HAEM5:Myeloid/lymphoid neoplasms with other tyrosine kinase fusion genes: Difference between revisions

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 |''ETV6''
 |''ETV6::LYN'' <ref>{{Cite journal|last=Telford|first=N.|last2=Alexander|first2=S.|last3=McGinn|first3=O. J.|last4=Williams|first4=M.|last5=Wood|first5=K. M.|last6=Bloor|first6=A.|last7=Saha|first7=V.|date=2016-04-08|title=Myeloproliferative neoplasm with eosinophilia and T-lymphoblastic lymphoma with ETV6-LYN gene fusion|url=https://pubmed.ncbi.nlm.nih.gov/27058227|journal=Blood Cancer Journal|volume=6|issue=4|pages=e412|doi=10.1038/bcj.2016.11|issn=2044-5385|pmc=4855251|pmid=27058227}}</ref>
-|<span class="blue-text">EXAMPLE:</span> Typically, the last exon of ''CIC'' is fused to ''DUX4''. The fusion breakpoint in ''CIC'' is usually intra-exonic and removes an inhibitory sequence, upregulating ''PEA3'' genes downstream of ''CIC'' including ''ETV1'', ''ETV4'', and ''ETV5''.
+|Fusion between exon 5 in ''ETV6'' to exon 8 in ''LYN''.
-|<span class="blue-text">EXAMPLE:</span> t(4;19)(q25;q13)
+|Complex rearrangements involving chromosomes 8 and 12 (e.g. ins(12;8)(p13;q11q21))
-|<span class="blue-text">EXAMPLE:</span> Common (CIC-rearranged sarcoma)
+|Rare < 5%
 |<span class="blue-text">EXAMPLE:</span> D
 |
-|<span class="blue-text">EXAMPLE:</span>
+|
-''DUX4'' has many homologous genes; an alternate translocation in a minority of cases is t(10;19), but this is usually indistinguishable from t(4;19) by short-read sequencing (add references).
 |-
 |<span class="blue-text">EXAMPLE:</span> ''ALK''