Breast Cancer: Recurrent Genomic Alterations: Difference between revisions
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|20301425; 29368626; 30062102; 30504931; 33471991 | |20301425; 29368626; 30062102; 30504931; 33471991 | ||
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| | |C19MC | ||
|3 | |3 | ||
|Gain of function | |Gain of function | ||
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|TOP2A breast | |TOP2A breast | ||
|amplification, sequence variants | |amplification, sequence variants | ||
|Therapy: responsiveness to anthracycline inhibitors | |Therapy: responsiveness to anthracycline inhibitors. Prognosis: increased TOP2A expression is an adverse prognostic indicator. | ||
|22578285; 32140564; 20038724; 21917518 | |22578285; 32140564; 20038724; 21917518; 32780321; 35297009 | ||
|- | |- | ||
|''TP53'' | |''TP53'' | ||
| Line 1,431: | Line 1,431: | ||
|3 | |3 | ||
|Gain of function | |Gain of function | ||
|601622 | |[https://omim.org/entry/601622 601622] | ||
|TWIST1 | |[https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=TWIST1 TWIST1] | ||
|TWIST1 breast | |[https://www.cbioportal.org/results/oncoprint?cancer_study_list=acbc_mskcc_2015%2Cbreast_cptac_gdc%2Cbrca_hta9_htan_2022%2Cbrca_metabric%2Cbreast_msk_2025%2Cbreast_msk_2018%2Cbrca_pareja_msk_2020%2Cbrca_mskcc_2019%2Cbreast_alpelisib_2020%2Cbrca_smc_2018%2Cbrca_bccrc_xenograft_2014%2Cbfn_duke_nus_2015%2Cbrca_bccrc%2Cbrca_broad%2Cbrca_sanger%2Cbrca_tcga_pub2015%2Cbrca_tcga%2Cbrca_tcga_pub%2Cbrca_tcga_pan_can_atlas_2018%2Cbrca_tcga_gdc%2Cbrca_jup_msk_2020%2Cbrca_mapk_hp_msk_2021%2Cmbc_msk_2021%2Cbrca_aurora_2023%2Cbrca_dfci_2020%2Cbrca_igr_2015%2Cbreast_ink4_msk_2021%2Cilc_msk_2023%2Cbrca_cptac_2020%2Cbrca_mbcproject_wagle_2017%2Cbrca_mbcproject_2022%2Cbrca_fuscc_2020&Z_SCORE_THRESHOLD=2.0&RPPA_SCORE_THRESHOLD=2.0&profileFilter=mutations%2Cstructural_variants%2Ccna%2Cgistic%2Clog2CNA&case_set_id=all&gene_list=TWIST1&geneset_list=%20&tab_index=tab_visualize&Action=Submit TWIST1 breast] | ||
|amplification, altered expression | |amplification, altered expression | ||
|Diseases: breast cancer invasion and metastasis, basal-like breast cancer | |Diseases: breast cancer invasion and metastasis, basal-like breast cancer | ||
|17437280; 19373776; 15131050; 27412325; 29073077; 27524420; 38963044; 35843065; 38003483 | |[https://pubmed.ncbi.nlm.nih.gov/17437280/ 17437280]; [https://pubmed.ncbi.nlm.nih.gov/19373776/ 19373776]; [https://pubmed.ncbi.nlm.nih.gov/15131050/ 15131050]; [https://pubmed.ncbi.nlm.nih.gov/27412325/ 27412325]; [https://pubmed.ncbi.nlm.nih.gov/29073077/ 29073077]; [https://pubmed.ncbi.nlm.nih.gov/27524420/ 27524420]; [https://pubmed.ncbi.nlm.nih.gov/38963044/ 38963044]; [https://pubmed.ncbi.nlm.nih.gov/35843065/ 35843065]; [https://pubmed.ncbi.nlm.nih.gov/38003483/ 38003483] | ||
|- | |- | ||
|''ZNF217'' | |''ZNF217'' | ||