HAEM5:Splenic diffuse red pulp small B-cell lymphoma: Difference between revisions

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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":0">{{Cite journal|last=T|first=Vig|last2=Ta|first2=Kodiatte|last3=Mt|first3=Manipadam|last4=Fn|first4=Aboobacker|date=2018|title=A Rare Case of Splenic Diffuse Red Pulp Small B-cell Lymphoma (SDRPL): A Review of the Literature on Primary Splenic Lymphoma With Hairy Cells|url=https://pubmed.ncbi.nlm.nih.gov/29662866/|language=en|doi=10.5045/br.2018.53.1.74|pmc=PMC5898999|pmid=29662866}}</ref><ref name=":1">{{Cite journal|last=J|first=Tóth-Lipták|last2=K|first2=Piukovics|last3=Z|first3=Borbényi|last4=J|first4=Demeter|last5=E|first5=Bagdi|last6=L|first6=Krenács|date=2015|title=A Comprehensive Immunophenotypic Marker Analysis of Hairy Cell Leukemia in Paraffin-Embedded Bone Marrow Trephine Biopsies--A Tissue Microarray Study|url=https://pubmed.ncbi.nlm.nih.gov/24903677/|language=en|pmid=24903677}}</ref><ref name=":3">{{Cite journal|last=L|first=Jallades|last2=L|first2=Baseggio|last3=P|first3=Sujobert|last4=S|first4=Huet|last5=K|first5=Chabane|last6=E|first6=Callet-Bauchu|last7=A|first7=Verney|last8=S|first8=Hayette|last9=Jp|first9=Desvignes|date=2017|title=Exome Sequencing Identifies Recurrent BCOR Alterations and the Absence of KLF2, TNFAIP3 and MYD88 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/28751561/|language=en|doi=10.3324/haematol.2016.160192|pmc=PMC5622860|pmid=28751561}}</ref></blockquote>
<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":0">{{Cite journal|last=T|first=Vig|last2=Ta|first2=Kodiatte|last3=Mt|first3=Manipadam|last4=Fn|first4=Aboobacker|date=2018|title=A Rare Case of Splenic Diffuse Red Pulp Small B-cell Lymphoma (SDRPL): A Review of the Literature on Primary Splenic Lymphoma With Hairy Cells|url=https://pubmed.ncbi.nlm.nih.gov/29662866/|language=en|doi=10.5045/br.2018.53.1.74|pmc=PMC5898999|pmid=29662866}}</ref><ref name=":1">{{Cite journal|last=J|first=Tóth-Lipták|last2=K|first2=Piukovics|last3=Z|first3=Borbényi|last4=J|first4=Demeter|last5=E|first5=Bagdi|last6=L|first6=Krenács|date=2015|title=A Comprehensive Immunophenotypic Marker Analysis of Hairy Cell Leukemia in Paraffin-Embedded Bone Marrow Trephine Biopsies--A Tissue Microarray Study|url=https://pubmed.ncbi.nlm.nih.gov/24903677/|language=en|pmid=24903677}}</ref><ref name=":3">{{Cite journal|last=L|first=Jallades|last2=L|first2=Baseggio|last3=P|first3=Sujobert|last4=S|first4=Huet|last5=K|first5=Chabane|last6=E|first6=Callet-Bauchu|last7=A|first7=Verney|last8=S|first8=Hayette|last9=Jp|first9=Desvignes|date=2017|title=Exome Sequencing Identifies Recurrent BCOR Alterations and the Absence of KLF2, TNFAIP3 and MYD88 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/28751561/|language=en|doi=10.3324/haematol.2016.160192|pmc=PMC5622860|pmid=28751561}}</ref><blockquote class="blockedit">
<center><span style="color:Maroon">'''End of V4 Section'''</span>
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==Clinical Features==
==Clinical Features==


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<blockquote class='blockedit'>{{Box-round|title=v4:Clinical Features|The content below was from the old template. Please incorporate above.}}
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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":0" /><ref name=":2">{{Cite journal|last=Wy|first=Cheng|last2=Ym|first2=Zhu|last3=S|first3=Cheng|last4=Ys|first4=Chen|last5=Y|first5=Shen|date=2018|title=Development of B-cell Prolymphocytic Leukemia in a Patient With Splenic Diffuse Red Pulp Small B-cell Lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/29199492/|language=en|pmid=29199492}}</ref></blockquote>
<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":0" /><ref name=":2">{{Cite journal|last=Wy|first=Cheng|last2=Ym|first2=Zhu|last3=S|first3=Cheng|last4=Ys|first4=Chen|last5=Y|first5=Shen|date=2018|title=Development of B-cell Prolymphocytic Leukemia in a Patient With Splenic Diffuse Red Pulp Small B-cell Lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/29199492/|language=en|pmid=29199492}}</ref><blockquote class="blockedit">
<center><span style="color:Maroon">'''End of V4 Section'''</span>
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==Sites of Involvement==
==Sites of Involvement==
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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":0" /></blockquote>
<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":0" /><blockquote class="blockedit">
<center><span style="color:Maroon">'''End of V4 Section'''</span>
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==Morphologic Features==
==Morphologic Features==


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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":0" /></blockquote>
<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":0" /><blockquote class="blockedit">
<center><span style="color:Maroon">'''End of V4 Section'''</span>
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==Immunophenotype==
==Immunophenotype==


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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":0" /><ref name=":1" /><ref name=":2" /><ref>{{Cite journal|last=Y|first=Yamada|last2=M|first2=Miura|last3=M|first3=Tagari|last4=K|first4=Oshimi|last5=T|first5=Shiragata|last6=W|first6=Suga|last7=T|first7=Takahashi|last8=K|first8=Shimizu|last9=K|first9=Ohshima|date=2018|title=[Splenic Diffuse Red Pulp Small B-cell Lymphoma Diagnosed by Splenectomy Initially Mimicking Hairy Cell leukemia-Japanese Variant]|url=https://pubmed.ncbi.nlm.nih.gov/29618685/|language=en|pmid=29618685}}</ref><ref>{{Cite journal|last=G|first=Kanellis|last2=M|first2=Mollejo|last3=S|first3=Montes-Moreno|last4=Sm|first4=Rodriguez-Pinilla|last5=Jc|first5=Cigudosa|last6=P|first6=Algara|last7=C|first7=Montalban|last8=E|first8=Matutes|last9=A|first9=Wotherspoon|date=2010|title=Splenic diffuse red pulp small B-cell lymphoma: revision of a series of cases reveals characteristic clinico-pathological features|url=https://pubmed.ncbi.nlm.nih.gov/20220064/|language=en|doi=10.3324/haematol.2009.013714|pmc=PMC2895036|pmid=20220064}}</ref></blockquote>
<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":0" /><ref name=":1" /><ref name=":2" /><ref>{{Cite journal|last=Y|first=Yamada|last2=M|first2=Miura|last3=M|first3=Tagari|last4=K|first4=Oshimi|last5=T|first5=Shiragata|last6=W|first6=Suga|last7=T|first7=Takahashi|last8=K|first8=Shimizu|last9=K|first9=Ohshima|date=2018|title=[Splenic Diffuse Red Pulp Small B-cell Lymphoma Diagnosed by Splenectomy Initially Mimicking Hairy Cell leukemia-Japanese Variant]|url=https://pubmed.ncbi.nlm.nih.gov/29618685/|language=en|pmid=29618685}}</ref><ref>{{Cite journal|last=G|first=Kanellis|last2=M|first2=Mollejo|last3=S|first3=Montes-Moreno|last4=Sm|first4=Rodriguez-Pinilla|last5=Jc|first5=Cigudosa|last6=P|first6=Algara|last7=C|first7=Montalban|last8=E|first8=Matutes|last9=A|first9=Wotherspoon|date=2010|title=Splenic diffuse red pulp small B-cell lymphoma: revision of a series of cases reveals characteristic clinico-pathological features|url=https://pubmed.ncbi.nlm.nih.gov/20220064/|language=en|doi=10.3324/haematol.2009.013714|pmc=PMC2895036|pmid=20220064}}</ref><blockquote class="blockedit">
<center><span style="color:Maroon">'''End of V4 Section'''</span>
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==Chromosomal Rearrangements (Gene Fusions)==
==Chromosomal Rearrangements (Gene Fusions)==


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*No consistent gene fusion
*No consistent gene fusion


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* Individual Region Genomic Gain/Loss/LOH
* Individual Region Genomic Gain/Loss/LOH
* Characteristic Chromosomal Patterns
* Characteristic Chromosomal Patterns
* Gene Mutations (SNV/INDEL)}}
* Gene Mutations (SNV/INDEL)}}</blockquote>
{| class="wikitable"
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!Alteration
!Alteration
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==Individual Region Genomic Gain / Loss / LOH==
==Individual Region Genomic Gain / Loss / LOH==
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*In a study of 13 cases, 10q23, 14q31-q32, and 17p13 deletions in 3 cases; 9p21 deletions in 2 cases; 7q31.3-q32.3 deletion in 1 case; no trisomies 3 or 18<ref name=":4" />
*In a study of 13 cases, 10q23, 14q31-q32, and 17p13 deletions in 3 cases; 9p21 deletions in 2 cases; 7q31.3-q32.3 deletion in 1 case; no trisomies 3 or 18<ref name=":4" />
*In a study of 24 cases, 7q deletion in 6 cases; trisomy 3 and 18 in 1 case; trisomy 12 in 3 case<ref name=":3" />
*In a study of 24 cases, 7q deletion in 6 cases; trisomy 3 and 18 in 1 case; trisomy 12 in 3 case<ref name=":3" />


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==Characteristic Chromosomal Patterns==
==Characteristic Chromosomal Patterns==
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*BCOR copy number loss in 10% and often with BCOR point mutations<ref name=":3" />
*BCOR copy number loss in 10% and often with BCOR point mutations<ref name=":3" />
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*Complex karyotypes in 13%<ref name=":3" />
*Complex karyotypes in 13%<ref name=":3" />


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==Gene Mutations (SNV / INDEL)==
==Gene Mutations (SNV / INDEL)==
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{| class="wikitable sortable"
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<sup>‡</sup>Specific mutations in these genes can be found in [https://www.cbioportal.org/ cBioPortal], [https://cancer.sanger.ac.uk/cosmic COSMIC], and elsewhere<ref name=":3" />
<sup>‡</sup>Specific mutations in these genes can be found in [https://www.cbioportal.org/ cBioPortal], [https://cancer.sanger.ac.uk/cosmic COSMIC], and elsewhere<ref name=":3" />


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==Epigenomic Alterations==
==Epigenomic Alterations==
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{| class="wikitable"
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!Molecular feature
!Molecular feature
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==Genetic Diagnostic Testing Methods==
==Genetic Diagnostic Testing Methods==