HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli: Difference between revisions

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Note: consider content on the overview page: Splenic B-cell Lymphoma/Leukemia, Unclassifiable

*Snehal Patel, MD, PhD

==WHO Classification of Disease==

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|Acceptable

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|Not Recommended

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*No consistent gene fusions

* Chromosomal Rearrangements (Gene Fusions)

* Individual Region Genomic Gain/Loss/LOH

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|<span class="blue-text">EXAMPLE:</span>

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!Chromosomal Pattern

!Molecular Pathogenesis

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|<span class="blue-text">EXAMPLE:</span>

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*Preferential utilization of IGHV4-34 (Immunoglobulin heavy chain variable segment) in 40%<ref>{{Cite journal|last=Xi|first=Liqiang|last2=Arons|first2=Evgeny|last3=Navarro|first3=Winnifred|last4=Calvo|first4=Katherine R.|last5=Stetler-Stevenson|first5=Maryalice|last6=Raffeld|first6=Mark|last7=Kreitman|first7=Robert J.|date=2012|title=Both variant and IGHV4-34–expressing hairy cell leukemia lack the BRAF V600E mutation|url=https://ashpublications.org/blood/article/119/14/3330/29588/Both-variant-and-IGHV434expressing-hairy-cell|journal=Blood|language=en|volume=119|issue=14|pages=3330–3332|doi=10.1182/blood-2011-09-379339|issn=0006-4971|pmc=PMC3321859|pmid=22210875}}</ref> and has clinical implications<ref name=":4">{{Cite journal|last=Arons|first=Evgeny|last2=Suntum|first2=Tara|last3=Stetler-Stevenson|first3=Maryalice|last4=Kreitman|first4=Robert J.|date=2009|title=VH4-34+ hairy cell leukemia, a new variant with poor prognosis despite standard therapy|url=https://ashpublications.org/blood/article/114/21/4687/26430/VH434-hairy-cell-leukemia-a-new-variant-with-poor|journal=Blood|language=en|volume=114|issue=21|pages=4687–4695|doi=10.1182/blood-2009-01-201731|issn=0006-4971|pmc=PMC2780305|pmid=19745070}}</ref>

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|<span class="blue-text">EXAMPLE:</span>''EGFR''

|}Note: A more extensive list of mutations can be found in [https://www.cbioportal.org/ <u>cBioportal</u>], [https://cancer.sanger.ac.uk/cosmic <u>COSMIC</u>], and/or other databases. When applicable, gene-specific pages within the CCGA site directly link to pertinent external content.

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!Molecular feature

(use the "Cite" icon at the top of the page) <span style="color:#0070C0">(''Instructions: Add each reference into the text above by clicking where you want to insert the reference, selecting the “Cite” icon at the top of the wiki page, and using the “Automatic” tab option to search by PMID to select the reference to insert. If a PMID is not available, such as for a book, please use the “Cite” icon, select “Manual” and then “Basic Form”, and include the entire reference. To insert the same reference again later in the page, select the “Cite” icon and “Re-use” to find the reference; DO NOT insert the same reference twice using the “Automatic” tab as it will be treated as two separate references. The reference list in this section will be automatically generated and sorted''</span><span style="color:#0070C0">''.''</span><span style="color:#0070C0">)</span> <references />

==Notes==

          

<nowiki>*</nowiki>''Citation of this Page'': “Splenic B-cell lymphoma/leukaemia with prominent nucleoli”. Compendium of Cancer Genome Aberrations (CCGA), Cancer Genomics Consortium (CGC), updated {{REVISIONMONTH}}/{{REVISIONDAY}}/{{REVISIONYEAR}}, <nowiki>https://ccga.io/index.php/HAEM5:Splenic_B-cell_lymphoma/leukaemia_with_prominent_nucleoli</nowiki>.