HAEM5:Adult T-cell leukaemia/lymphoma: Difference between revisions
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|1q gains common in lymphoma-type ATLL | |1q gains common in lymphoma-type ATLL | ||
|- | |- | ||
|2 | |||
|Gain | |||
|2p | |||
|''BCL11A, REL'' | |||
| | | | ||
|No | |||
| | | | ||
|- | |||
|3 | |||
|Gain | |||
|3p | |||
| | | | ||
| | |||
|No | |||
| | |||
|- | |||
|4 | |||
|Gain | |||
|4q | |||
| | |||
| | |||
|No | |||
| | |||
|- | |||
|6 | |||
|Loss | |||
|6q | |||
| | |||
| | |||
|No | |||
| | |||
|- | |||
|7 | |||
|Gain | |||
|7p, 7q | |||
| | |||
| | |||
|No | |||
| | |||
|- | |||
|9 | |||
|Loss/homozygous deletion | |||
|9p21.3 | |||
|''CDKN2A/B'' | |||
|P | |||
|No | |||
|More common in aggressive (acute/lymphoma) subtypes | |||
|- | |||
|9 | |||
|Amp | |||
|9p24.1; chr9:5,450,542–5,470,554 [GRCh38; ~20 kb] | |||
|''PD-L1'' (''CD274'') | |||
|P | |||
|No | |||
|9p24.1 amplifications of ''PD-L1'' predict worse prognosis in both indolent and aggressive ATLL; more common in aggressive (acute/lymphoma) subtypes; included in multivariate risk model | |||
|- | |||
|10 | |||
|Loss | |||
|10p | |||
| | |||
| | |||
|No | |||
| | |||
|- | |||
|13 | |||
|Loss | |||
|13q32 | |||
|''GPR183'' | |||
| | |||
|No | |||
|More frequent in older patients | |||
|- | |||
|14 | |||
|Gain | |||
|14q | |||
| | |||
| | |||
|No | |||
| | |||
|- | |||
|16 | |||
|Loss | |||
|16q23 | |||
|''WWOX'' | |||
| | |||
|No | |||
| | |||
|- | |||
|18 | |||
|Loss | |||
|18p | |||
| | | | ||
| | | | ||