Compendium of Cancer Genome Aberrations

HAEM5:ALK-positive anaplastic large cell lymphoma: Difference between revisions

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!Gene; Genetic Alteration!!Pathway!!Pathophysiologic Outcome
!Gene; Genetic Alteration!!Pathway!!Pathophysiologic Outcome
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|-
|ALK; fusion protein derivatives  
|ALK; fusion protein derivatives
|Ras-ERK:
|Ras-ERK
|Increased cell growth and proliferation
|Increased cell growth and proliferation
|-
|-
|EXAMPLE: CDKN2A; Inactivating mutations
|ALK; fusion protein derivatives
|EXAMPLE: Cell cycle regulation
|JAK/STAT3
|EXAMPLE: Unregulated cell division
|Cell survival and phenotypic changes
|-
|-
|EXAMPLE:  KMT2C and ARID1A; Inactivating mutations
|ALK; fusion protein derivatives
|EXAMPLE:  Histone modification, chromatin remodeling
|PI3K/AKT/mTOR
|EXAMPLE:  Abnormal gene expression program
|Cell survival and phenotypic changes
|}
|}


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