HAEM4:Hairy Cell Leukemia Variant: Difference between revisions
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==Cancer Category/Type== | ==Cancer Category/Type== | ||
*[[Splenic B-cell Lymphoma/Leukemia, Unclassifiable]] | *[[HAEM4:Splenic B-cell Lymphoma/Leukemia, Unclassifiable]] | ||
==Cancer Sub-Classification / Subtype== | ==Cancer Sub-Classification / Subtype== | ||
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*HCLv is a rare chronic neoplasm of B-cell origin seen mostly in adults | *HCLv is a rare chronic neoplasm of B-cell origin seen mostly in adults | ||
*Name derives from clinicopathologic similarity to [[Hairy | *Name derives from clinicopathologic similarity to [[HAEM5:Hairy cell leukaemia|hairy cell leukemia]] (HCL) but with important differences | ||
*Marked splenomegaly and marrow infiltration result in left flank discomfort, fatigue, and susceptibility to infections | *Marked splenomegaly and marrow infiltration result in left flank discomfort, fatigue, and susceptibility to infections | ||
*Most respond poorly to monotherapy with a purine analog or interferon alpha (used for HCL) | *Most respond poorly to monotherapy with a purine analog or interferon alpha (used for HCL) | ||
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|Positive||CD11c, CD72, CD103 | |Positive||CD11c, CD72, CD103 | ||
|- | |- | ||
|Negative ([[Hairy | |Negative ([[HAEM5:Hairy cell leukaemia|HCL]] markers)||CD25, CD123, annexin A1, TRAP, BRAF V600E | ||
|- | |- | ||
|Negative | |Negative | ||
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==Links== | ==Links== | ||
*[[Hairy | *[[HAEM5:Hairy cell leukaemia]] | ||
*[[Splenic | *[[HAEM5:Splenic diffuse red pulp small B-cell lymphoma]] | ||
==References== | ==References== | ||