HAEM5:Adult T-cell leukaemia/lymphoma: Difference between revisions
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|In-frame fusion converts inhibitory CTLA4/ICOS extracellular domains into CD28 signaling tail → constitutive co-stimulation | |In-frame fusion converts inhibitory CTLA4/ICOS extracellular domains into CD28 signaling tail → constitutive co-stimulation | ||
|Rearrangements within '''2q33''' region (CTLA4/ICOS/CD28 are clustered); interstitial events/inversions | |Rearrangements within '''2q33''' region (CTLA4/ICOS/CD28 are clustered); interstitial events/inversions | ||
|Rare, but enriched in younger patients | |Rare, but enriched in younger patients (3/8 cases, 37.5%<ref>{{Cite journal|last=Yoshida|first=Noriaki|last2=Shigemori|first2=Kay|last3=Donaldson|first3=Nicholas|last4=Trevisani|first4=Christopher|last5=Cordero|first5=Nicolas A.|last6=Stevenson|first6=Kristen E.|last7=Bu|first7=Xia|last8=Arakawa|first8=Fumiko|last9=Takeuchi|first9=Mai|date=2020-04-23|title=Genomic landscape of young ATLL patients identifies frequent targetable CD28 fusions|url=https://pubmed.ncbi.nlm.nih.gov/31961925|journal=Blood|volume=135|issue=17|pages=1467–1471|doi=10.1182/blood.2019001815|issn=1528-0020|pmc=7180081|pmid=31961925}}</ref>) | ||
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|Potential for CTLA4 blockade as treatment when CD28 fusions are present | |||
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