HAEM5:Large B-cell lymphoma with IRF4 rearrangement: Difference between revisions

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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":1">{{Cite journal|last=de Leval|first=L.|last2=Bonnet|first2=C.|last3=Copie-Bergman|first3=C.|last4=Seidel|first4=L.|last5=Baia|first5=M.|last6=Brière|first6=J.|last7=Molina|first7=T. J.|last8=Fabiani|first8=B.|last9=Petrella|first9=T.|date=2012-12|title=Diffuse large B-cell lymphoma of Waldeyer's ring has distinct clinicopathologic features: a GELA study|url=https://pubmed.ncbi.nlm.nih.gov/22700993|journal=Annals of Oncology: Official Journal of the European Society for Medical Oncology|volume=23|issue=12|pages=3143–3151|doi=10.1093/annonc/mds150|issn=1569-8041|pmid=22700993}}</ref><ref name=":2">{{Cite journal|last=Chisholm|first=Karen M.|last2=Mohlman|first2=Jeffrey|last3=Liew|first3=Michael|last4=Termuhlen|first4=Amanda|last5=Cairo|first5=Mitchell S.|last6=Gross|first6=Thomas G.|last7=Perkins|first7=Sherrie L.|last8=Miles|first8=Rodney R.|date=2019-08|title=IRF4 translocation status in pediatric follicular and diffuse large B‐cell lymphoma patients enrolled in Children's Oncology Group trials|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/pbc.27770|journal=Pediatric Blood & Cancer|language=en|volume=66|issue=8|doi=10.1002/pbc.27770|issn=1545-5009}}</ref></blockquote>
<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":1">{{Cite journal|last=de Leval|first=L.|last2=Bonnet|first2=C.|last3=Copie-Bergman|first3=C.|last4=Seidel|first4=L.|last5=Baia|first5=M.|last6=Brière|first6=J.|last7=Molina|first7=T. J.|last8=Fabiani|first8=B.|last9=Petrella|first9=T.|date=2012-12|title=Diffuse large B-cell lymphoma of Waldeyer's ring has distinct clinicopathologic features: a GELA study|url=https://pubmed.ncbi.nlm.nih.gov/22700993|journal=Annals of Oncology: Official Journal of the European Society for Medical Oncology|volume=23|issue=12|pages=3143–3151|doi=10.1093/annonc/mds150|issn=1569-8041|pmid=22700993}}</ref><ref name=":2">{{Cite journal|last=Chisholm|first=Karen M.|last2=Mohlman|first2=Jeffrey|last3=Liew|first3=Michael|last4=Termuhlen|first4=Amanda|last5=Cairo|first5=Mitchell S.|last6=Gross|first6=Thomas G.|last7=Perkins|first7=Sherrie L.|last8=Miles|first8=Rodney R.|date=2019-08|title=IRF4 translocation status in pediatric follicular and diffuse large B‐cell lymphoma patients enrolled in Children's Oncology Group trials|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/pbc.27770|journal=Pediatric Blood & Cancer|language=en|volume=66|issue=8|doi=10.1002/pbc.27770|issn=1545-5009}}</ref><blockquote class="blockedit">
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==Clinical Features==
==Clinical Features==


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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":1" /><ref name=":2" /></blockquote>
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==Sites of Involvement==
==Sites of Involvement==
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==Morphologic Features==
==Morphologic Features==


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==Immunophenotype==
==Immunophenotype==


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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":2" /><ref>{{Cite journal|last=Sukswai|first=Narittee|last2=Lyapichev|first2=Kirill|last3=Khoury|first3=Joseph D.|last4=Medeiros|first4=L. Jeffrey|date=2020-01|title=Diffuse large B-cell lymphoma variants: an update|url=https://pubmed.ncbi.nlm.nih.gov/31735345|journal=Pathology|volume=52|issue=1|pages=53–67|doi=10.1016/j.pathol.2019.08.013|issn=1465-3931|pmid=31735345}}</ref></blockquote>
<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":2" /><ref>{{Cite journal|last=Sukswai|first=Narittee|last2=Lyapichev|first2=Kirill|last3=Khoury|first3=Joseph D.|last4=Medeiros|first4=L. Jeffrey|date=2020-01|title=Diffuse large B-cell lymphoma variants: an update|url=https://pubmed.ncbi.nlm.nih.gov/31735345|journal=Pathology|volume=52|issue=1|pages=53–67|doi=10.1016/j.pathol.2019.08.013|issn=1465-3931|pmid=31735345}}</ref><blockquote class="blockedit">
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==Chromosomal Rearrangements (Gene Fusions)==
==Chromosomal Rearrangements (Gene Fusions)==


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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":0" /><ref>{{Cite journal|last=Ramis-Zaldivar|first=Joan Enric|last2=Gonzalez-Farré|first2=Blanca|last3=Balagué|first3=Olga|last4=Celis|first4=Verónica|last5=Nadeu|first5=Ferran|last6=Salmerón-Villalobos|first6=Julia|last7=Andrés|first7=Mara|last8=Martin-Guerrero|first8=Idoia|last9=Garrido-Pontnou|first9=Marta|date=01 23, 2020|title=Distinct molecular profile of IRF4-rearranged large B-cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/31738823|journal=Blood|volume=135|issue=4|pages=274–286|doi=10.1182/blood.2019002699|issn=1528-0020|pmc=6978155|pmid=31738823}}</ref></blockquote>
<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":0" /><ref>{{Cite journal|last=Ramis-Zaldivar|first=Joan Enric|last2=Gonzalez-Farré|first2=Blanca|last3=Balagué|first3=Olga|last4=Celis|first4=Verónica|last5=Nadeu|first5=Ferran|last6=Salmerón-Villalobos|first6=Julia|last7=Andrés|first7=Mara|last8=Martin-Guerrero|first8=Idoia|last9=Garrido-Pontnou|first9=Marta|date=01 23, 2020|title=Distinct molecular profile of IRF4-rearranged large B-cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/31738823|journal=Blood|volume=135|issue=4|pages=274–286|doi=10.1182/blood.2019002699|issn=1528-0020|pmc=6978155|pmid=31738823}}</ref><blockquote class="blockedit">
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* Individual Region Genomic Gain/Loss/LOH
* Individual Region Genomic Gain/Loss/LOH
* Characteristic Chromosomal Patterns
* Characteristic Chromosomal Patterns
* Gene Mutations (SNV/INDEL)}}
* Gene Mutations (SNV/INDEL)}}</blockquote>




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==Individual Region Genomic Gain / Loss / LOH==
==Individual Region Genomic Gain / Loss / LOH==
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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref>{{Cite journal|last=Salaverria|first=Itziar|last2=Martin-Guerrero|first2=Idoia|last3=Burkhardt|first3=Birgit|last4=Kreuz|first4=Markus|last5=Zenz|first5=Thorsten|last6=Oschlies|first6=Ilske|last7=Arnold|first7=Norbert|last8=Baudis|first8=Michael|last9=Bens|first9=Susanne|date=2013-02|title=High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas|url=https://pubmed.ncbi.nlm.nih.gov/23073988|journal=Genes, Chromosomes & Cancer|volume=52|issue=2|pages=150–155|doi=10.1002/gcc.22014|issn=1098-2264|pmid=23073988}}</ref></blockquote>
<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref>{{Cite journal|last=Salaverria|first=Itziar|last2=Martin-Guerrero|first2=Idoia|last3=Burkhardt|first3=Birgit|last4=Kreuz|first4=Markus|last5=Zenz|first5=Thorsten|last6=Oschlies|first6=Ilske|last7=Arnold|first7=Norbert|last8=Baudis|first8=Michael|last9=Bens|first9=Susanne|date=2013-02|title=High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas|url=https://pubmed.ncbi.nlm.nih.gov/23073988|journal=Genes, Chromosomes & Cancer|volume=52|issue=2|pages=150–155|doi=10.1002/gcc.22014|issn=1098-2264|pmid=23073988}}</ref><blockquote class="blockedit">
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==Characteristic Chromosomal Patterns==
==Characteristic Chromosomal Patterns==
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''IRF4'' Rearrangement<ref name=":0" />
''IRF4'' Rearrangement<ref name=":0" />


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==Gene Mutations (SNV / INDEL)==
==Gene Mutations (SNV / INDEL)==
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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":3">{{Cite journal|last=Ramis-Zaldivar|first=Joan Enric|last2=Gonzalez-Farré|first2=Blanca|last3=Balagué|first3=Olga|last4=Celis|first4=Verónica|last5=Nadeu|first5=Ferran|last6=Salmerón-Villalobos|first6=Julia|last7=Andrés|first7=Mara|last8=Martin-Guerrero|first8=Idoia|last9=Garrido-Pontnou|first9=Marta|date=01 23, 2020|title=Distinct molecular profile of IRF4-rearranged large B-cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/31738823|journal=Blood|volume=135|issue=4|pages=274–286|doi=10.1182/blood.2019002699|issn=1528-0020|pmc=6978155|pmid=31738823}}</ref></blockquote>
<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref name=":3">{{Cite journal|last=Ramis-Zaldivar|first=Joan Enric|last2=Gonzalez-Farré|first2=Blanca|last3=Balagué|first3=Olga|last4=Celis|first4=Verónica|last5=Nadeu|first5=Ferran|last6=Salmerón-Villalobos|first6=Julia|last7=Andrés|first7=Mara|last8=Martin-Guerrero|first8=Idoia|last9=Garrido-Pontnou|first9=Marta|date=01 23, 2020|title=Distinct molecular profile of IRF4-rearranged large B-cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/31738823|journal=Blood|volume=135|issue=4|pages=274–286|doi=10.1182/blood.2019002699|issn=1528-0020|pmc=6978155|pmid=31738823}}</ref><blockquote class="blockedit">
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==Epigenomic Alterations==
==Epigenomic Alterations==
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==Genes and Main Pathways Involved==
==Genes and Main Pathways Involved==


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==Genetic Diagnostic Testing Methods==
==Genetic Diagnostic Testing Methods==
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<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref>{{Cite journal|last=Salaverria|first=Itziar|last2=Martin-Guerrero|first2=Idoia|last3=Burkhardt|first3=Birgit|last4=Kreuz|first4=Markus|last5=Zenz|first5=Thorsten|last6=Oschlies|first6=Ilske|last7=Arnold|first7=Norbert|last8=Baudis|first8=Michael|last9=Bens|first9=Susanne|date=2013-02|title=High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas|url=https://pubmed.ncbi.nlm.nih.gov/23073988|journal=Genes, Chromosomes & Cancer|volume=52|issue=2|pages=150–155|doi=10.1002/gcc.22014|issn=1098-2264|pmid=23073988}}</ref></blockquote>
<blockquote class='blockedit'>{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}</blockquote><ref>{{Cite journal|last=Salaverria|first=Itziar|last2=Martin-Guerrero|first2=Idoia|last3=Burkhardt|first3=Birgit|last4=Kreuz|first4=Markus|last5=Zenz|first5=Thorsten|last6=Oschlies|first6=Ilske|last7=Arnold|first7=Norbert|last8=Baudis|first8=Michael|last9=Bens|first9=Susanne|date=2013-02|title=High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas|url=https://pubmed.ncbi.nlm.nih.gov/23073988|journal=Genes, Chromosomes & Cancer|volume=52|issue=2|pages=150–155|doi=10.1002/gcc.22014|issn=1098-2264|pmid=23073988}}</ref><blockquote class="blockedit">
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==Familial Forms==
==Familial Forms==


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==Additional Information==
==Additional Information==