HAEM5:EBV-positive diffuse large B-cell lymphoma: Difference between revisions
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|Loss of function aberration in the SH2 domain<ref name=":1" /> | |Loss of function aberration in the SH2 domain<ref name=":1" /> | ||
|Tumor Suppressor gene<ref>{{Cite journal|last=Liau|first=Nicholas P. D.|last2=Laktyushin|first2=Artem|last3=Lucet|first3=Isabelle S.|last4=Murphy|first4=James M.|last5=Yao|first5=Shenggen|last6=Whitlock|first6=Eden|last7=Callaghan|first7=Kimberley|last8=Nicola|first8=Nicos A.|last9=Kershaw|first9=Nadia J.|date=2018-04-19|title=The molecular basis of JAK/STAT inhibition by SOCS1|url=https://www.nature.com/articles/s41467-018-04013-1|journal=Nature Communications|language=en|volume=9|issue=1|pages=1558|doi=10.1038/s41467-018-04013-1|issn=2041-1723|pmc=5908791|pmid=29674694}}</ref> | |Tumor Suppressor gene<ref name=":7">{{Cite journal|last=Liau|first=Nicholas P. D.|last2=Laktyushin|first2=Artem|last3=Lucet|first3=Isabelle S.|last4=Murphy|first4=James M.|last5=Yao|first5=Shenggen|last6=Whitlock|first6=Eden|last7=Callaghan|first7=Kimberley|last8=Nicola|first8=Nicos A.|last9=Kershaw|first9=Nadia J.|date=2018-04-19|title=The molecular basis of JAK/STAT inhibition by SOCS1|url=https://www.nature.com/articles/s41467-018-04013-1|journal=Nature Communications|language=en|volume=9|issue=1|pages=1558|doi=10.1038/s41467-018-04013-1|issn=2041-1723|pmc=5908791|pmid=29674694}}</ref> | ||
|Common<ref name=":1" /><ref name=":2" /><ref name=":3" /> | |Common<ref name=":1" /><ref name=":2" /><ref name=":3" /> | ||
|P, T | |P, T | ||
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|''SOCS1;'' Activating mutations | |''SOCS1;'' Activating mutations | ||
|JAK-STAT and interferon gamma (INFγ) signaling pathways | |JAK-STAT and interferon gamma (INFγ) signaling pathways | ||
|< | |Negative regulator of the JAK-STAT INFγ signaling pathways<ref name=":1" /><ref name=":7" /> | ||
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|<span class="blue-text">EXAMPLE:</span> ''CDKN2A''; Inactivating mutations | |<span class="blue-text">EXAMPLE:</span> ''CDKN2A''; Inactivating mutations | ||