HAEM5:Aggressive NK-cell leukaemia: Difference between revisions

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 ==Primary Author(s)*==
-Rabail Aslam, MD, Shanelle De Lancy, MD, Shashirekha Shetty, PhD
+Shanelle De Lancy, MD, Rabail Aslam, MD, Shashirekha Shetty, PhD
 Case Western Reserve University, Cleveland, OH
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 ==WHO Classification of Disease==
-'''''Mature T- and NK-cell neoplasms'''''
+Aggressive NK-cell leukaemia
 ==Definition / Description of Disease==
+Aggressive NK-cell leukaemia is a malignant proliferation of NK-cells, often associated with EBV infection, however, a subset of cases could be EBV negative. The disease has an extremely aggressive clinical course with poor response to chemotherapy, frequent relapses noted in patient who have had previously achieved complete remission (+/- bone marrow transplantation).
-*Proliferation of NK-cells
-*Associated with EBV infection, but EBV may be negative in a subset of patients
-*Aggressive clinical course with poor response to chemotherapy
-*Relapse common in patients that achieve complete remission (+/- bone marrow transplantation)
 ==Synonyms / Terminology==
-'''''Aggressive NK-cell leukaemia/lymphoma'''''
+Aggressive NK-cell leukaemia/lymphoma
 ==Epidemiology / Prevalence==