HAEM5:B lymphoblastic leukaemia/lymphoma with ETV6::RUNX1 fusion: Difference between revisions

{{DISPLAYTITLE:B lymphoblastic leukaemia/lymphoma with ETV6::RUNX1 fusion}}

[[HAEM5:Table_of_Contents|Haematolymphoid Tumours (WHO Classification, 5th ed.)]]

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Marilena Melas, PhD; Yassmine Akkari, PhD, FACMG  

==WHO Classification of Disease==

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|Acceptable

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|Not Recommended

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* Chromosomal Rearrangements (Gene Fusions)

* Individual Region Genomic Gain/Loss/LOH

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The 12p13 deletion is the most common accompanying abnormality found in approximately 40% of cases resulting in the loss of ''ETV6'' on the chromosome not involved in the rearrangement. In addition, deletion of the ''CDKN2A/B'' locus on 9p21 or the ''PAX5'' gene at 9p13 can be both seen in about a quarter of patients [29–32] . These abnormalities, as well as loss of 6q and gain of chromosome 16, are thought to be among the earliest genomic aberrations in t(12;21) positive B-ALL  

!Chromosomal Pattern

!Molecular Pathogenesis

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|<span class="blue-text">EXAMPLE:</span>

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|<span class="blue-text">EXAMPLE:</span>''EGFR''

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==Notes==

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