HAEM5:T-prolymphocytic leukaemia: Difference between revisions
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|inv(14)(q11q32) | |inv(14)(q11q32) | ||
t(14;14)(q11.2;q32.1) | t(14;14)(q11.2;q32.1) | ||
| | |''TCL1A'' or ''MTCP1'' activation with constitutive activation of the ''AKT'' signaling pathway, promoting proliferation and survival | ||
|Common | |Common | ||
|D | |D | ||
|No | |No | ||
|Major diagnostic criteria <ref name=":6" /> | |Major diagnostic criteria <ref name=":6" /> | ||
|- | |||
|ATM loss / mutation; del(11)(q22–q23), loss of heterozygosity, or biallelic mutation | |||
|Impaired DNA damage response → genomic instability, accumulation of secondary lesions | |||
|Common | |||
|D,P | |||
| | |||
| | |||
|}<br /> | |}<br /> | ||
==Gene Mutations (SNV/INDEL)== | ==Gene Mutations (SNV/INDEL)== | ||