HAEM4:Hairy Cell Leukemia: Difference between revisions - Compendium of Cancer Genome Aberrations

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==Cancer Category/Type==

*[[Mature B-Cell Neoplasms|Mature B-Cell Neoplasm]]

*[[HAEM4:Mature B-Cell Neoplasms|Mature B-Cell Neoplasm]]

==Cancer Sub-Classification / Subtype==

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<sup>‡</sup>Specific mutations in these genes can be found in [https://www.cbioportal.org/ cBioPortal] and [https://cancer.sanger.ac.uk/cosmic COSMIC].

'''*'''The WHO states that BRAF p.Val600Glu is detected in virtually all cases and notes that the classification of B-cell leukemias that are immunophenotypically and morphologically classified as HCL but lack BRAF activating mutations (but instead have MAP2K1 activating mutations and use the IGHV4-34 gene segment) is uncertain. These seem to be more similar molecularly and clinically to [[~~Hairy Cell Leukemia Variant~~|HCLv]].

'''*'''The WHO states that BRAF p.Val600Glu is detected in virtually all cases and notes that the classification of B-cell leukemias that are immunophenotypically and morphologically classified as HCL but lack BRAF activating mutations (but instead have MAP2K1 activating mutations and use the IGHV4-34 gene segment) is uncertain. These seem to be more similar molecularly and clinically to [[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli|HCLv]].

*BRAF and MAP2K1 activating mutations are mutually exclusive

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|BRAF p.Val600Glu

|Diagnostic

|May be useful when immunophenotype is equivocal; Excludes [[~~Hairy Cell Leukemia Variant~~|HCLv]]

|May be useful when immunophenotype is equivocal; Excludes [[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli|HCLv]]

|-

|MAP2K1

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==Links==

*[[~~Hairy Cell Leukemia Variant~~]]

*[[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli]]

*[[Splenic ~~Diffuse Red Pulp Small~~ B-cell ~~Lymphoma~~]]

*[[HAEM5:Splenic diffuse red pulp small B-cell lymphoma]]

==References==

@@ Line 11: / Line 11: @@
 ==Cancer Category/Type==
-*[[Mature B-Cell Neoplasms|Mature B-Cell Neoplasm]]
+*[[HAEM4:Mature B-Cell Neoplasms|Mature B-Cell Neoplasm]]
 ==Cancer Sub-Classification / Subtype==
@@ Line 174: / Line 174: @@
 <sup>‡</sup>Specific mutations in these genes can be found in [https://www.cbioportal.org/ cBioPortal] and [https://cancer.sanger.ac.uk/cosmic COSMIC].
-'''*'''The WHO states that BRAF p.Val600Glu is detected in virtually all cases and notes that the classification of B-cell leukemias that are immunophenotypically and morphologically classified as HCL but lack BRAF activating mutations (but instead have MAP2K1 activating mutations and use the IGHV4-34 gene segment) is uncertain.  These seem to be more similar molecularly and clinically to [[Hairy Cell Leukemia Variant|HCLv]].
+'''*'''The WHO states that BRAF p.Val600Glu is detected in virtually all cases and notes that the classification of B-cell leukemias that are immunophenotypically and morphologically classified as HCL but lack BRAF activating mutations (but instead have MAP2K1 activating mutations and use the IGHV4-34 gene segment) is uncertain.  These seem to be more similar molecularly and clinically to [[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli|HCLv]].
 *BRAF and MAP2K1 activating mutations are mutually exclusive
@@ Line 229: / Line 229: @@
 |BRAF p.Val600Glu
 |Diagnostic
-|May be useful when immunophenotype is equivocal; Excludes [[Hairy Cell Leukemia Variant|HCLv]]
+|May be useful when immunophenotype is equivocal; Excludes [[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli|HCLv]]
 |-
 |MAP2K1
@@ Line 257: / Line 257: @@
 ==Links==
-*[[Hairy Cell Leukemia Variant]]
+*[[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli]]
-*[[Splenic Diffuse Red Pulp Small B-cell Lymphoma]]
+*[[HAEM5:Splenic diffuse red pulp small B-cell lymphoma]]
 ==References==