HAEM4:Splenic B-cell Lymphoma/Leukemia, Unclassifiable: Difference between revisions
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==General Disease Overview / Description of Cancer Category== | ==General Disease Overview / Description of Cancer Category== | ||
Splenic B-cell lymphoma/leukemia, Unclassifiable (SBLL-U) includes primary splenic lymphomas that cannot be better classified into other [[Mature B-Cell Neoplasms|mature B-cell neoplasms]] and are overall rare, accounting for <1% of lymphomas. Two entities in this category, [[ | Splenic B-cell lymphoma/leukemia, Unclassifiable (SBLL-U) includes primary splenic lymphomas that cannot be better classified into other [[HAEM4:Mature B-Cell Neoplasms|mature B-cell neoplasms]] and are overall rare, accounting for <1% of lymphomas. Two entities in this category, [[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli|hairy cell leukemia variant]] (HCL-v) and [[HAEM5:Splenic diffuse red pulp small B-cell lymphoma|splenic diffuse red pulp small B-cell lymphoma]] (SDRPL) may represent distinct entities and are designated as provisional entities in the 2017 WHO. Recent molecular evidence suggests that they are distinct from each other and from [[HAEM5:Splenic marginal zone lymphoma|splenic marginal zone lymphoma]] and [[HAEM5:Hairy cell leukaemia|hairy cell leukemia]], which which the have overlapping clinical, morphologic, and immunophenotypic features. Primary splenic lymphomas that cannot be classified as HCL-v or SDRPL should be classified as splenic B-cell lymphoma/leukemia, Unclassifiable. | ||
==WHO Classification Pages (Includes Links to Content)== | ==WHO Classification Pages (Includes Links to Content)== | ||
* [[Splenic | * [[HAEM5:Splenic diffuse red pulp small B-cell lymphoma]] | ||
* [[ | * [[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli]] | ||
==Other Related Pages (Includes Links to Content)== | ==Other Related Pages (Includes Links to Content)== | ||
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Differential diagnosis: other small B-cell lymphomas with cytoplasmic projections and significant splenic involvement | Differential diagnosis: other small B-cell lymphomas with cytoplasmic projections and significant splenic involvement | ||
* [[Splenic | * [[HAEM5:Splenic marginal zone lymphoma]] | ||
* [[Hairy | * [[HAEM5:Hairy cell leukaemia]] | ||
==Additional Information== | ==Additional Information== | ||