HAEM5:Acute myeloid leukaemia with maturation: Difference between revisions

Usually presents with symptoms of bone marrow failure, including anemia, thrombocytopenia and neutropenia.  There is also variability in the white blood cell and blast counts<ref name=":0" />.

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==Sites of Involvement==

There is currently no known recurrent chromosomal abnormality associated with this entity.

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* Individual Region Genomic Gain/Loss/LOH

* Characteristic Chromosomal Patterns

The differential diagnosis includes 1) MDS with excess blasts in cases with a low blast percentage, 2) AML without Maturation in cases with a high blast percentage, and 3) [[HAEM5:Acute myelomonocytic leukaemia]] in cases with increased monocytes.  Of note, [[Acute Myeloid Leukemia (AML) with t(8;21)(q22;q22.1);RUNX1-RUNX1T1]] typically has overlapping histologic features as AML with Maturation, but the former should be classified according to its genetic abnormality (i.e. as a subcategory of the entity [[HAEM4:Acute Myeloid Leukemia (AML) with Recurrent Genetic Abnormalities]]).

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==Individual Region Genomic Gain / Loss / LOH==

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There is currently no known recurrent chromosomal abnormality associated with this entity.

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==Characteristic Chromosomal Patterns==

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There is currently no known recurrent chromosomal abnormality associated with this entity.

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==Gene Mutations (SNV / INDEL)==

Currently there is currently no known recurrent gene mutations associated with this entity.

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==Epigenomic Alterations==

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Unknown

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==Genetic Diagnostic Testing Methods==