HAEM5:B-lymphoblastic leukaemia/lymphoma with hypodiploidy: Difference between revisions
| [pending revision] | [pending revision] |
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|RTK or Ras signaling | |RTK or Ras signaling | ||
|Constitutive activation of mitogenic and anti-apoptotic pathways, driving uncontrolled cell proliferation, survival, and malignant transformation. | |Constitutive activation of mitogenic and anti-apoptotic pathways, driving uncontrolled cell proliferation, survival, and malignant transformation. | ||
|- | |||
|''CDKN2A/B, TP53, RB1''; Loss of function mutations | |||
|Cell cycle and apoptosis | |||
|Propagation of genetically altered cells. | |||
|- | |- | ||
|''IKZF1, IKZF2, IKZF3, PAX5, EBF1, VPREB1'' | |''IKZF1, IKZF2, IKZF3, PAX5, EBF1, VPREB1'' | ||
|B-cell development | |B-cell development | ||
| | | | ||
|- | |- | ||
|''ETV6'' | |''ETV6'' | ||
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|} | |} | ||
<blockquote class="blockedit"> | <blockquote class="blockedit"><center> | ||
<center> | |||
---- | ---- | ||
</blockquote> | </blockquote> | ||