HAEM5:ALK-positive anaplastic large cell lymphoma: Difference between revisions
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|'''Laboratory Findings''' | |'''Laboratory Findings''' | ||
|Noncontributory | |Noncontributory | ||
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|Positive (universal) - Cellular location of ALK staining varies depending on ALK translocation partner. In the most common t(2;5), most cases show both cytoplasmic and nuclear||ALK | |Positive (universal) - Cellular location of ALK staining varies depending on ALK translocation partner. In the most common t(2;5), most cases show both cytoplasmic and nuclear||ALK | ||
|- | |- | ||
|Positive (subset) ||EMA | |Positive (subset)||EMA | ||
|- | |- | ||
|Negative - >75% of cases are CD3-negative||CD3 | |Negative - >75% of cases are CD3-negative||CD3 | ||
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|Granzyme B | |Granzyme B | ||
|- | |- | ||
|Positive | |Positive | ||
|Perforin | |Perforin | ||
|- | |- | ||
|Variably positive | |Variably positive | ||
|CD45 | |CD45 | ||
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|t(2;5)(p23;q35)||3' ''ALK'' / 5' ''NPM1''<ref name=":20" />||''NPM1::ALK'' fusion protein||84%<ref name=":0" /> | |t(2;5)(p23;q35)||3' ''ALK'' / 5' ''NPM1''<ref name=":20" />||''NPM1::ALK'' fusion protein||84%<ref name=":0" /> | ||
|No | |No | ||
|No | |No | ||
|Yes | |Yes | ||
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|2q | |2q | ||
|Gain | |Gain | ||
| | |Chr 2:29,192,774-29,921,586 | ||
|EXAMPLE | |EXAMPLE | ||
chr7 | chr7 | ||
| | |No | ||
|Yes | |Yes | ||
|No | |No | ||