HAEM5:T-prolymphocytic leukaemia: Difference between revisions
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|Yes | |Yes | ||
|No | |No | ||
|Major diagnostic criteria | |Major diagnostic criteria | ||
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|}Note: A more extensive list of mutations can be found in cBioportal (https://www.cbioportal.org/), COSMIC (https://cancer.sanger.ac.uk/cosmic), ICGC (https://dcc.icgc.org/) and/or other databases. When applicable, gene-specific pages within the CCGA site directly link to pertinent external content. | |}Note: A more extensive list of mutations can be found in cBioportal (https://www.cbioportal.org/), COSMIC (https://cancer.sanger.ac.uk/cosmic), ICGC (https://dcc.icgc.org/) and/or other databases. When applicable, gene-specific pages within the CCGA site directly link to pertinent external content. | ||
==Epigenomic Alterations== | ==Epigenomic Alterations== | ||
Research indicates that epigenetic modifications in the regulatory regions of key oncogenes and genes involved in DNA damage response and T-cell receptor regulation are clearly present. These changes are closely associated with the transcriptional dysregulation that forms the core lesions of T-PLL.<ref>{{Cite journal|last=Tian|first=Shulan|last2=Zhang|first2=Henan|last3=Zhang|first3=Pan|last4=Kalmbach|first4=Michael|last5=Lee|first5=Jeong-Heon|last6=Ordog|first6=Tamas|last7=Hampel|first7=Paul J.|last8=Call|first8=Timothy G.|last9=Witzig|first9=Thomas E.|date=2021-04-15|title=Epigenetic alteration contributes to the transcriptional reprogramming in T-cell prolymphocytic leukemia|url=https://pubmed.ncbi.nlm.nih.gov/33859327|journal=Scientific Reports|volume=11|issue=1|pages=8318|doi=10.1038/s41598-021-87890-9|issn=2045-2322|pmc=8050249|pmid=33859327}}</ref> | |||
==Genes and Main Pathways Involved== | ==Genes and Main Pathways Involved== | ||
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==References== | ==References== | ||
<references /> | <references /> | ||
==Notes== | ==Notes== | ||