HAEM5:Splenic marginal zone lymphoma: Difference between revisions
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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":2" /><ref name=":6">{{Cite journal|last=Tsd|first=Santos|last2=Rs|first2=Tavares|last3=Dlc|first3=Farias|date=2017|title=Splenic Marginal Zone Lymphoma: A Literature Review of Diagnostic and Therapeutic Challenges|url=https://pubmed.ncbi.nlm.nih.gov/28577652/|language=en|doi=10.1016/j.bjhh.2016.09.014|pmc=PMC5457460|pmid=28577652}}</ref></blockquote> | <blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":2" /><ref name=":6">{{Cite journal|last=Tsd|first=Santos|last2=Rs|first2=Tavares|last3=Dlc|first3=Farias|date=2017|title=Splenic Marginal Zone Lymphoma: A Literature Review of Diagnostic and Therapeutic Challenges|url=https://pubmed.ncbi.nlm.nih.gov/28577652/|language=en|doi=10.1016/j.bjhh.2016.09.014|pmc=PMC5457460|pmid=28577652}}</ref><blockquote class="blockedit"> | ||
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==Clinical Features== | ==Clinical Features== | ||
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'''Signs & Symptoms''' | '''Signs & Symptoms''' | ||
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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":2" /><ref name=":6" /></blockquote> | <blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":2" /><ref name=":6" /><blockquote class="blockedit"> | ||
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==Sites of Involvement== | ==Sites of Involvement== | ||
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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":2" /><ref name=":6" /></blockquote> | <blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":2" /><ref name=":6" /><blockquote class="blockedit"> | ||
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==Morphologic Features== | ==Morphologic Features== | ||
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==Immunophenotype== | ==Immunophenotype== | ||
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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":2" /><ref name=":6" /></blockquote> | <blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":2" /><ref name=":6" /><blockquote class="blockedit"> | ||
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==Chromosomal Rearrangements (Gene Fusions)== | ==Chromosomal Rearrangements (Gene Fusions)== | ||
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*Rare but (some) recurrent translocations/gene fusions: | *Rare but (some) recurrent translocations/gene fusions: | ||
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* | * | ||
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* Individual Region Genomic Gain/Loss/LOH | * Individual Region Genomic Gain/Loss/LOH | ||
* Characteristic Chromosomal Patterns | * Characteristic Chromosomal Patterns | ||
* Gene Mutations (SNV/INDEL)}} | * Gene Mutations (SNV/INDEL)}}</blockquote> | ||
{| class="wikitable" | {| class="wikitable" | ||
!Alteration | !Alteration | ||
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<nowiki>*</nowiki>Cases previously reported as SMZL with IGH-CCND1 fusion should now be classified as MCL | <nowiki>*</nowiki>Cases previously reported as SMZL with IGH-CCND1 fusion should now be classified as MCL | ||
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==Individual Region Genomic Gain / Loss / LOH== | ==Individual Region Genomic Gain / Loss / LOH== | ||
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==Characteristic Chromosomal Patterns== | ==Characteristic Chromosomal Patterns== | ||
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*Ig gene rearrangements | *Ig gene rearrangements | ||
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==Gene Mutations (SNV / INDEL)== | ==Gene Mutations (SNV / INDEL)== | ||
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{| class="wikitable sortable" | {| class="wikitable sortable" | ||
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<nowiki>*</nowiki>Specific mutations in these genes may be found in [https://www.cbioportal.org/ cBioPortal] or [https://cancer.sanger.ac.uk/cosmic COSMIC]. | <nowiki>*</nowiki>Specific mutations in these genes may be found in [https://www.cbioportal.org/ cBioPortal] or [https://cancer.sanger.ac.uk/cosmic COSMIC]. | ||
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==Epigenomic Alterations== | ==Epigenomic Alterations== | ||
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{| class="wikitable" | {| class="wikitable" | ||
!Molecular Feature | !Molecular Feature | ||
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==Genetic Diagnostic Testing Methods== | ==Genetic Diagnostic Testing Methods== | ||