HAEM5:Large B-cell lymphoma with IRF4 rearrangement: Difference between revisions
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{{Under Construction}} | {{Under Construction}} | ||
<blockquote class= | <blockquote class="blockedit">{{Box-round|title=Content Update To WHO 5th Edition Classification Is In Process; Content Below is Based on WHO 4th Edition Classification|This page was converted to the new template on 2023-12-07. The original page can be found at [[HAEM4:Large B-cell Lymphoma with IRF4 Rearrangement]]. | ||
}}</blockquote> | }}</blockquote> | ||
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*Afia Hasnain, MBBS, PhD | *Afia Hasnain, MBBS, PhD | ||
==WHO Classification of Disease== | ==WHO Classification of Disease== | ||
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|} | |} | ||
== | ==Related Terminology== | ||
{| class="wikitable" | {| class="wikitable" | ||
|+ | |+ | ||
|Acceptable | |Acceptable | ||
| | |N/A | ||
|- | |- | ||
|Not Recommended | |Not Recommended | ||
| | |N/A | ||
|} | |} | ||
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|} | |} | ||
<blockquote class= | <blockquote class="blockedit">{{Box-round|title=v4:Chromosomal Rearrangements (Gene Fusions)|The content below was from the old template. Please incorporate above.}}</blockquote> | ||
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|} | |} | ||
<blockquote class= | <blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":0">{{Cite journal|last=Salaverria|first=Itziar|last2=Philipp|first2=Claudia|last3=Oschlies|first3=Ilske|last4=Kohler|first4=Christian W.|last5=Kreuz|first5=Markus|last6=Szczepanowski|first6=Monika|last7=Burkhardt|first7=Birgit|last8=Trautmann|first8=Heiko|last9=Gesk|first9=Stefan|date=2011-07-07|title=Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults|url=https://ashpublications.org/blood/article/118/1/139/28404/Translocations-activating-IRF4-identify-a-subtype|journal=Blood|language=en|volume=118|issue=1|pages=139–147|doi=10.1182/blood-2011-01-330795|issn=0006-4971}}</ref><ref>{{Cite journal|last=Ramis-Zaldivar|first=Joan Enric|last2=Gonzalez-Farré|first2=Blanca|last3=Balagué|first3=Olga|last4=Celis|first4=Verónica|last5=Nadeu|first5=Ferran|last6=Salmerón-Villalobos|first6=Julia|last7=Andrés|first7=Mara|last8=Martin-Guerrero|first8=Idoia|last9=Garrido-Pontnou|first9=Marta|date=01 23, 2020|title=Distinct molecular profile of IRF4-rearranged large B-cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/31738823|journal=Blood|volume=135|issue=4|pages=274–286|doi=10.1182/blood.2019002699|issn=1528-0020|pmc=6978155|pmid=31738823}}</ref><blockquote class="blockedit"> | ||
<center><span style="color:Maroon">'''End of V4 Section'''</span> | <center><span style="color:Maroon">'''End of V4 Section'''</span> | ||
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<blockquote class= | <blockquote class="blockedit">{{Box-round|title=v4:Clinical Significance (Diagnosis, Prognosis and Therapeutic Implications).|Please incorporate this section into the relevant tables found in: | ||
* Chromosomal Rearrangements (Gene Fusions) | * Chromosomal Rearrangements (Gene Fusions) | ||
* Individual Region Genomic Gain/Loss/LOH | * Individual Region Genomic Gain/Loss/LOH | ||
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<blockquote class= | <blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":0" /><ref name=":2">{{Cite journal|last=Chisholm|first=Karen M.|last2=Mohlman|first2=Jeffrey|last3=Liew|first3=Michael|last4=Termuhlen|first4=Amanda|last5=Cairo|first5=Mitchell S.|last6=Gross|first6=Thomas G.|last7=Perkins|first7=Sherrie L.|last8=Miles|first8=Rodney R.|date=2019-08|title=IRF4 translocation status in pediatric follicular and diffuse large B‐cell lymphoma patients enrolled in Children's Oncology Group trials|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/pbc.27770|journal=Pediatric Blood & Cancer|language=en|volume=66|issue=8|doi=10.1002/pbc.27770|issn=1545-5009}}</ref><blockquote class="blockedit"> | ||
<center><span style="color:Maroon">'''End of V4 Section'''</span> | <center><span style="color:Maroon">'''End of V4 Section'''</span> | ||
---- | ---- | ||
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{| class="wikitable sortable" | {| class="wikitable sortable" | ||
|- | |- | ||
!Chr #!! | !Chr #!!Gain, Loss, Amp, LOH!!Minimal Region Cytoband and/or Genomic Coordinates [Genome Build; Size]!!Relevant Gene(s) | ||
! | !Diagnostic, Prognostic, and Therapeutic Significance - D, P, T | ||
! | !Established Clinical Significance Per Guidelines - Yes or No (Source) | ||
! | !Clinical Relevance Details/Other Notes | ||
|- | |- | ||
|<span class="blue-text">EXAMPLE:</span> | |<span class="blue-text">EXAMPLE:</span> | ||
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|} | |} | ||
<blockquote class= | <blockquote class="blockedit">{{Box-round|title=v4:Genomic Gain/Loss/LOH|The content below was from the old template. Please incorporate above.}}</blockquote> | ||
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<blockquote class= | <blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref>{{Cite journal|last=Salaverria|first=Itziar|last2=Martin-Guerrero|first2=Idoia|last3=Burkhardt|first3=Birgit|last4=Kreuz|first4=Markus|last5=Zenz|first5=Thorsten|last6=Oschlies|first6=Ilske|last7=Arnold|first7=Norbert|last8=Baudis|first8=Michael|last9=Bens|first9=Susanne|date=2013-02|title=High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas|url=https://pubmed.ncbi.nlm.nih.gov/23073988|journal=Genes, Chromosomes & Cancer|volume=52|issue=2|pages=150–155|doi=10.1002/gcc.22014|issn=1098-2264|pmid=23073988}}</ref><blockquote class="blockedit"> | ||
<center><span style="color:Maroon">'''End of V4 Section'''</span> | <center><span style="color:Maroon">'''End of V4 Section'''</span> | ||
---- | ---- | ||
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!Chromosomal Pattern | !Chromosomal Pattern | ||
!Molecular Pathogenesis | !Molecular Pathogenesis | ||
! | !Prevalence - | ||
Common >20%, Recurrent 5-20% or Rare <5% (Disease) | |||
! | !Diagnostic, Prognostic, and Therapeutic Significance - D, P, T | ||
! | !Established Clinical Significance Per Guidelines - Yes or No (Source) | ||
! | !Clinical Relevance Details/Other Notes | ||
|- | |- | ||
|<span class="blue-text">EXAMPLE:</span> | |<span class="blue-text">EXAMPLE:</span> | ||
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|} | |} | ||
<blockquote class= | <blockquote class="blockedit">{{Box-round|title=v4:Characteristic Chromosomal Aberrations / Patterns|The content below was from the old template. Please incorporate above.}}</blockquote> | ||
''IRF4'' Rearrangement<ref name=":0" /> | ''IRF4'' Rearrangement<ref name=":0" /> | ||
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{| class="wikitable sortable" | {| class="wikitable sortable" | ||
|- | |- | ||
!Gene!! | !Gene!!Genetic Alteration!!Tumor Suppressor Gene, Oncogene, Other!!Prevalence - | ||
Common >20%, Recurrent 5-20% or Rare <5% (Disease) | |||
! | !Diagnostic, Prognostic, and Therapeutic Significance - D, P, T | ||
! | !Established Clinical Significance Per Guidelines - Yes or No (Source) | ||
! | !Clinical Relevance Details/Other Notes | ||
|- | |- | ||
|<span class="blue-text">EXAMPLE:</span>''EGFR'' | |<span class="blue-text">EXAMPLE:</span>''EGFR'' | ||
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|}Note: A more extensive list of mutations can be found in [https://www.cbioportal.org/ <u>cBioportal</u>], [https://cancer.sanger.ac.uk/cosmic <u>COSMIC</u>], and/or other databases. When applicable, gene-specific pages within the CCGA site directly link to pertinent external content. | |}Note: A more extensive list of mutations can be found in [https://www.cbioportal.org/ <u>cBioportal</u>], [https://cancer.sanger.ac.uk/cosmic <u>COSMIC</u>], and/or other databases. When applicable, gene-specific pages within the CCGA site directly link to pertinent external content. | ||
<blockquote class= | <blockquote class="blockedit">{{Box-round|title=v4:Gene Mutations (SNV/INDEL)|The content below was from the old template. Please incorporate above.}}</blockquote> | ||
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<blockquote class= | <blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":3">{{Cite journal|last=Ramis-Zaldivar|first=Joan Enric|last2=Gonzalez-Farré|first2=Blanca|last3=Balagué|first3=Olga|last4=Celis|first4=Verónica|last5=Nadeu|first5=Ferran|last6=Salmerón-Villalobos|first6=Julia|last7=Andrés|first7=Mara|last8=Martin-Guerrero|first8=Idoia|last9=Garrido-Pontnou|first9=Marta|date=01 23, 2020|title=Distinct molecular profile of IRF4-rearranged large B-cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/31738823|journal=Blood|volume=135|issue=4|pages=274–286|doi=10.1182/blood.2019002699|issn=1528-0020|pmc=6978155|pmid=31738823}}</ref><blockquote class="blockedit"> | ||
<center><span style="color:Maroon">'''End of V4 Section'''</span> | <center><span style="color:Maroon">'''End of V4 Section'''</span> | ||
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<blockquote class= | <blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":2" /><ref name=":3" /><blockquote class="blockedit"> | ||
<center><span style="color:Maroon">'''End of V4 Section'''</span> | <center><span style="color:Maroon">'''End of V4 Section'''</span> | ||
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|} | |} | ||
<blockquote class= | <blockquote class="blockedit">{{Box-round|title=v4:Genes and Main Pathways Involved|The content below was from the old template. Please incorporate above.}}</blockquote> | ||
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<blockquote class= | <blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":3" /><blockquote class="blockedit"> | ||
<center><span style="color:Maroon">'''End of V4 Section'''</span> | <center><span style="color:Maroon">'''End of V4 Section'''</span> | ||
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<blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref>{{Cite journal|last=Salaverria|first=Itziar|last2=Martin-Guerrero|first2=Idoia|last3=Burkhardt|first3=Birgit|last4=Kreuz|first4=Markus|last5=Zenz|first5=Thorsten|last6=Oschlies|first6=Ilske|last7=Arnold|first7=Norbert|last8=Baudis|first8=Michael|last9=Bens|first9=Susanne|date=2013-02|title=High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas|url=https://pubmed.ncbi.nlm.nih.gov/23073988|journal=Genes, Chromosomes & Cancer|volume=52|issue=2|pages=150–155|doi=10.1002/gcc.22014|issn=1098-2264|pmid=23073988}}</ref><blockquote class="blockedit"> | |||
<blockquote class= | |||
<center><span style="color:Maroon">'''End of V4 Section'''</span> | <center><span style="color:Maroon">'''End of V4 Section'''</span> | ||
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<blockquote class= | <blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":2" /><blockquote class="blockedit"> | ||
<center><span style="color:Maroon">'''End of V4 Section'''</span> | <center><span style="color:Maroon">'''End of V4 Section'''</span> | ||
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(use the "Cite" icon at the top of the page) <span style="color:#0070C0">(''Instructions: Add each reference into the text above by clicking where you want to insert the reference, selecting the “Cite” icon at the top of the wiki page, and using the “Automatic” tab option to search by PMID to select the reference to insert. If a PMID is not available, such as for a book, please use the “Cite” icon, select “Manual” and then “Basic Form”, and include the entire reference. To insert the same reference again later in the page, select the “Cite” icon and “Re-use” to find the reference; DO NOT insert the same reference twice using the “Automatic” tab as it will be treated as two separate references. The reference list in this section will be automatically generated and sorted''</span><span style="color:#0070C0">''.''</span><span style="color:#0070C0">)</span> <references /> | (use the "Cite" icon at the top of the page) <span style="color:#0070C0">(''Instructions: Add each reference into the text above by clicking where you want to insert the reference, selecting the “Cite” icon at the top of the wiki page, and using the “Automatic” tab option to search by PMID to select the reference to insert. If a PMID is not available, such as for a book, please use the “Cite” icon, select “Manual” and then “Basic Form”, and include the entire reference. To insert the same reference again later in the page, select the “Cite” icon and “Re-use” to find the reference; DO NOT insert the same reference twice using the “Automatic” tab as it will be treated as two separate references. The reference list in this section will be automatically generated and sorted''</span><span style="color:#0070C0">''.''</span><span style="color:#0070C0">)</span> <references /> | ||
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==Notes== | ==Notes== | ||
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<nowiki>*</nowiki>''Citation of this Page'': “Large B-cell lymphoma with IRF4 rearrangement”. Compendium of Cancer Genome Aberrations (CCGA), Cancer Genomics Consortium (CGC), updated {{REVISIONMONTH}}/{{REVISIONDAY}}/{{REVISIONYEAR}}, <nowiki>https://ccga.io/index.php/HAEM5:Large_B-cell_lymphoma_with_IRF4_rearrangement</nowiki>. | <nowiki>*</nowiki>''Citation of this Page'': “Large B-cell lymphoma with IRF4 rearrangement”. Compendium of Cancer Genome Aberrations (CCGA), Cancer Genomics Consortium (CGC), updated {{REVISIONMONTH}}/{{REVISIONDAY}}/{{REVISIONYEAR}}, <nowiki>https://ccga.io/index.php/HAEM5:Large_B-cell_lymphoma_with_IRF4_rearrangement</nowiki>. | ||
[[Category:HAEM5]][[Category:DISEASE]][[Category:Diseases L]] | [[Category:HAEM5]] | ||
[[Category:DISEASE]] | |||
[[Category:Diseases L]] | |||