Compendium of Cancer Genome Aberrations

HAEM4:Acute Myeloid Leukemia (AML) with Mutated RUNX1: Difference between revisions

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Created page with "==Primary Author(s)*== Iris Martin, M.D. Daynna J. Wolff, Ph.D. __TOC__ ==Cancer Category/Type== Acute Myeloid Leukemia ==Cancer Sub-Classification / Subtype== Acute My..."
 
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{{DISPLAYTITLE:Acute Myeloid Leukemia (AML) with Mutated RUNX1}}
<blockquote class='blockedit'>{{Box-round|title=PREVIOUS EDITION|This page from the 4th edition of Haematolymphoid Tumours is being updated. See 5th edition [[HAEM5:Table_of_Contents|Table of Contents]].
}}</blockquote>
==Primary Author(s)*==
==Primary Author(s)*==


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==Chromosomal Rearrangements (Gene Fusions)==
==Chromosomal Rearrangements (Gene Fusions)==


The ''RUNX1'' gene is involved in the 8;21 translocation (see [http://www.ccga.io/index.php/Acute_Myeloid_Leukemia_(AML)_with_t(8;21)(q22;q22.1);_RUNX1-RUNX1T1 Acute Myeloid Leukemia (AML) with t(8;21)(q22;q22.1); RUNX1-RUNX1T1] page), but the AML with mutated ''RUNX1'' subcategory is specific for those cases with a somatic, acquired mutation in the ''RUNX1'' gene.
The ''RUNX1'' gene is involved in the 8;21 translocation (see [http://www.ccga.io/index.php/HAEM5:Acute_myeloid_leukaemia_with_RUNX1::RUNX1T1_fusion Acute Myeloid Leukemia (AML) with t(8;21)(q22;q22.1); RUNX1-RUNX1T1] page), but the AML with mutated ''RUNX1'' subcategory is specific for those cases with a somatic, acquired mutation in the ''RUNX1'' gene.


==Characteristic Chromosomal Aberrations / Patterns==
==Characteristic Chromosomal Aberrations / Patterns==
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==Notes==
==Notes==
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage).  Additional global feedback or concerns are also welcome.
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage).  Additional global feedback or concerns are also welcome.
 
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