAF2)]]

- [[GTS5:Hereditary leiomyomatosis and renal cell carcinoma syndrome (FH)]]

'''Toxic metabolite-mediated disorders'''

- [[GTS5:Hereditary tyrosinaemia type 1 (FAH)]]

==Cell cycle and apoptosis pathways ([[GTS5:Cell cycle and apoptosis pathways|Overview Page Link]])==
'''P53 pathway'''

- [[GTS5:Li-Fraumeni syndrome (TP53)]]

'''RB pathway'''

- [[GTS5:Retinoblastoma syndrome (RB1)]]

- [[GTS5:Multiple endocrine neoplasia type 4 (CDKN1B)]]

- [[GTS5:CDKN2A-related tumour predisposition syndrome (CDKN2A)]]

- [[GTS5:CDK4-related melanoma predisposition syndrome (CDK4)]]

'''FAS pathway'''

- [[GTS5:Autoimmune lymphoproliferative syndrome (FAS)]]

==DNA repair and genomic stability ([[GTS5:DNA repair and genomic stability|Overview Page Link]])==
'''Mismatch repair'''

- [[GTS5:Lynch Syndrome (MLH1, PMS2, MSH2, MSH6)]]

- [[GTS5:Muir-Torre syndrome (MLH1, PMS2, MSH2, MSH6)]]

- [[GTS5:Constitutional mismatch repair deficiency (CMMRD) syndrome (MLH1, PMS2, MSH2, MSH6)]]

'''Homologous recombination'''

- [[GTS5:BRCA-related cancer predisposition syndrome (BRCA1, BRCA2)]]

- [[GTS5:PALB2-related cancer predisposition syndrome (PALB2)]]

- [[GTS5:RAD51-related cancer predisposition syndrome (RAD51C, RAD51D)]]

- [[GTS5:Fanconi anaemia (FANC genes)]]

'''Base excision repair genes'''

- [[GTS5:MUTYH-associated polyposis (MUTYH)]]

- [[GTS5:NTHL1-related tumour syndrome (NTHL1)]]

- [[GTS5:MBD4-associated neoplasia syndrome (MBD4)]]

'''Deficient nucleotide excision repair (NER) of DNA damage'''

- [[GTS5:Xeroderma Pigmentosum]]

'''Non-homologous end joining (NHEJ)'''

- [[GTS5:Ataxia-telangiectasia syndrome (ATM)]]

- [[GTS5:CHEK2-related hereditary (breast) cancer predisposition syndrome (CHEK2)]]

- [[GTS5:Nijmegen breakage syndrome (NBN)]]

'''DNA Polymerization'''

- [[GTS5:Polymerase proofreading-associated polyposis (POLD1, POLE)]]

'''Helicases'''

- [[GTS5:Bloom syndrome (BLM)]]

- [[GTS5:Werner syndrome (WRN)]]

- [[GTS5:Rothmund-Thomson syndrome (ANAPC1, RECQL4)]]

- [[GTS5:DDX41-related haematologic tumour predisposition syndrome (DDX41)]]

'''Chromosomal non-dysjunction (aneuploidy) syndromes'''

- [[GTS5:Mosaic variegated aneuploidy (BUB1B, CEP57, TRIP13, BUB1, BUB3)]]

- [[GTS5:Klinefelter syndrome]]

- [[GTS5:Turner syndrome]]

- [[GTS5:Down syndrome]]

==Telomere maintenance ([[GTS5:Telomere maintenance|Overview Page Link]])==
'''Telomere biology disorders'''

- [[GTS5:Dyskeratosis congenita (DKC1, TERT, TERC, TINF2, Other IBMFS genes)]]

- [[GTS5:POT1 and Shelterin-related tumour predisposition syndrome (POT1, ACD, TERF2IP, TERT promoter)]]

==Epigenetic drivers and chromatin remodelling ([[GTS5:pigenetic drivers and chromatin remodelling|Overview Page Link]])==
'''Imprinting disorders'''

- [[GTS5:Beckwith-Wiedemann spectrum (IGF2; CDKN1C)]]

'''Histone and DNA methylation'''

- [[GTS5:Enchondromatosis (IDH1, IDH2)]]

'''Chromatin remodelling pathway'''

- [[GTS5:Rhabdoid tumour predisposition syndrome (SMARCB1, SMARCA4)]]

- [[GTS5:Schwannomatosis (SMARCB1, LZTR1)]]

- [[GTS5:Clear cell meningioma predisposition syndrome (SMARCE1)]]

- [[GTS5:Weaver syndrome (EZH2)]]

==RNA regulation ([[GTS5:RNA regulation|Overview Page Link]])==
'''MicroRNA'''

- [[GTS5:DICER1-related tumour predisposition syndrome (DICER1)]]

- [[GTS5:MicroRNA processor tumour predisposition syndromes (DROSHA, DGCR8)]]

'''RNA splicing'''

- [[GTS5:Goldenhar syndrome (MYT1, SF3B2)]]

==Protein regulation ([[GTS5:Protein regulation|Overview Page Link]])==
'''Ubiquitin pathway'''

- [[GTS5:BAP1-related tumour predisposition syndrome (BAP1)]]