Compendium of Cancer Genome Aberrations

HAEM5:B-lymphoblastic leukaemia/lymphoma with high hyperdiploidy: Difference between revisions

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|Gain
|Gain
|Chr21
|Chr21
|<span class="blue-text">EXAMPLE:</span>
|''RUNX1''
Unknown
|<span class="blue-text">EXAMPLE:</span> D, P
|<span class="blue-text">EXAMPLE:</span> D, P
|<span class="blue-text">EXAMPLE:</span> No
|<span class="blue-text">EXAMPLE:</span> No
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Presence of monosomy 7 (or 7q deletion) is sufficient for a diagnosis of AML with MDS-related changes when there is ≥20% blasts and no prior therapy (add reference).  Monosomy 7/7q deletion is associated with a poor prognosis in AML (add references).
Presence of monosomy 7 (or 7q deletion) is sufficient for a diagnosis of AML with MDS-related changes when there is ≥20% blasts and no prior therapy (add reference).  Monosomy 7/7q deletion is associated with a poor prognosis in AML (add references).
|-
|-
|<span class="blue-text">EXAMPLE:</span>
|X
8
|Gain
|<span class="blue-text">EXAMPLE:</span> Gain
|ChrX
|<span class="blue-text">EXAMPLE:</span>
chr8
|<span class="blue-text">EXAMPLE:</span>
|<span class="blue-text">EXAMPLE:</span>
Unknown
Unknown
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Common recurrent secondary finding for t(8;21) (add references).
Common recurrent secondary finding for t(8;21) (add references).
|-
|-
|<span class="blue-text">EXAMPLE:</span>
|6
17
|Gain
|<span class="blue-text">EXAMPLE:</span> Amp
|Chr6
|<span class="blue-text">EXAMPLE:</span>
17q12; chr17:39,700,064-39,728,658 [hg38; 28.6 kb]
|<span class="blue-text">EXAMPLE:</span>
|<span class="blue-text">EXAMPLE:</span>
''ERBB2''
''ERBB2''
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Amplification of ''ERBB2'' is associated with HER2 overexpression in HER2 positive breast cancer (add references). Add criteria for how amplification is defined.
Amplification of ''ERBB2'' is associated with HER2 overexpression in HER2 positive breast cancer (add references). Add criteria for how amplification is defined.
|-
|-
|14
|Gain
|Chr14
|
|
|
|
|-
|18
|Gain
|Chr18
|
|
|Prognostic significance: has been correlated with a lower risk of relapse
|
|
|
|
|-
|4
|Gain
|Chr4
|
|
|
|
|-
|17
|Gain
|Chr17
|
|
|
|
|-
|10
|Gain
|Chr10
|
|
|
|
|-
|8
|Gain
|Chr8
|
|
|
|
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