HAEM5:B-lymphoblastic leukaemia/lymphoma with BCR::ABL1-like features: Difference between revisions
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|'''Comment''' | |'''Comment''' | ||
|- | |- | ||
| rowspan="12" | | | rowspan="12" |''[[ABL1]]'' | ||
(9q34) | (9q34) | ||
|''CENPC1'' | |''CENPC1'' | ||
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| | | | ||
|- | |- | ||
| rowspan="3" | | | rowspan="3" |''[[ABL2]]'' | ||
(1q25.2) | (1q25.2) | ||
|''PAG1'' | |''PAG1'' | ||
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| | | | ||
|- | |- | ||
| rowspan="2" | | | rowspan="2" |''[[CRLF2]]'' | ||
(Xp22.3 & Yp11.3) | (Xp22.3 & Yp11.3) | ||
|''[[IGH]]'' | |''[[IGH]]'' | ||
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| | | | ||
|- | |- | ||
| rowspan="3" | | | rowspan="3" |''CSF1R'' | ||
(5q32) | (5q32) | ||
|''MEF2D'' | |''MEF2D'' | ||
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| | | | ||
|- | |- | ||
| | |''DGKH'' (13q14.1) | ||
|''ZFAND3'' | |''ZFAND3'' | ||
|t(6;13)(p21.2;q14.1) | |t(6;13)(p21.2;q14.1) | ||
| Line 221: | Line 221: | ||
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms | |Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms | ||
|- | |- | ||
| rowspan="4" | | | rowspan="4" |''EPOR'' (19p13.2) | ||
|''[[IGH]]'' | |''[[IGH]]'' | ||
|ins(14;19)(q32;p13.2p13.2) | |ins(14;19)(q32;p13.2p13.2) | ||
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|- | |- | ||
| | |''IL2RB'' (22q12.3) | ||
|''MYH9'' | |''MYH9'' | ||
|22q12.3 rearrangement | |22q12.3 rearrangement | ||
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|On the same chromosome arm; however, a simple deletion cannot cause the fusion due to the orientation of genes | |On the same chromosome arm; however, a simple deletion cannot cause the fusion due to the orientation of genes | ||
|- | |- | ||
| rowspan="22" | | | rowspan="22" |''[[JAK2]]'' | ||
(9p24.1) | (9p24.1) | ||
|''ATF7IP'' | |''ATF7IP'' | ||
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| | | | ||
|- | |- | ||
| | |''[[PDGFRA]]'' | ||
(4q12) | (4q12) | ||
|''FIP1L1'' | |''FIP1L1'' | ||
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|Interstitial deletion. Seen also in myeloid/lymphoid neoplasms with eosinophilia | |Interstitial deletion. Seen also in myeloid/lymphoid neoplasms with eosinophilia | ||
|- | |- | ||
| rowspan="8" | | | rowspan="8" |''[[PDGFRB]]'' (5q32) | ||
|''ATF7IP'' | |''ATF7IP'' | ||
|t(5;12)(q32;p13.1) | |t(5;12)(q32;p13.1) | ||
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| | | | ||
|- | |- | ||
| rowspan="3" | | | rowspan="3" |''PTK2B'' (8p21.2) | ||
|''[[KDM6A]]'' | |''[[KDM6A]]'' | ||
|t(X;8)(p11.3;p21.2) | |t(X;8)(p11.3;p21.2) | ||
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|- | |- | ||
| rowspan="3" | | | rowspan="3" |''TYK2'' (19p13.2) | ||
|''MYB'' | |''MYB'' | ||
|t(6;19)(q23.3;p13.2) | |t(6;19)(q23.3;p13.2) | ||