Gene:MYH11 - Revision history

Richard.Glen: Richard.Glen moved page MYH11 to Gene:MYH11 without leaving a redirect: Moved to Gene namespace

2026-01-28T18:35:45Z

Richard.Glen moved page MYH11 to Gene:MYH11 without leaving a redirect: Moved to Gene namespace

← Older revision		Revision as of 13:35, 28 January 2026
(No difference)

Bailey.Glen at 19:36, 12 December 2023

2023-12-12T19:36:05Z

← Older revision		Revision as of 14:36, 12 December 2023
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	==Cancer Category/Type==		==Cancer Category/Type==

	'''[http://www.ccga.io/index.php/Acute_Myeloid_Leukemia_(AML)_and_Related_Precursor_Neoplasms Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms]'''		'''[http://www.ccga.io/index.php/HAEM4:Acute_Myeloid_Leukemia_(AML)_and_Related_Precursor_Neoplasms Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms]'''

	'''[http://www.ccga.io/index.php/~~Acute_Myeloid_Leukemia_(AML)_with_inv(16)(p13.1q22)_or_t(16;16)(p13.1;q22);_CBFB-MYH11~~ Acute Myeloid Leukemia (AML) with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11]'''		'''[http://www.ccga.io/index.php/HAEM5:Acute_myeloid_leukaemia_with_CBFB::MYH11_fusion Acute Myeloid Leukemia (AML) with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11]'''

	Approximately 5-8% of AML cases have inv(16)(p13.1q22) or t(16;16)(p13.1;q22)<ref>Arber DA, et al., (2017). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. IARC Press: Lyon, France, p132-134.</ref><ref>Post SM, et al., (2015). Biology of adult myelocytic leukemia and myelodysplasia in The Molecular Basis of Cancer, 4th edition. Mendelsohn, J, Howley, PM, Israel, MA, Gray, JW, Thompson, CB. Editors. Elsevier Press: Philadelphia, USA, p395-406.</ref>. Either rearrangement leads to a CBFB-MYH11 fusion gene and may be an early event in the development of Acute Myeloid Leukemia (AML)<ref name=":0">{{Cite journal\|last=Ja\|first=Pulikkan\|last2=Lh\|first2=Castilla\|date=2018\|title=Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia\|url=https://pubmed.ncbi.nlm.nih.gov/29755956/\|language=en\|doi=10.3389/fonc.2018.00129\|pmc=PMC5932169\|pmid=29755956}}</ref>.		Approximately 5-8% of AML cases have inv(16)(p13.1q22) or t(16;16)(p13.1;q22)<ref>Arber DA, et al., (2017). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. IARC Press: Lyon, France, p132-134.</ref><ref>Post SM, et al., (2015). Biology of adult myelocytic leukemia and myelodysplasia in The Molecular Basis of Cancer, 4th edition. Mendelsohn, J, Howley, PM, Israel, MA, Gray, JW, Thompson, CB. Editors. Elsevier Press: Philadelphia, USA, p395-406.</ref>. Either rearrangement leads to a CBFB-MYH11 fusion gene and may be an early event in the development of Acute Myeloid Leukemia (AML)<ref name=":0">{{Cite journal\|last=Ja\|first=Pulikkan\|last2=Lh\|first2=Castilla\|date=2018\|title=Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia\|url=https://pubmed.ncbi.nlm.nih.gov/29755956/\|language=en\|doi=10.3389/fonc.2018.00129\|pmc=PMC5932169\|pmid=29755956}}</ref>.
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	==Internal Pages==		==Internal Pages==

	'''[http://www.ccga.io/index.php/Acute_Myeloid_Leukemia_(AML)_and_Related_Precursor_Neoplasms Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms]'''		'''[http://www.ccga.io/index.php/HAEM4:Acute_Myeloid_Leukemia_(AML)_and_Related_Precursor_Neoplasms Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms]'''

	'''[http://www.ccga.io/index.php/~~Acute_Myeloid_Leukemia_(AML)_with_inv(16)(p13.1q22)_or_t(16;16)(p13.1;q22);_CBFB-MYH11~~ Acute Myeloid Leukemia (AML) with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11]'''		'''[http://www.ccga.io/index.php/HAEM5:Acute_myeloid_leukaemia_with_CBFB::MYH11_fusion Acute Myeloid Leukemia (AML) with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11]'''

	'''[http://www.ccga.io/index.php/CBFB CBFB]'''		'''[http://www.ccga.io/index.php/CBFB CBFB]'''

Jennelleh at 16:57, 25 August 2020

2020-08-25T16:57:04Z

← Older revision		Revision as of 11:57, 25 August 2020
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	'''[http://www.ccga.io/index.php/Acute_Myeloid_Leukemia_(AML)_with_inv(16)(p13.1q22)_or_t(16;16)(p13.1;q22);_CBFB-MYH11 Acute Myeloid Leukemia (AML) with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11]'''		'''[http://www.ccga.io/index.php/Acute_Myeloid_Leukemia_(AML)_with_inv(16)(p13.1q22)_or_t(16;16)(p13.1;q22);_CBFB-MYH11 Acute Myeloid Leukemia (AML) with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11]'''

	Approximately 5-8% of AML cases have inv(16)(p13.1q22) or t(16;16)(p13.1;q22) [1,3]. Either rearrangement leads to a CBFB-MYH11 fusion gene and may be an early event in the development of Acute Myeloid Leukemia (AML) ~~[2]~~.		Approximately 5-8% of AML cases have inv(16)(p13.1q22) or t(16;16)(p13.1;q22)<ref>Arber DA, et al., (2017). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. IARC Press: Lyon, France, p132-134.</ref><ref>Post SM, et al., (2015). Biology of adult myelocytic leukemia and myelodysplasia in The Molecular Basis of Cancer, 4th edition. Mendelsohn, J, Howley, PM, Israel, MA, Gray, JW, Thompson, CB. Editors. Elsevier Press: Philadelphia, USA, p395-406.</ref>. Either rearrangement leads to a CBFB-MYH11 fusion gene and may be an early event in the development of Acute Myeloid Leukemia (AML)<ref name=":0">{{Cite journal\|last=Ja\|first=Pulikkan\|last2=Lh\|first2=Castilla\|date=2018\|title=Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia\|url=https://pubmed.ncbi.nlm.nih.gov/29755956/\|language=en\|doi=10.3389/fonc.2018.00129\|pmc=PMC5932169\|pmid=29755956}}</ref>.

	==Gene Overview==		==Gene Overview==

	The ''MYH11'' gene encodes a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a protein bearing the first 165 residues from the N terminus of core-binding factor beta (''CBFB'') and the C-terminal portion of the smooth muscle myosin heavy chain (''MYH11'') ~~[2]~~. The CBFβ–MYH11 fusion protein exerts a dominant negative function by increased binding to the transcription factor encoded by ''RUNX1'', thereby competing for free Runx1 protein and leading to lowered and altered transcription of myeloid genes ~~[2]~~.		The ''MYH11'' gene encodes a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a protein bearing the first 165 residues from the N terminus of core-binding factor beta (''CBFB'') and the C-terminal portion of the smooth muscle myosin heavy chain (''MYH11'')<ref name=":0" />. The CBFβ–MYH11 fusion protein exerts a dominant negative function by increased binding to the transcription factor encoded by ''RUNX1'', thereby competing for free Runx1 protein and leading to lowered and altered transcription of myeloid genes<ref name=":0" />.

	==Common Alteration Types==		==Common Alteration Types==
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	inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11		inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11

	The CBFβ–MYH11 fusion gene encodes a protein that exerts a dominant negative function by binding to the transcription factor encoded by ''RUNX1''. The fusion protein encoded by CBFβ–MYH11 competes (10-fold increased binding affinity) with normal CBFbeta protein for free Runx1 protein, leading to lowered and altered transcription of myeloid genes normally controlled by the CBFbeta and Runx1 transcription factors ~~[2]~~.		The CBFβ–MYH11 fusion gene encodes a protein that exerts a dominant negative function by binding to the transcription factor encoded by ''RUNX1''. The fusion protein encoded by CBFβ–MYH11 competes (10-fold increased binding affinity) with normal CBFbeta protein for free Runx1 protein, leading to lowered and altered transcription of myeloid genes normally controlled by the CBFbeta and Runx1 transcription factors<ref name=":0" />.

	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	\|-		\|-
	! Copy Number Loss !! Copy Number Gain !! LOH !! Loss-of-Function Mutation !! Gain-of-Function Mutation !! Translocation/Fusion		!Copy Number Loss!!Copy Number Gain!!LOH!!Loss-of-Function Mutation!!Gain-of-Function Mutation!!Translocation/Fusion
	\|-		\|-
	\| \|\| \|\| \|\| \|\| X \|\| X		\| \|\| \|\| \|\| \|\|X\|\|X
	\|}		\|}

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	'''[http://www.omim.org/entry/160745 ''MYH11'' by OMIM]''' - compendium of human genes and genetic phenotypes		'''[http://www.omim.org/entry/160745 ''MYH11'' by OMIM]''' - compendium of human genes and genetic phenotypes

	'''[https://databases.lovd.nl/shared/genes/MYH11 ''MYH11'' by LOVD(3)]''' - Leiden Open Variation Database		'''[https://databases.lovd.nl/shared/genes/MYH11 ''MYH11'' by LOVD(3)]''' - Leiden Open Variation Database

	'''[http://www.unav.es/genetica/TICdb/results.php?hgnc=MYH11 ''MYH11'' by TICdb]''' - database of Translocation breakpoints In Cancer		'''[http://www.unav.es/genetica/TICdb/results.php?hgnc=MYH11 ''MYH11'' by TICdb]''' - database of Translocation breakpoints In Cancer

	==References==		==References==
			<references />

			==Notes==
	1. Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.

	~~2. Pulikkan J.A. and Castilla L.H. (2018). Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia. Front Oncol. 8: 129. PMID 29755956 DOI: 10.3389/fonc.2018.00129~~

	3. Post SM, et al., (2015). Biology of adult myelocytic leukemia and myelodysplasia in The Molecular Basis of Cancer, 4th edition. Mendelsohn, J, Howley, PM, Israel, MA, Gray, JW, Thompson, CB. Editors. Elsevier Press: Philadelphia, USA, p395-406.

	== Notes ==
	<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.		<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.

	[[Category:Cancer Genes M]]		[[Category:Cancer Genes M]]

Jennelleh at 17:11, 6 August 2018

2018-08-06T17:11:01Z

← Older revision		Revision as of 12:11, 6 August 2018
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	==External Links==		==External Links==

	~~EXAMPLES~~

	'''[http://atlasgeneticsoncology.org//Genes/MYH11ID43.html ''MYH11'' by Atlas of Genetics and Cytogenetics in Oncology and Haematology]''' - detailed gene information		'''[http://atlasgeneticsoncology.org//Genes/MYH11ID43.html ''MYH11'' by Atlas of Genetics and Cytogenetics in Oncology and Haematology]''' - detailed gene information

Brian.Davis: /* External Links */

2018-08-02T15:47:06Z

External Links

← Older revision		Revision as of 10:47, 2 August 2018
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	'''[https://www.ncbi.nlm.nih.gov/gene/4629 MYH11 by NCBI Gene]''' - general gene information and summaries		'''[https://www.ncbi.nlm.nih.gov/gene/4629 MYH11 by NCBI Gene]''' - general gene information and summaries

			'''[http://www.omim.org/entry/160745 ''MYH11'' by OMIM]''' - compendium of human genes and genetic phenotypes

	'''[https://databases.lovd.nl/shared/genes/MYH11 ''MYH11'' by LOVD(3)]''' - Leiden Open Variation Database		'''[https://databases.lovd.nl/shared/genes/MYH11 ''MYH11'' by LOVD(3)]''' - Leiden Open Variation Database

Brian.Davis: /* External Links */

2018-08-02T15:23:06Z

External Links

← Older revision		Revision as of 10:23, 2 August 2018
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	'''[https://www.ncbi.nlm.nih.gov/gene/4629 MYH11 by NCBI Gene]''' - general gene information and summaries		'''[https://www.ncbi.nlm.nih.gov/gene/4629 MYH11 by NCBI Gene]''' - general gene information and summaries

			'''[https://databases.lovd.nl/shared/genes/MYH11 ''MYH11'' by LOVD(3)]''' - Leiden Open Variation Database

			'''[http://www.unav.es/genetica/TICdb/results.php?hgnc=MYH11 ''MYH11'' by TICdb]''' - database of Translocation breakpoints In Cancer

	==References==		==References==

Jennelleh at 23:10, 29 July 2018

2018-07-29T23:10:27Z

← Older revision		Revision as of 18:10, 29 July 2018
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	== Notes ==		== Notes ==
	<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.		<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.

			[[Category:Cancer Genes M]]

Jennelleh: /* Common Alteration Types */

2018-07-28T17:40:33Z

Common Alteration Types

← Older revision		Revision as of 12:40, 28 July 2018
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	inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11		inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11

	The CBFβ–MYH11 fusion gene encodes a protein that exerts a dominant negative function by binding to the transcription factor encoded by RUNX1. The fusion protein encoded by CBFβ–MYH11 competes (10-fold increased binding affinity) with normal CBFbeta protein for free Runx1 protein, ~~and~~ leading to lowered and altered transcription of myeloid genes normally controlled by CBFbeta and Runx1 transcription factors [2].		The CBFβ–MYH11 fusion gene encodes a protein that exerts a dominant negative function by binding to the transcription factor encoded by ''RUNX1''. The fusion protein encoded by CBFβ–MYH11 competes (10-fold increased binding affinity) with normal CBFbeta protein for free Runx1 protein, leading to lowered and altered transcription of myeloid genes normally controlled by the CBFbeta and Runx1 transcription factors [2].

	{\| class="wikitable sortable"		{\| class="wikitable sortable"
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	! Copy Number Loss !! Copy Number Gain !! LOH !! Loss-of-Function Mutation !! Gain-of-Function Mutation !! Translocation/Fusion		! Copy Number Loss !! Copy Number Gain !! LOH !! Loss-of-Function Mutation !! Gain-of-Function Mutation !! Translocation/Fusion
	\|-		\|-
	\| \|\| \|\| \|\| \|\| \|\| X		\| \|\| \|\| \|\| \|\| X \|\| X
	\|}		\|}

Jennelleh: /* Gene Overview */

2018-07-28T17:37:11Z

Gene Overview

← Older revision		Revision as of 12:37, 28 July 2018
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	==Gene Overview==		==Gene Overview==

	The MYH11 gene encodes a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a protein bearing the first 165 residues from the N terminus of core-binding factor beta (CBFB) and the C-terminal portion of the smooth muscle myosin heavy chain (MYH11) [2]. The CBFβ–MYH11 fusion protein exerts a dominant negative function by increased binding to the transcription factor encoded by RUNX1, thereby competing for free Runx1 protein, and leading to lowered and altered transcription of myeloid genes [2].		The ''MYH11'' gene encodes a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a protein bearing the first 165 residues from the N terminus of core-binding factor beta (''CBFB'') and the C-terminal portion of the smooth muscle myosin heavy chain (''MYH11'') [2]. The CBFβ–MYH11 fusion protein exerts a dominant negative function by increased binding to the transcription factor encoded by ''RUNX1'', thereby competing for free Runx1 protein and leading to lowered and altered transcription of myeloid genes [2].

	==Common Alteration Types==		==Common Alteration Types==

Jennelleh: /* Cancer Category/Type */

2018-07-28T17:36:00Z

Cancer Category/Type

← Older revision		Revision as of 12:36, 28 July 2018
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	'''[http://www.ccga.io/index.php/Acute_Myeloid_Leukemia_(AML)_with_inv(16)(p13.1q22)_or_t(16;16)(p13.1;q22);_CBFB-MYH11 Acute Myeloid Leukemia (AML) with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11]'''		'''[http://www.ccga.io/index.php/Acute_Myeloid_Leukemia_(AML)_with_inv(16)(p13.1q22)_or_t(16;16)(p13.1;q22);_CBFB-MYH11 Acute Myeloid Leukemia (AML) with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11]'''

	* Approximately 5-8% of AML cases have inv(16)(p13.1q22) or t(16;16)(p13.1;q22) [1,3]. Either rearrangement leads to a CBFB-MYH11 fusion gene and may be an early event in the development of Acute Myeloid Leukemia (AML) [2].		Approximately 5-8% of AML cases have inv(16)(p13.1q22) or t(16;16)(p13.1;q22) [1,3]. Either rearrangement leads to a CBFB-MYH11 fusion gene and may be an early event in the development of Acute Myeloid Leukemia (AML) [2].

	==Gene Overview==		==Gene Overview==