Bailey.Glen at 21:33, 4 December 2023

2023-12-04T21:33:27Z

← Older revision		Revision as of 16:33, 4 December 2023
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	==Definition / Description of Disease==		==Definition / Description of Disease==

	Waldenström macroglobulinemia (WM) is a clinicopathological entity characterized by presence of [[Lymphoplasmacytic ~~Lymphoma~~\|Lymphoplasmacytic lymphoma]] (LPL) associated with any level of monoclonal immunoglobulin M (IgM) in the serum.		Waldenström macroglobulinemia (WM) is a clinicopathological entity characterized by presence of [[HAEM5:Lymphoplasmacytic lymphoma\|Lymphoplasmacytic lymphoma]] (LPL) associated with any level of monoclonal immunoglobulin M (IgM) in the serum.

	==Synonyms / Terminology==		==Synonyms / Terminology==
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	==Sites of Involvement==		==Sites of Involvement==

	*By definition, diagnosis of Waldenström macroglobulinemia requires bone marrow involvement by [[Lymphoplasmacytic ~~Lymphoma~~\|Lymphoplasmacytic lymphoma]].		*By definition, diagnosis of Waldenström macroglobulinemia requires bone marrow involvement by [[HAEM5:Lymphoplasmacytic lymphoma\|Lymphoplasmacytic lymphoma]].
	*Lymphadenopathy and hepatosplenomegaly are more common at the time of relapse (up to 50%) rather than at the time of initial presentation (20%). <ref>{{Cite journal\|last=Shaheen\|first=Saad P.\|last2=Talwalkar\|first2=Sameer S.\|last3=Lin\|first3=Pei\|last4=Medeiros\|first4=L. Jeffrey\|date=2012-01\|title=Waldenström macroglobulinemia: a review of the entity and its differential diagnosis\|url=https://pubmed.ncbi.nlm.nih.gov/22156831\|journal=Advances in Anatomic Pathology\|volume=19\|issue=1\|pages=11–27\|doi=10.1097/PAP.0b013e31824019d0\|issn=1533-4031\|pmid=22156831}}</ref>		*Lymphadenopathy and hepatosplenomegaly are more common at the time of relapse (up to 50%) rather than at the time of initial presentation (20%). <ref>{{Cite journal\|last=Shaheen\|first=Saad P.\|last2=Talwalkar\|first2=Sameer S.\|last3=Lin\|first3=Pei\|last4=Medeiros\|first4=L. Jeffrey\|date=2012-01\|title=Waldenström macroglobulinemia: a review of the entity and its differential diagnosis\|url=https://pubmed.ncbi.nlm.nih.gov/22156831\|journal=Advances in Anatomic Pathology\|volume=19\|issue=1\|pages=11–27\|doi=10.1097/PAP.0b013e31824019d0\|issn=1533-4031\|pmid=22156831}}</ref>
	*Peripheral blood may have lymphocytosis with small circulating neoplastic cells with condensed chromatin and inconspicuous nucleoli. Rouleaux formation is also observed. <ref name=":5" />		*Peripheral blood may have lymphocytosis with small circulating neoplastic cells with condensed chromatin and inconspicuous nucleoli. Rouleaux formation is also observed. <ref name=":5" />
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	==Morphologic Features==		==Morphologic Features==

	*Bone marrow involvement by [[Lymphoplasmacytic ~~Lymphoma~~\|lymphoplasmacytic lymphoma]] is characterized by an interstitial, diffuse, or nodular patterns of infiltration. <ref name=":1" />		*Bone marrow involvement by [[HAEM5:Lymphoplasmacytic lymphoma\|lymphoplasmacytic lymphoma]] is characterized by an interstitial, diffuse, or nodular patterns of infiltration. <ref name=":1" />
	*Tumor burden of the bone marrow is variable with a wide range of percentage of involvement (5-95%). <ref name=":6" />		*Tumor burden of the bone marrow is variable with a wide range of percentage of involvement (5-95%). <ref name=":6" />
	*Paratrabecular infiltration is composed of nodular aggregates or single cells along the bone trabeculae with peritrabecular fibrosis and is seen in 95% of cases. <ref name=":4">{{Cite journal\|last=Bassarova\|first=Assia\|last2=Trøen\|first2=Gunhild\|last3=Spetalen\|first3=Signe\|last4=Micci\|first4=Francesca\|last5=Tierens\|first5=Anne\|last6=Delabie\|first6=Jan\|date=2015-06\|title=Lymphoplasmacytic lymphoma and marginal zone lymphoma in the bone marrow: paratrabecular involvement as an important distinguishing feature\|url=https://pubmed.ncbi.nlm.nih.gov/25972321\|journal=American Journal of Clinical Pathology\|volume=143\|issue=6\|pages=797–806\|doi=10.1309/AJCP6ZODWV1CIDME\|issn=1943-7722\|pmid=25972321}}</ref>		*Paratrabecular infiltration is composed of nodular aggregates or single cells along the bone trabeculae with peritrabecular fibrosis and is seen in 95% of cases. <ref name=":4">{{Cite journal\|last=Bassarova\|first=Assia\|last2=Trøen\|first2=Gunhild\|last3=Spetalen\|first3=Signe\|last4=Micci\|first4=Francesca\|last5=Tierens\|first5=Anne\|last6=Delabie\|first6=Jan\|date=2015-06\|title=Lymphoplasmacytic lymphoma and marginal zone lymphoma in the bone marrow: paratrabecular involvement as an important distinguishing feature\|url=https://pubmed.ncbi.nlm.nih.gov/25972321\|journal=American Journal of Clinical Pathology\|volume=143\|issue=6\|pages=797–806\|doi=10.1309/AJCP6ZODWV1CIDME\|issn=1943-7722\|pmid=25972321}}</ref>

Bailey.Glen at 18:51, 3 November 2023

2023-11-03T18:51:02Z

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 ==Notes==
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Bailey.Glen: Created page with "
==Primary Author(s)== Kapitolina Semenova, MD, Jack Reid, MD , Fabiola Quintero-Rivera, MD Departments of Pathology, Laboratory Medicine, and *Pediatrics, Division..."

2023-11-03T18:12:24Z

Created page with "<br /> ==Primary Author(s)*== Kapitolina Semenova, MD, Jack Reid, MD , Fabiola Quintero-Rivera, MD* Departments of Pathology, Laboratory Medicine, and *Pediatrics, Division..."

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HAEM4:Waldenstrom Macroglobulinemia - Revision history

Bailey.Glen at 21:33, 4 December 2023

Bailey.Glen at 18:51, 3 November 2023

Bailey.Glen: Created page with " ==Primary Author(s)*== Kapitolina Semenova, MD, Jack Reid, MD , Fabiola Quintero-Rivera, MD* Departments of Pathology, Laboratory Medicine, and *Pediatrics, Division..."

Bailey.Glen: Created page with "
==Primary Author(s)== Kapitolina Semenova, MD, Jack Reid, MD , Fabiola Quintero-Rivera, MD Departments of Pathology, Laboratory Medicine, and *Pediatrics, Division..."