HAEM4:Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN), Unclassifiable: Difference between revisions
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When an underlying MPN has not been identified, the category of MDS/MPN-U is appropriate. <ref name=":0" /> | When an underlying MPN has not been identified, the category of MDS/MPN-U is appropriate. <ref name=":0" /> | ||
Cases with features of MDS/MPN-U may arise due to prior exposure to treatment and are included in the [[ | Cases with features of MDS/MPN-U may arise due to prior exposure to treatment and are included in the [[HAEM5:Myeloid neoplasm post cytotoxic therapy|Therapy-related myeloid neoplasms]] (t-MN). | ||
Well-defined MPN which subsequently develop dysplastic features and progress to a more aggressive phase are excluded from this category. | Well-defined MPN which subsequently develop dysplastic features and progress to a more aggressive phase are excluded from this category. | ||
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==Clinical Features== | ==Clinical Features== | ||
*Overlap with [[Myelodysplastic Syndromes (MDS)|MDS]] and [[Myeloproliferative Neoplasms (MPN)|MPN]] <ref name=":0" /> | *Overlap with [[HAEM4:Myelodysplastic Syndromes (MDS)|MDS]] and [[HAEM4:Myeloproliferative Neoplasms (MPN)|MPN]] <ref name=":0" /> | ||
*Clinically the most heterogeneous of the MDS/MPN <ref name=":3" /> | *Clinically the most heterogeneous of the MDS/MPN <ref name=":3" /> | ||
*Does not have features that define it as belonging to any of the other categories of MDS/MPN <ref name=":0" /><ref name=":1" /> | *Does not have features that define it as belonging to any of the other categories of MDS/MPN <ref name=":0" /><ref name=":1" /> | ||
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==Immunophenotype== | ==Immunophenotype== | ||
May be similar to that of [[Myelodysplastic Syndromes (MDS)|MDS]] or [[Myeloproliferative Neoplasms (MPN)|MPN]] <ref name=":0" /> | May be similar to that of [[HAEM4:Myelodysplastic Syndromes (MDS)|MDS]] or [[HAEM4:Myeloproliferative Neoplasms (MPN)|MPN]] <ref name=":0" /> | ||
==Chromosomal Rearrangements (Gene Fusions)== | ==Chromosomal Rearrangements (Gene Fusions)== | ||