Recurrent Genomic Alterations in Pediatric and Adult Central Nervous System Tumors Detected by Chromosomal Microarray: Difference between revisions
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! BROAD ABERRATIONS (>10Mb) | ! BROAD ABERRATIONS (>10Mb) | ||
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|Adults and pediatric tumors show similar CNVs; CDKN2A/CDKN2B loss may correlate with anaplastic histology | |Adults and pediatric tumors show similar CNVs; CDKN2A/CDKN2B loss may correlate with anaplastic histology | ||
|PMID:23442159; PMID:28181325 | |PMID:23442159; PMID:28181325 | ||
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|Ganglioglioma | |||
|'''Gain:''' polysomy 5, polysomy 7, 10p<br> | |||
'''Loss:''' 1p loss, monosomy (with focal CDKN2A loss) | |||
|'''Mutation:''' BRAF V600E , TSC1, TSC2, FGFR1, FGFR2, KRAS | |||
|Generally indolent tumors; surgical resection can be curative | |||
|PMID:23442159; PMID:25764012; PMID:29880043 | |||
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|Angiocentric glioma | |||
|'''Loss:''' 6q24-q25 | |||
|'''Fusion:''' MYB-QKI rearrangement/deletion (classic histology)<br> | |||
'''Rearrangement:''' MYB alone (atypical histology)<br> | |||
'''Amplification:''' MYB (atypical histology) | |||
|Generally indolent tumors; surgical resection can be curative | |||
|PMID:26829751 | |||
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|Dysembryoplastic neuroepithelial tumor (DNET) | |||
|No specific changes | |||
|'''Mutation:''' intragenic duplication or mutation FGFR1; BRAF V600E | |||
|Rare in adults; Benign with excellent prognosis even with subtotal resection | |||
|PMID:26920151; PMID:23442159; PMID:21937911 | |||
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|Rosette forming glioneuronal tumor | |||
|'''Gain:'''1q , 7, 9, 16<br> | |||
'''Loss:''' 1p<br> | |||
'''Amplification:''' 9q34.2, 19p13.3 | |||
|'''Fusion:''' KIAA1549-BRAF fusion (via 3'BRAF duplication)<br> | |||
'''Mutation:''' PIK3CA, FGFR1<br> | |||
'''Amplification:''' SBNO2 | |||
|Generally indolent tumors; surgical resection can be curative | |||
|PMID:27893178; PMID:26371886 | |||
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|Infiltrating Gliomas | |||
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