HAEM5:Kikuchi-Fujimoto disease: Difference between revisions - Compendium of Cancer Genome Aberrations

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==Genes and Main Pathways Involved==

<big>Kikuchi-Fujimoto disease does '''not have characteristic or recurrent genetic alterations'''.</big>

<big>However, in a study using exome and transcriptome sequencing of lymph node tissue samples from KFD patients, fourteen '''single nucleotide polymorphisms''' were identified as candidate markers for the disease and found hundreds of genes with altered expression involving immune system, chromatin remodeling, transcription pathways.</big>

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==Additional Information==

<big>Most published studies indicate a '''reactive, immune-mediated process''' rather than a neoplastic one. Some reports describe '''HLA class II associations''' (e.g., HLA-DPA1 and HLA-DPB1 polymorphisms)</big><ref>{{Cite journal|last=Tanaka|first=T.|last2=Ohmori|first2=M.|last3=Yasunaga|first3=S.|last4=Ohshima|first4=K.|last5=Kikuchi|first5=M.|last6=Sasazuki|first6=T.|date=1999-09|title=DNA typing of HLA class II genes (HLA‐DR, ‐DQ and ‐DP) in Japanese patients with histiocytic necrotizing lymphadenitis (Kikuchi’s disease)|url=https://onlinelibrary.wiley.com/doi/10.1034/j.1399-0039.1999.540305.x|journal=Tissue Antigens|language=en|volume=54|issue=3|pages=246–253|doi=10.1034/j.1399-0039.1999.540305.x|issn=0001-2815}}</ref> <big>in certain populations</big><big>, suggesting a genetic susceptibility.</big><ref>{{Cite journal|last=Isoda|first=Atsushi|last2=Tahara|first2=Kenichi|last3=Ide|first3=Munenori|date=2023-12|title=Kikuchi-Fujimoto Disease in Human Leukocyte Antigen Partially Matched Siblings: A Case Study of Familial Susceptibility|url=https://pubmed.ncbi.nlm.nih.gov/38264372|journal=Cureus|volume=15|issue=12|pages=e51010|doi=10.7759/cureus.51010|issn=2168-8184|pmc=10803893|pmid=38264372}}</ref>

Exomes and transcriptomes of lymph node tissue samples from KFD patients were analyzed by DNA sequencing. Fourteen single nucleotide polymorphisms (SNPs) were identified as candidate KFD markers and found hundreds of genes with altered expression (238 up, 1,519 down) involving immune system, chromatin remodeling, transcription pathways.

==Links==

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 NA
 ==Genes and Main Pathways Involved==
 <big>Kikuchi-Fujimoto disease does '''not have characteristic or recurrent genetic alterations'''.</big>
+<big>However, in a study using exome and transcriptome sequencing of lymph node tissue samples from KFD patients, fourteen '''single nucleotide polymorphisms''' were identified as candidate markers for the disease and found hundreds of genes with altered expression involving immune system, chromatin remodeling, transcription pathways.</big>
 {| class="wikitable sortable"
 |-
@@ Line 130: / Line 132: @@
 ==Additional Information==
 <big>Most published studies indicate a '''reactive, immune-mediated process''' rather than a neoplastic one. Some reports describe '''HLA class II associations''' (e.g., HLA-DPA1 and HLA-DPB1 polymorphisms)</big><ref>{{Cite journal|last=Tanaka|first=T.|last2=Ohmori|first2=M.|last3=Yasunaga|first3=S.|last4=Ohshima|first4=K.|last5=Kikuchi|first5=M.|last6=Sasazuki|first6=T.|date=1999-09|title=DNA typing of HLA class II genes (HLA‐DR, ‐DQ and ‐DP) in Japanese patients with histiocytic necrotizing lymphadenitis (Kikuchi’s disease)|url=https://onlinelibrary.wiley.com/doi/10.1034/j.1399-0039.1999.540305.x|journal=Tissue Antigens|language=en|volume=54|issue=3|pages=246–253|doi=10.1034/j.1399-0039.1999.540305.x|issn=0001-2815}}</ref> <big>in certain populations</big><big>, suggesting a genetic susceptibility.</big><ref>{{Cite journal|last=Isoda|first=Atsushi|last2=Tahara|first2=Kenichi|last3=Ide|first3=Munenori|date=2023-12|title=Kikuchi-Fujimoto Disease in Human Leukocyte Antigen Partially Matched Siblings: A Case Study of Familial Susceptibility|url=https://pubmed.ncbi.nlm.nih.gov/38264372|journal=Cureus|volume=15|issue=12|pages=e51010|doi=10.7759/cureus.51010|issn=2168-8184|pmc=10803893|pmid=38264372}}</ref>
+Exomes and transcriptomes of lymph node tissue samples from KFD patients were analyzed by DNA sequencing. Fourteen single nucleotide polymorphisms (SNPs) were identified as candidate KFD markers and found hundreds of genes with altered expression (238 up, 1,519 down) involving immune system, chromatin remodeling, transcription pathways.
 ==Links==