HAEM5:Systemic EBV-positive T-cell lymphoma of childhood: Difference between revisions

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 == Genetic Diagnostic Testing Methods ==
+WHO 5th edition ''essential'' diagnostic criteria include:<ref name=":3" /><ref name=":6" />
-* WHO 5th edition ''essential'' diagnostic criteria include:<ref name=":3" /><ref name=":6" />
+Acute presentation with fever and systemic symptoms
-** Acute presentation with fever and systemic symptoms
-** Multiorgan infiltration by atypical T-cells
-** EBV-positivity exclusion of known immunodeficiency
-* WHO 5th edition ''desirable'' diagnostic criteria include:<ref name=":3" /><ref name=":6" />
+Multiorgan infiltration by atypical T-cells
-** Clonal TCR-gene rearrangement
-** Hemophagocytic lymphohistiocytosis (HLH)
-** Hepatosplenomegaly
-* TCR-gene rearrangements can be detected via PCR or NGS methods. Of note, T-cell clonality can also be detected in EBV-associated HLH and other EBV-associated disorders.<ref name=":10" />
+EBV-positivity exclusion of known immunodeficiency
+WHO 5th edition ''desirable'' diagnostic criteria include:<ref name=":3" /><ref name=":6" />
+Clonal TCR-gene rearrangement
+Hemophagocytic lymphohistiocytosis (HLH)
+Hepatosplenomegaly
+TCR-gene rearrangements can be detected via PCR or NGS methods. Of note, T-cell clonality can also be detected in EBV-associated HLH and other EBV-associated disorders.<ref name=":10" /><center>
 == Familial Forms ==
 Racial predisposition suggests a genetic background; however, no specific genetic abnormalities have been detected