Compendium of Cancer Genome Aberrations

CNS5:Pleomorphic xanthoastrocytoma: Difference between revisions

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|Promoter mutation
|Promoter mutation
|Other  
|Other  
|<span class="blue-text">EXAMPLE:</span> Common (breast cancer)
|Recurrent
|<span class="blue-text">EXAMPLE:</span> P
|P
|
|Yes (WHO CNS5)
|<span class="blue-text">EXAMPLE:</span> >90% are somatic; rare germline alterations associated with Li-Fraumeni syndrome (add reference). Denotes a poor prognosis in breast cancer.
|Associated with anaplastic progression, poor recurrence-free survival, and adverse prognosis in high-grade PXA.
|-
|-
|<span class="blue-text">EXAMPLE:</span> ''BRAF''; Activating mutations
|IDH1/IDH2
|<span class="blue-text">EXAMPLE:</span> Activating mutations
|Missense (R132H, etc)
|<span class="blue-text">EXAMPLE:</span> Oncogene
|<span class="blue-text">EXAMPLE:</span> Oncogene
|<span class="blue-text">EXAMPLE:</span> Common (melanoma)
|<span class="blue-text">EXAMPLE:</span> Common (melanoma)
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