Compendium of Cancer Genome Aberrations

Breast Cancer: Recurrent Genomic Alterations: Difference between revisions

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'''Table 2 - Major clinically significant genes associated with somatic sequence alterations in breast cancer.''' Table derived from Geiersbach et al., 2018 [<nowiki>[https://pubmed.ncbi.nlm.nih.gov/32087595/ |#mwt5|mw:ExpandedAttrs|{"attribs":[[{"txt":"href"},{"html":"https://pubmed.ncbi.nlm.nih.gov/32087595/ <span typeof=\"mw:Nowiki\" data-parsoid='{\"dsr\":[2320,2350,8,9]}'>PMID 32087595</span>"}]</nowiki>]}]] with permission from Cancer Genetics.
'''Table 2 - Major clinically significant genes associated with somatic sequence alterations in breast cancer.''' Table derived from Geiersbach et al., 2018 [[https://pubmed.ncbi.nlm.nih.gov/32087595/ PMID 32087595]] with permission from Cancer Genetics.
{| class="wikitable"
{| class="wikitable"
|'''Gene(s)'''
|'''Gene(s)'''
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|PARP inhibitors (germline)
|PARP inhibitors (germline)
|-
|-
|''[[BRCA1 syndrome|BRCA1]], [[BRCA2 syndrome|BRCA2]]''
|''[[BRCA1]], [[BRCA2]]''
|1
|1
|Often hereditary risk; TNBC
|Often hereditary risk; TNBC
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'''Table 3 - Genes with known hereditary risk associations in breast cancer.''' Table derived from Geiersbach et al., 2018 [<nowiki>[https://pubmed.ncbi.nlm.nih.gov/32087595/ |#mwt11|mw:ExpandedAttrs|{"attribs":[[{"txt":"href"},{"html":"https://pubmed.ncbi.nlm.nih.gov/32087595/ <span typeof=\"mw:Nowiki\" data-parsoid='{\"dsr\":[5592,5622,8,9]}'>PMID 32087595</span>"}]</nowiki>]}]] with permission from Cancer Genetics.
'''Table 3 - Genes with known hereditary risk associations in breast cancer.''' Table derived from Geiersbach et al., 2018 [[https://pubmed.ncbi.nlm.nih.gov/32087595/ PMID 32087595]] with permission from Cancer Genetics.
{| class="wikitable"
{| class="wikitable"
|'''Gene'''
|'''Gene'''
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|TNBC
|TNBC
|-
|-
|''BRCA1''
|''[[BRCA1]]''
|[[BRCA1 syndrome|BRCA-Related Breast/ Ovarian Cancer Syndrome]]; TNBC
|[[BRCA1 syndrome|BRCA-Related Breast/ Ovarian Cancer Syndrome]]; TNBC
|-
|-
|''BRCA2''
|''[[BRCA2]]''
|[[BRCA2 syndrome|BRCA-Related Breast/ Ovarian Cancer Syndrome]]; TNBC
|[[BRCA2 syndrome|BRCA-Related Breast/ Ovarian Cancer Syndrome]]; TNBC
|-
|-
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