Plasma Cell Neoplasms Tables: Recurrent Cytogenomic Alterations: Difference between revisions
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|'''Significance (Recurrent, Diagnostic, Prognostic, Targeted treatment)''' | |'''Significance (Recurrent, Diagnostic, Prognostic, Targeted treatment)''' | ||
|'''Strength of Evidence (Level 1, 2, 3, see legend below table for criteria)''' | |'''Strength of Evidence (Level 1, 2, 3, see legend below table for criteria)''' | ||
|'''References''' | |'''References''' | ||
|- | |- | ||
| rowspan="9" |1 | | rowspan="9" |1 | ||
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|1p13.2 | |1p13.2 | ||
|Loss | |Loss | ||
| | |''[[MAGI3]]'', BCL2 like and others | ||
|Recurrent | |Recurrent | ||
|3 | |3 | ||
| Line 120: | Line 120: | ||
|4q35.1 | |4q35.1 | ||
|Loss | |Loss | ||
|''[[DCTD]], [[ING2]] | |''[[DCTD]], [[ING2]]'' and others | ||
|Recurrent | |Recurrent | ||
|2 | |2 | ||
| Line 149: | Line 149: | ||
|5p14.3 | |5p14.3 | ||
|Gain | |Gain | ||
|''CDH12 | |''[[CDH10]], [[CDH12]]'' | ||
|Recurrent | |Recurrent | ||
|3 | |3 | ||
| Line 163: | Line 163: | ||
|5q13.2 | |5q13.2 | ||
|Loss | |Loss | ||
|''[[OCLN]], [[NAIP]]'' | |''[[OCLN]], [[NAIP]]'' and others | ||
|Recurrent | |Recurrent | ||
|2 | |2 | ||
|<ref name=":3" /> | |<ref name=":3" /> | ||
|- | |- | ||
| rowspan=" | | rowspan="6" |6 | ||
|6p | |6p | ||
|Gain | |Gain | ||
| Line 210: | Line 210: | ||
|3 | |3 | ||
|<ref name=":5" /> | |<ref name=":5" /> | ||
|- | |- | ||
| rowspan="4" |7 | | rowspan="4" |7 | ||
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|7p15.2 | |7p15.2 | ||
|Gain | |Gain | ||
|''[[CBX3]], etc | |''[[CBX3]]'', etc | ||
|Recurrent | |Recurrent | ||
|3 | |3 | ||
| Line 267: | Line 260: | ||
|Recurrent | |Recurrent | ||
|3 | |3 | ||
|<ref name=":5" /> | |<ref name=":5" /> | ||
|- | |- | ||
|8q | |8q | ||
| Line 285: | Line 278: | ||
|8q24.3 | |8q24.3 | ||
|Gain | |Gain | ||
|''[[MAPK15]], [[TOP1MT]], [[CYP11B11]] (P450), ZNF41, | |''[[MAPK15]], [[TOP1MT]], [[CYP11B11]] (P450), [[ZNF41]], [[ZNF517]], [[ZNF616]]'' and ''[[ZNF707]]'' | ||
|Recurrent | |Recurrent | ||
|3 | |3 | ||
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|11q13.1/q13.4 | |11q13.1/q13.4 | ||
|Gain | |Gain | ||
|''[[SCYL1]], [[MAP3K11]], [[CCND1]], [[FGF4]], [[FGF3]], [[NUMA]] | |''[[SCYL1]], [[MAP3K11]], [[CCND1]], [[FGF4]], [[FGF3]], [[NUMA]]'' and ''[[RELT]]'' | ||
|Recurrent | |Recurrent | ||
|3 | |3 | ||
| Line 576: | Line 569: | ||
|19p/ 19p13 | |19p/ 19p13 | ||
|Gain | |Gain | ||
|''ICAM4,ICAM4, [[IBCL2L12]], [[TYK2]], [[IL2]] | |''ICAM4, ICAM4, [[IBCL2L12]], [[TYK2]], [[IL2]]'' and ''[[DNMT1]]'' | ||
|Recurrent | |Recurrent | ||
|3 | |3 | ||
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| rowspan="8" |X | | rowspan="8" |X | ||
|X | |X | ||
|Gain/ Loss | |Gain / Loss | ||
| | | | ||
|Recurrent | |Recurrent | ||
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|Genome wide load of CNA > 100Mb | |Genome wide load of CNA > 100Mb | ||
| | | | ||
| | |Gain / Loss | ||
| | | | ||
|associated with significant change in GEP at relapse | |associated with significant change in GEP at relapse | ||