Compendium of Cancer Genome Aberrations

HAEM4:Splenic Diffuse Red Pulp Small B-cell Lymphoma: Difference between revisions

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{{DISPLAYTITLE:Splenic Diffuse Red Pulp Small B-cell Lymphoma}}
<blockquote class='blockedit'>{{Box-round|title=PREVIOUS EDITION|This page from the 4th edition of Haematolymphoid Tumours is being updated. See 5th edition [[HAEM5:Table_of_Contents|Table of Contents]].
}}</blockquote>
==Primary Author(s)*==
==Primary Author(s)*==


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==Cancer Category/Type==
==Cancer Category/Type==


*[[Mature B-Cell Neoplasms|Mature B-Cell Neoplasm]]
*[[HAEM4:Mature B-Cell Neoplasms|Mature B-Cell Neoplasm]]


==Cancer Sub-Classification / Subtype==
==Cancer Sub-Classification / Subtype==


*[[Splenic B-cell Lymphoma/Leukemia, Unclassifiable]]
*[[HAEM4:Splenic B-cell Lymphoma/Leukemia, Unclassifiable]]


==Definition / Description of Disease==
==Definition / Description of Disease==
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*SDRPL is a provisional WHO entity and definitive diagnostic criteria have not been determined
*SDRPL is a provisional WHO entity and definitive diagnostic criteria have not been determined
**Diagnosis of exclusion
**Diagnosis of exclusion
***Differential of splenic lymphomas with cytoplasmic projections:  [[Hairy Cell Leukemia|HCL]], [[Hairy Cell Leukemia Variant|HCL-v]], [[Splenic Marginal Zone Lymphoma|SMZL]]
***Differential of splenic lymphomas with cytoplasmic projections:  [[HAEM5:Hairy cell leukaemia|HCL]], [[HAEM5:Hairy cell leukaemia Variant|HCL-v]], [[HAEM5:Splenic marginal zone lymphoma|SMZL]]
**Distinction is by clinical history, morphology, and immunohistochemistry
**Distinction is by clinical history, morphology, and immunohistochemistry
***No pathognomonic diagnostic markers (molecular or otherwise)
***No pathognomonic diagnostic markers (molecular or otherwise)
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|BRAF p.Val600Glu
|BRAF p.Val600Glu
|Possible role in diagnosis (exclusion)
|Possible role in diagnosis (exclusion)
|Prevalent in [[Hairy Cell Leukemia|HCL]] but rare/absent in SDRPL<ref name=":3" />
|Prevalent in [[HAEM5:Hairy cell leukaemia|HCL]] but rare/absent in SDRPL<ref name=":3" />
|-
|-
|MAP2K1
|MAP2K1
|Possible role in diagnosis (exclusion)
|Possible role in diagnosis (exclusion)
|Prevalent in [[Hairy Cell Leukemia Variant|HCL-v]] and a subset of cases classified as [[Hairy Cell Leukemia|HCL]] but uncommon in SDRPL<ref name=":3" />
|Prevalent in [[HAEM5:Hairy cell leukaemia Variant|HCL-v]] and a subset of cases classified as [[HAEM5:Hairy cell leukaemia|HCL]] but uncommon in SDRPL<ref name=":3" />
|-
|-
|KLF2 and TNFAIP3
|KLF2 and TNFAIP3
|Possible role in diagnosis (exclusion)
|Possible role in diagnosis (exclusion)
|Prevalent in [[Splenic Marginal Zone Lymphoma|SMZL]] but rare/absent in SDRPL<ref name=":3" />
|Prevalent in [[HAEM5:Splenic marginal zone lymphoma|SMZL]] but rare/absent in SDRPL<ref name=":3" />
|-
|-
|MYD88
|MYD88
|Possible role in diagnosis (exclusion)
|Possible role in diagnosis (exclusion)
|Prevalent in [[Lymphoplasmacytic Lymphoma|LPL]] and [[Splenic Marginal Zone Lymphoma|SMZL]] but rare/absent in SDRPL<ref name=":3" />
|Prevalent in [[HAEM5:Lymphoplasmacytic lymphoma|LPL]] and [[HAEM5:Splenic marginal zone lymphoma|SMZL]] but rare/absent in SDRPL<ref name=":3" />
|-
|-
|BCOR
|BCOR
|Possible role in diagnosis (inclusion)
|Possible role in diagnosis (inclusion)
|Prevalent in SDRPL but rare/absent in [[Hairy Cell Leukemia|HCL]], [[Hairy Cell Leukemia Variant|HCL-v]], and [[Splenic Marginal Zone Lymphoma|SMZL]]<ref name=":3" />
|Prevalent in SDRPL but rare/absent in [[HAEM5:Hairy cell leukaemia|HCL]], [[HAEM5:Hairy cell leukaemia Variant|HCL-v]], and [[HAEM5:Splenic marginal zone lymphoma|SMZL]]<ref name=":3" />
|}
|}


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==Links==
==Links==


*[[Hairy Cell Leukemia]]
*[[HAEM5:Hairy cell leukaemia]]
*[[Hairy Cell Leukemia Variant]]
*[[HAEM5:Hairy cell leukaemia Variant]]
*[[Splenic B-cell Lymphoma/Leukemia, Unclassifiable]]
*[[HAEM4:Splenic B-cell Lymphoma/Leukemia, Unclassifiable]]
*[[Splenic Marginal Zone Lymphoma]]
*[[HAEM5:Splenic marginal zone lymphoma]]


==References==
==References==
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==Notes==
==Notes==
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage).  Additional global feedback or concerns are also welcome.
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage).  Additional global feedback or concerns are also welcome.
[[Category:HAEM4]] [[Category:DISEASE]]
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