HAEM5:Acute monocytic leukaemia - Revision history

Bailey.Glen at 17:06, 3 July 2025

2025-07-03T17:06:09Z

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	\|}		\|}

	~~==WHO Essential and Desirable Genetic Diagnostic Criteria==~~
	<span style="color:#0070C0">(''Instructions: The table will have the diagnostic criteria from the WHO book <u>autocompleted</u>; remove any <u>non</u>-genetics related criteria. If applicable, add text about other classification'' ''systems that define this entity and specify how the genetics-related criteria differ.'')</span>
	~~{\| class="wikitable"~~
	\|+
	\|WHO Essential Criteria (Genetics)*
	\|
	\|-
	\|WHO Desirable Criteria (Genetics)*
	\|
	\|-
	~~\|Other Classification~~
	\|
	\|}
	<nowiki>*</nowiki>Note: These are only the genetic/genomic criteria. Additional diagnostic criteria can be found in the [https://tumourclassification.iarc.who.int/home <u>WHO Classification of Tumours</u>].
	==Related Terminology==		==Related Terminology==

Bailey.Glen at 21:25, 25 May 2025

2025-05-25T21:25:32Z

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	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	\|-		\|-
	!Chr #!!~~'''~~Gain, Loss, Amp, LOH~~'''~~!!~~'''~~Minimal Region Cytoband and/or Genomic Coordinates [Genome Build; Size]~~'''~~!!~~'''~~Relevant Gene(s)~~'''~~		!Chr #!!Gain, Loss, Amp, LOH!!Minimal Region Cytoband and/or Genomic Coordinates [Genome Build; Size]!!Relevant Gene(s)
	!~~'''~~Diagnostic, Prognostic, and Therapeutic Significance - D, P, T~~'''~~		!Diagnostic, Prognostic, and Therapeutic Significance - D, P, T
	!~~'''~~Established Clinical Significance Per Guidelines - Yes or No (Source)~~'''~~		!Established Clinical Significance Per Guidelines - Yes or No (Source)
	!~~'''~~Clinical Relevance Details/Other Notes~~'''~~		!Clinical Relevance Details/Other Notes
	\|-		\|-
	\|<span class="blue-text">EXAMPLE:</span>		\|<span class="blue-text">EXAMPLE:</span>
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	!Chromosomal Pattern		!Chromosomal Pattern
	!Molecular Pathogenesis		!Molecular Pathogenesis
	!~~'''~~Prevalence -~~'''~~		!Prevalence -
	~~'''~~Common >20%, Recurrent 5-20% or Rare <5% (Disease)~~'''~~		Common >20%, Recurrent 5-20% or Rare <5% (Disease)
	!~~'''~~Diagnostic, Prognostic, and Therapeutic Significance - D, P, T~~'''~~		!Diagnostic, Prognostic, and Therapeutic Significance - D, P, T
	!~~'''~~Established Clinical Significance Per Guidelines - Yes or No (Source)~~'''~~		!Established Clinical Significance Per Guidelines - Yes or No (Source)
	!~~'''~~Clinical Relevance Details/Other Notes~~'''~~		!Clinical Relevance Details/Other Notes
	\|-		\|-
	\|<span class="blue-text">EXAMPLE:</span>		\|<span class="blue-text">EXAMPLE:</span>
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	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	\|-		\|-
	!Gene!!~~'''~~Genetic Alteration~~'''~~!!~~'''~~Tumor Suppressor Gene, Oncogene, Other~~'''~~!!~~'''~~Prevalence -~~'''~~		!Gene!!Genetic Alteration!!Tumor Suppressor Gene, Oncogene, Other!!Prevalence -
	~~'''~~Common >20%, Recurrent 5-20% or Rare <5% (Disease)~~'''~~		Common >20%, Recurrent 5-20% or Rare <5% (Disease)
	!~~'''~~Diagnostic, Prognostic, and Therapeutic Significance - D, P, T ~~'''~~		!Diagnostic, Prognostic, and Therapeutic Significance - D, P, T
	!~~'''~~Established Clinical Significance Per Guidelines - Yes or No (Source)~~'''~~		!Established Clinical Significance Per Guidelines - Yes or No (Source)
	!~~'''~~Clinical Relevance Details/Other Notes~~'''~~		!Clinical Relevance Details/Other Notes
	\|-		\|-
	\|<span class="blue-text">EXAMPLE:</span>''EGFR''		\|<span class="blue-text">EXAMPLE:</span>''EGFR''

Bailey.Glen at 20:01, 25 May 2025

2025-05-25T20:01:57Z

← Older revision		Revision as of 15:01, 25 May 2025
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	<nowiki>*</nowiki>Note: These are only the genetic/genomic criteria. Additional diagnostic criteria can be found in the [https://tumourclassification.iarc.who.int/home <u>WHO Classification of Tumours</u>].		<nowiki>*</nowiki>Note: These are only the genetic/genomic criteria. Additional diagnostic criteria can be found in the [https://tumourclassification.iarc.who.int/home <u>WHO Classification of Tumours</u>].
	==Related Terminology==		==Related Terminology==
	~~<span style="color:#0070C0">(''Instructions: The table will have the related terminology from the WHO <u>autocompleted</u>.)''</span>~~
	{\| class="wikitable"		{\| class="wikitable"
	\|+		\|+
	\|Acceptable		\|Acceptable
	\|		\|Acute monoblastic leukaemia
	\|-		\|-
	\|Not Recommended		\|Not Recommended
	\|		\|Acute myeloid leukaemia, M5; acute monoblastic leukaemia, M5a; acute monocytic leukaemia, M5b
	\|}		\|}

Bailey.Glen at 17:29, 24 March 2025

2025-03-24T17:29:35Z

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	{{DISPLAYTITLE:Acute monocytic leukaemia}}		{{DISPLAYTITLE:Acute monocytic leukaemia}}

	[[HAEM5:Table_of_Contents\|Haematolymphoid Tumours (WHO Classification, 5th ed.)]]		[[HAEM5:Table_of_Contents\|Haematolymphoid Tumours (WHO Classification, 5th ed.)]]

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	<br>		<br>
	Oregon Health & Science University, Portland, OR		Oregon Health & Science University, Portland, OR

	~~__TOC__~~

	==WHO Classification of Disease==		==WHO Classification of Disease==

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2025-02-11T13:59:17Z

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Bailey.Glen at 18:37, 10 February 2025

2025-02-10T18:37:06Z

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Bailey.Glen at 18:09, 10 February 2025

2025-02-10T18:09:03Z

← Older revision		Revision as of 13:09, 10 February 2025
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	<blockquote class='blockedit'>{{Box-round\|title=v4:Clinical Features\|The content below was from the old template. Please incorporate above.}}		<blockquote class='blockedit'>{{Box-round\|title=v4:Clinical Features\|The content below was from the old template. Please incorporate above.}}</blockquote>

	*Common manifestations include extramedullary masses, lymphadenopathy, cutaneous and gingival infiltration, CNS involvement and presenting with bleeding disorders<ref name=":0" />		*Common manifestations include extramedullary masses, lymphadenopathy, cutaneous and gingival infiltration, CNS involvement and presenting with bleeding disorders<ref name=":0" />
	*May present with acute respiratory failure<ref>{{Cite journal\|last=Azoulay\|first=Elie\|last2=Fieux\|first2=Fabienne\|last3=Moreau\|first3=Delphine\|last4=Thiery\|first4=Guillaume\|last5=Rousselot\|first5=Philippe\|last6=Parrot\|first6=Antoine\|last7=Le Gall\|first7=Jean-Roger\|last8=Dombret\|first8=Hervé\|last9=Schlemmer\|first9=Benoît\|date=2003\|title=Acute monocytic leukemia presenting as acute respiratory failure\|url=https://www.ncbi.nlm.nih.gov/pubmed/12574074\|journal=American Journal of Respiratory and Critical Care Medicine\|volume=167\|issue=10\|pages=1329–1333\|doi=10.1164/rccm.200206-554OC\|issn=1073-449X\|pmid=12574074}}</ref>		*May present with acute respiratory failure<ref>{{Cite journal\|last=Azoulay\|first=Elie\|last2=Fieux\|first2=Fabienne\|last3=Moreau\|first3=Delphine\|last4=Thiery\|first4=Guillaume\|last5=Rousselot\|first5=Philippe\|last6=Parrot\|first6=Antoine\|last7=Le Gall\|first7=Jean-Roger\|last8=Dombret\|first8=Hervé\|last9=Schlemmer\|first9=Benoît\|date=2003\|title=Acute monocytic leukemia presenting as acute respiratory failure\|url=https://www.ncbi.nlm.nih.gov/pubmed/12574074\|journal=American Journal of Respiratory and Critical Care Medicine\|volume=167\|issue=10\|pages=1329–1333\|doi=10.1164/rccm.200206-554OC\|issn=1073-449X\|pmid=12574074}}</ref>

			<blockquote class="blockedit">
			<center><span style="color:Maroon">'''End of V4 Section'''</span>
			----
	</blockquote>		</blockquote>
	==Sites of Involvement==		==Sites of Involvement==
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	<blockquote class='blockedit'>{{Box-round\|title=v4:Chromosomal Rearrangements (Gene Fusions)\|The content below was from the old template. Please incorporate above.}}		<blockquote class='blockedit'>{{Box-round\|title=v4:Chromosomal Rearrangements (Gene Fusions)\|The content below was from the old template. Please incorporate above.}}</blockquote>

	{\| class="wikitable sortable"		{\| class="wikitable sortable"
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	\|}		\|}

			<blockquote class="blockedit">
			<center><span style="color:Maroon">'''End of V4 Section'''</span>
			----
	</blockquote>		</blockquote>

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	* Individual Region Genomic Gain/Loss/LOH		* Individual Region Genomic Gain/Loss/LOH
	* Characteristic Chromosomal Patterns		* Characteristic Chromosomal Patterns
	* Gene Mutations (SNV/INDEL)}}		* Gene Mutations (SNV/INDEL)}}</blockquote>

	Diagnosis		Diagnosis
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	*Multiple studies have shown that t(8;16)(p11.2;p13.3) positive AML usually has a poor prognosis<ref>{{Cite journal\|last=Heim\|first=S.\|last2=Avanzi\|first2=G. C.\|last3=Billström\|first3=R.\|last4=Kristoffersson\|first4=U.\|last5=Mandahl\|first5=N.\|last6=Bekassy\|first6=A. N.\|last7=Garwicz\|first7=S.\|last8=Wiebe\|first8=T.\|last9=Pegoraro\|first9=L.\|date=1987\|title=A new specific chromosomal rearrangement, t(8;16) (p11;p13), in acute monocytic leukaemia\|url=https://www.ncbi.nlm.nih.gov/pubmed/3476150\|journal=British Journal of Haematology\|volume=66\|issue=3\|pages=323–326\|doi=10.1111/j.1365-2141.1987.tb06917.x\|issn=0007-1048\|pmid=3476150}}</ref><ref>{{Cite journal\|last=Haferlach\|first=T.\|last2=Kohlmann\|first2=A.\|last3=Klein\|first3=H.-U.\|last4=Ruckert\|first4=C.\|last5=Dugas\|first5=M.\|last6=Williams\|first6=P. M.\|last7=Kern\|first7=W.\|last8=Schnittger\|first8=S.\|last9=Bacher\|first9=U.\|date=2009\|title=AML with translocation t(8;16)(p11;p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features\|url=https://www.ncbi.nlm.nih.gov/pubmed/19194466\|journal=Leukemia\|volume=23\|issue=5\|pages=934–943\|doi=10.1038/leu.2008.388\|issn=1476-5551\|pmid=19194466}}</ref>.		*Multiple studies have shown that t(8;16)(p11.2;p13.3) positive AML usually has a poor prognosis<ref>{{Cite journal\|last=Heim\|first=S.\|last2=Avanzi\|first2=G. C.\|last3=Billström\|first3=R.\|last4=Kristoffersson\|first4=U.\|last5=Mandahl\|first5=N.\|last6=Bekassy\|first6=A. N.\|last7=Garwicz\|first7=S.\|last8=Wiebe\|first8=T.\|last9=Pegoraro\|first9=L.\|date=1987\|title=A new specific chromosomal rearrangement, t(8;16) (p11;p13), in acute monocytic leukaemia\|url=https://www.ncbi.nlm.nih.gov/pubmed/3476150\|journal=British Journal of Haematology\|volume=66\|issue=3\|pages=323–326\|doi=10.1111/j.1365-2141.1987.tb06917.x\|issn=0007-1048\|pmid=3476150}}</ref><ref>{{Cite journal\|last=Haferlach\|first=T.\|last2=Kohlmann\|first2=A.\|last3=Klein\|first3=H.-U.\|last4=Ruckert\|first4=C.\|last5=Dugas\|first5=M.\|last6=Williams\|first6=P. M.\|last7=Kern\|first7=W.\|last8=Schnittger\|first8=S.\|last9=Bacher\|first9=U.\|date=2009\|title=AML with translocation t(8;16)(p11;p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features\|url=https://www.ncbi.nlm.nih.gov/pubmed/19194466\|journal=Leukemia\|volume=23\|issue=5\|pages=934–943\|doi=10.1038/leu.2008.388\|issn=1476-5551\|pmid=19194466}}</ref>.

			<blockquote class="blockedit">
			<center><span style="color:Maroon">'''End of V4 Section'''</span>
			----
	</blockquote>		</blockquote>
	==Individual Region Genomic Gain / Loss / LOH==		==Individual Region Genomic Gain / Loss / LOH==
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	\|}		\|}

	<blockquote class='blockedit'>{{Box-round\|title=v4:Characteristic Chromosomal Aberrations / Patterns\|The content below was from the old template. Please incorporate above.}}		<blockquote class='blockedit'>{{Box-round\|title=v4:Characteristic Chromosomal Aberrations / Patterns\|The content below was from the old template. Please incorporate above.}}</blockquote>

	Myeloid-associated nonspecific cytogenetic abnormalities are present in most cases.		Myeloid-associated nonspecific cytogenetic abnormalities are present in most cases.

			<blockquote class="blockedit">
			<center><span style="color:Maroon">'''End of V4 Section'''</span>
			----
	</blockquote>		</blockquote>
	==Gene Mutations (SNV / INDEL)==		==Gene Mutations (SNV / INDEL)==

Bailey.Glen at 22:20, 6 September 2024

2024-09-06T22:20:27Z

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	__TOC__		__TOC__

	==~~Cancer Category / Type~~==		==WHO Classification of Disease==

	~~[[AML~~\|Acute ~~Myeloid Leukemia]]~~		{\| class="wikitable"
			!Structure
	~~==Cancer Sub~~-~~Classification /~~ Subtype==		!Disease
			\|-
	Acute ~~monoblastic and~~ monocytic ~~leukemia~~		\|Book
			\|Haematolymphoid Tumours (5th ed.)
			\|-
			\|Category
			\|Myeloid proliferations and neoplasms
			\|-
			\|Family
			\|Acute myeloid leukaemia
			\|-
			\|Type
			\|Acute myeloid leukaemia, defined by differentiation
			\|-
			\|Subtype(s)
			\|Acute monocytic leukaemia
			\|}

	==Definition / Description of Disease==		==Definition / Description of Disease==

Bailey.Glen at 21:47, 6 September 2024

2024-09-06T21:47:39Z

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Bailey.Glen: Undo revision 14804 by Bailey.Glen (talk)

2024-09-06T19:51:58Z

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