HAEM5:Kikuchi-Fujimoto disease: Difference between revisions

<big>Kikuchi-Fujimoto disease does '''not have characteristic or recurrent genetic alterations'''.</big>

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<big>Kikuchi-Fujimoto disease does '''not have characteristic or recurrent genetic alterations'''.</big>

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<big>Kikuchi-Fujimoto disease does '''not have characteristic or recurrent genetic alterations'''.</big>

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<big>Kikuchi-Fujimoto disease does '''not have characteristic or recurrent genetic alterations'''.</big>  

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<big>Kikuchi-Fujimoto disease does '''not have characteristic or recurrent genetic alterations'''.</big>  

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<big>Genetic testing is non-contributory to rule-in a diagnosis of Kikuchi-Fujimoto disease. T-cell receptor gene rearrangement and/or NGS studies may play a role when morphology and immunophenotype raise concern for lymphoma.</big>

<big>Most published studies indicate a '''reactive, immune-mediated process''' rather than a neoplastic one. Some reports describe '''HLA class II associations''' (e.g., HLA-DPA1 and HLA-DPB1 polymorphisms<ref name=":0">Tanaka T, Ohmori M, Yasunaga S, Ohshima K, Kikuchi M, Sasazuki T. DNA typing of HLA class II genes (HLA-DR, -DQ and -DP) in Japanese patients with histiocytic necrotizing lymphadenitis (Kikuchi's disease). ''Tissue Antigens''. 1999;54(3):246-253. doi:10.1034/j.1399-0039.1999.540305.x</ref>) in certain populations</big><ref name=":0" /><big>, suggesting a genetic susceptibility.</big>  

<big>NA</big>

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<nowiki>*</nowiki>''Citation of this Page'': “Kikuchi-Fujimoto disease”. Compendium of Cancer Genome Aberrations (CCGA), Cancer Genomics Consortium (CGC), updated {{REVISIONMONTH}}/{{REVISIONDAY}}/{{REVISIONYEAR}}, <nowiki>https://ccga.io/index.php/HAEM5:Kikuchi-Fujimoto_disease</nowiki>.