HAEM5:Indolent T-cell lymphoma of the gastrointestinal tract: Difference between revisions

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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":1">{{Cite journal|last=E|first=Margolskee|last2=V|first2=Jobanputra|last3=Sk|first3=Lewis|last4=B|first4=Alobeid|last5=Ph|first5=Green|last6=G|first6=Bhagat|date=2013|title=Indolent small intestinal CD4+ T-cell lymphoma is a distinct entity with unique biologic and clinical features|url=https://pubmed.ncbi.nlm.nih.gov/23861889/|language=en|doi=10.1371/journal.pone.0068343|pmc=PMC3701677|pmid=23861889}}</ref></blockquote>
<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":1">{{Cite journal|last=E|first=Margolskee|last2=V|first2=Jobanputra|last3=Sk|first3=Lewis|last4=B|first4=Alobeid|last5=Ph|first5=Green|last6=G|first6=Bhagat|date=2013|title=Indolent small intestinal CD4+ T-cell lymphoma is a distinct entity with unique biologic and clinical features|url=https://pubmed.ncbi.nlm.nih.gov/23861889/|language=en|doi=10.1371/journal.pone.0068343|pmc=PMC3701677|pmid=23861889}}</ref><blockquote class="blockedit">
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==Synonyms / Terminology==
==Synonyms / Terminology==


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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":2">{{Cite journal|last=Am|first=Perry|last2=Ra|first2=Warnke|last3=Q|first3=Hu|last4=P|first4=Gaulard|last5=C|first5=Copie-Bergman|last6=S|first6=Alkan|last7=Hy|first7=Wang|last8=Jx|first8=Cheng|last9=Cm|first9=Bacon|date=2013|title=Indolent T-cell lymphoproliferative disease of the gastrointestinal tract|url=https://pubmed.ncbi.nlm.nih.gov/24009234/|language=en|doi=10.1182/blood-2013-07-512830|pmc=PMC3837508|pmid=24009234}}</ref></blockquote>
<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":2">{{Cite journal|last=Am|first=Perry|last2=Ra|first2=Warnke|last3=Q|first3=Hu|last4=P|first4=Gaulard|last5=C|first5=Copie-Bergman|last6=S|first6=Alkan|last7=Hy|first7=Wang|last8=Jx|first8=Cheng|last9=Cm|first9=Bacon|date=2013|title=Indolent T-cell lymphoproliferative disease of the gastrointestinal tract|url=https://pubmed.ncbi.nlm.nih.gov/24009234/|language=en|doi=10.1182/blood-2013-07-512830|pmc=PMC3837508|pmid=24009234}}</ref><blockquote class="blockedit">
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==Clinical Features==
==Clinical Features==


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*Abdominal pain
*Abdominal pain
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'''ADD REF'''
'''ADD REF'''


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==Sites of Involvement==
==Sites of Involvement==
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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":1" /><ref name=":3">{{Cite journal|last=M|first=Cheminant|last2=J|first2=Bruneau|last3=G|first3=Malamut|last4=D|first4=Sibon|last5=N|first5=Guegan|last6=T|first6=van Gils|last7=S|first7=Cording|last8=A|first8=Trinquand|last9=V|first9=Verkarre|date=2019|title=NKp46 is a diagnostic biomarker and may be a therapeutic target in gastrointestinal T-cell lymphoproliferative diseases: a CELAC study|url=https://pubmed.ncbi.nlm.nih.gov/30448772/|language=en|pmid=30448772}}</ref></blockquote>
<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":1" /><ref name=":3">{{Cite journal|last=M|first=Cheminant|last2=J|first2=Bruneau|last3=G|first3=Malamut|last4=D|first4=Sibon|last5=N|first5=Guegan|last6=T|first6=van Gils|last7=S|first7=Cording|last8=A|first8=Trinquand|last9=V|first9=Verkarre|date=2019|title=NKp46 is a diagnostic biomarker and may be a therapeutic target in gastrointestinal T-cell lymphoproliferative diseases: a CELAC study|url=https://pubmed.ncbi.nlm.nih.gov/30448772/|language=en|pmid=30448772}}</ref><blockquote class="blockedit">
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==Chromosomal Rearrangements (Gene Fusions)==
==Chromosomal Rearrangements (Gene Fusions)==


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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":0">{{Cite journal|last=A|first=Sharma|last2=N|first2=Oishi|last3=Rl|first3=Boddicker|last4=G|first4=Hu|last5=Hk|first5=Benson|last6=Rp|first6=Ketterling|last7=Pt|first7=Greipp|last8=Dl|first8=Knutson|last9=Sm|first9=Kloft-Nelson|date=2018|title=Recurrent STAT3-JAK2 fusions in indolent T-cell lymphoproliferative disorder of the gastrointestinal tract|url=https://pubmed.ncbi.nlm.nih.gov/29592893/|language=en|doi=10.1182/blood-2018-01-830968|pmc=PMC5958657|pmid=29592893}}</ref></blockquote>
<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":0">{{Cite journal|last=A|first=Sharma|last2=N|first2=Oishi|last3=Rl|first3=Boddicker|last4=G|first4=Hu|last5=Hk|first5=Benson|last6=Rp|first6=Ketterling|last7=Pt|first7=Greipp|last8=Dl|first8=Knutson|last9=Sm|first9=Kloft-Nelson|date=2018|title=Recurrent STAT3-JAK2 fusions in indolent T-cell lymphoproliferative disorder of the gastrointestinal tract|url=https://pubmed.ncbi.nlm.nih.gov/29592893/|language=en|doi=10.1182/blood-2018-01-830968|pmc=PMC5958657|pmid=29592893}}</ref><blockquote class="blockedit">
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* Individual Region Genomic Gain/Loss/LOH
* Individual Region Genomic Gain/Loss/LOH
* Characteristic Chromosomal Patterns
* Characteristic Chromosomal Patterns
* Gene Mutations (SNV/INDEL)}}
* Gene Mutations (SNV/INDEL)}}</blockquote>


*'''Diagnosis'''
*'''Diagnosis'''
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***The potential use of JAK-STAT inhibitors such as tofacinib and AZD1480 has not been formally tested
***The potential use of JAK-STAT inhibitors such as tofacinib and AZD1480 has not been formally tested


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==Individual Region Genomic Gain / Loss / LOH==
==Individual Region Genomic Gain / Loss / LOH==
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{| class="wikitable sortable"
{| class="wikitable sortable"
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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":1" /></blockquote>
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==Characteristic Chromosomal Patterns==
==Characteristic Chromosomal Patterns==
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*  
*  


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==Gene Mutations (SNV / INDEL)==
==Gene Mutations (SNV / INDEL)==
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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref>{{Cite journal|last=Cr|first=Soderquist|last2=N|first2=Patel|last3=Vv|first3=Murty|last4=S|first4=Betman|last5=N|first5=Aggarwal|last6=Kh|first6=Young|last7=L|first7=Xerri|last8=R|first8=Leeman-Neill|last9=Sk|first9=Lewis|date=2020|title=Genetic and phenotypic characterization of indolent T-cell lymphoproliferative disorders of the gastrointestinal tract|url=https://pubmed.ncbi.nlm.nih.gov/31558678/|language=en|doi=10.3324/haematol.2019.230961|pmc=PMC7327650|pmid=31558678}}</ref></blockquote>
<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref>{{Cite journal|last=Cr|first=Soderquist|last2=N|first2=Patel|last3=Vv|first3=Murty|last4=S|first4=Betman|last5=N|first5=Aggarwal|last6=Kh|first6=Young|last7=L|first7=Xerri|last8=R|first8=Leeman-Neill|last9=Sk|first9=Lewis|date=2020|title=Genetic and phenotypic characterization of indolent T-cell lymphoproliferative disorders of the gastrointestinal tract|url=https://pubmed.ncbi.nlm.nih.gov/31558678/|language=en|doi=10.3324/haematol.2019.230961|pmc=PMC7327650|pmid=31558678}}</ref><blockquote class="blockedit">
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==Epigenomic Alterations==
==Epigenomic Alterations==
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==Genetic Diagnostic Testing Methods==
==Genetic Diagnostic Testing Methods==