HAEM5:Aggressive NK-cell leukaemia: Difference between revisions
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Circulating FASL | Circulating FASL | ||
Variable | Variable percentage of circulating leukemic cells | ||
Anemia, neutropenia, thrombocytopenia | Anemia, neutropenia, thrombocytopenia | ||
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==Sites of Involvement== | ==Sites of Involvement== | ||
Peripheral blood, bone marrow, liver, spleen, and lymph nodes. Extranodal involvement | Peripheral blood, bone marrow, liver, spleen, and lymph nodes. Extranodal involvement sites are organs including skin, lungs, soft tissue and omentum can be seen.<ref name=":5" /> | ||
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'''Peripheral Blood''' | '''Peripheral Blood''' | ||
*Variable; May appear as: | *Variable; May appear as: | ||
**Normal large granular lymphocytes or | **Normal large granular lymphocytes or | ||
**Intermediate to large cells with atypical nuclei (enlarged, irregular folding, open chromatin or distinct nucleoli) and moderate pale or lightly basophilic cytoplasm containing fine, coarse or no azurophilic granules | **Intermediate to large cells with atypical nuclei (enlarged, irregular folding, open chromatin or distinct nucleoli) and moderate pale or lightly basophilic cytoplasm containing fine, coarse or no azurophilic granules.<ref name=":1" /> | ||
'''Bone Marrow:''' | '''Bone Marrow:''' | ||
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==Immunophenotype== | ==Immunophenotype== | ||
The leukaemic cells ....... | |||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
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