HAEM5:Extranodal NK/T-cell lymphoma: Difference between revisions
| [pending revision] | [pending revision] |
Teodora.Popa (talk | contribs) No edit summary |
Teodora.Popa (talk | contribs) No edit summary |
||
| Line 441: | Line 441: | ||
==Genes and Main Pathways Involved== | ==Genes and Main Pathways Involved== | ||
[https://ashpublications.org/blood/article/115/6/1226/26917/Gene-expression-profiling-identifies-emerging Huang, ''et al''] described deregulation of several signaling pathways in NK T-cell lymphoma, main ones listed below<ref name=":13" />. A review by [https://jhoonline.biomedcentral.com/articles/10.1186/s13045-019-0716-7 De Mel, ''et al''], also outlines key molecular pathways involved in the pathogenesis of ENKTL<ref>{{Cite journal|last=de Mel|first=Sanjay|last2=Hue|first2=Susan Swee-Shan|last3=Jeyasekharan|first3=Anand D.|last4=Chng|first4=Wee-Joo|last5=Ng|first5=Siok-Bian|date=2019-04-02|title=Molecular pathogenic pathways in extranodal NK/T cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/30935402|journal=Journal of Hematology & Oncology|volume=12|issue=1|pages=33|doi=10.1186/s13045-019-0716-7|issn=1756-8722|pmc=6444858|pmid=30935402}}</ref>. | [https://ashpublications.org/blood/article/115/6/1226/26917/Gene-expression-profiling-identifies-emerging Huang, ''et al''] described deregulation of several signaling pathways in NK T-cell lymphoma, main ones listed below<ref name=":13" />. A review by [https://jhoonline.biomedcentral.com/articles/10.1186/s13045-019-0716-7 De Mel, ''et al''], also outlines key molecular pathways involved in the pathogenesis of ENKTL<ref name=":15">{{Cite journal|last=de Mel|first=Sanjay|last2=Hue|first2=Susan Swee-Shan|last3=Jeyasekharan|first3=Anand D.|last4=Chng|first4=Wee-Joo|last5=Ng|first5=Siok-Bian|date=2019-04-02|title=Molecular pathogenic pathways in extranodal NK/T cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/30935402|journal=Journal of Hematology & Oncology|volume=12|issue=1|pages=33|doi=10.1186/s13045-019-0716-7|issn=1756-8722|pmc=6444858|pmid=30935402}}</ref>. | ||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
|- | |- | ||
!Gene; Genetic Alteration!!Pathway!!Pathophysiologic Outcome | !Gene; Genetic Alteration!!Pathway!!Pathophysiologic Outcome | ||
|- | |- | ||
|''JAK3'', ''STAT3'', and ''STAT5B''; Activating mutations | |''JAK3'', ''STAT3'', and ''STAT5B''; Activating mutations<ref name=":13" /><ref name=":15" /> | ||
|JAK/STAT pathway | |JAK/STAT pathway | ||
|Increased cell growth and proliferation | |Increased cell growth and proliferation | ||
|- | |- | ||
|''MYC, RUNX3'' | |''MYC, RUNX3''<ref name=":15" /> | ||
|MYC | |MYC | ||
|Increased cell proliferation and survival | |Increased cell proliferation and survival | ||
|- | |- | ||
|''AKT'' and related genes | |''AKT'' and related genes<ref name=":13" /> | ||
|AKT pathway | |AKT pathway | ||
|Increased cell growth, proliferation and survival | |Increased cell growth, proliferation and survival | ||
|- | |- | ||
|NF-κB related genes | |NF-κB related genes<ref name=":13" /><ref name=":15" /> | ||
|NF-κB pathway | |NF-κB pathway | ||
|Increased cell proliferation | |Increased cell proliferation | ||
|- | |- | ||
|''PDGFRA'' | |''PDGFRA''<ref name=":13" /><ref name=":15" /> | ||
|PDGF pathway | |PDGF pathway | ||
|Increased cell proliferation and survival | |Increased cell proliferation and survival | ||
|- | |- | ||
|''NOTCH1'' | |''NOTCH1''<ref name=":15" /> | ||
|NOTCH1 pathway | |NOTCH1 pathway | ||
|Increased cell proliferation | |Increased cell proliferation | ||
|- | |- | ||
|AURKA | |AURKA<ref name=":15" /> | ||
|Aurora kinase pathway<ref name=":12" /> | |Aurora kinase pathway<ref name=":12" /> | ||
|Increased cell proliferation and cell cycle dysregulation | |Increased cell proliferation and cell cycle dysregulation | ||