Recurrent Genomic Alterations in Pediatric and Adult Central Nervous System Tumors Detected by Chromosomal Microarray: Difference between revisions
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==Recurrent Genomic Alterations in Pediatric and Adult CNS Detected by Chromosomal Microarray | ==Recurrent Genomic Alterations in Pediatric and Adult CNS Detected by Chromosomal Microarray | ||
Table 1 - Pediatric Central Nervous System Tumors. Table derived from | Table 1 - Pediatric Central Nervous System Tumors. Table derived from CGC CNS Workgroup 2018. | ||
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| Generally indolent tumors for which surgical resection can be curative | | Generally indolent tumors for which surgical resection can be curative | ||
| PMID:25461780; PMID:23583981; PMID:11996800 PMID:23609006; PMID:29880043 | | PMID:25461780; PMID:23583981; PMID:11996800 PMID:23609006; PMID:29880043 | ||
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|Low grade glioma, WHO grade II | |||
|Diffuse astrocytoma | |||
|No diagnostic aberrations | |||
| '''Rearrangement:''' MYBL1 truncating rearrangements and tandem duplication, FGFR1 rearrangements; '''Mutation:''' FGFR1 | |||
| Anaplastic features associated with decreased progression free survival | |||
| PMID:25664944; PMID:23633565; PMID:26061751 PMID:26824661; PMID:26004297; PMID:25461780 PMID:23583981 | |||
|- | |- | ||
| | | | ||
| Pleomorphic xanthoastrocytoma (PXA) | |||
| Polysomy 3, polysomy 7 observed; '''Loss:''' monosomy 9 / 9p deletion | |||
| '''Mutations:''' BRAF V600E in ~60%; TP53 (5%); '''Loss:''' CDKN2A/CDKN2B | |||
| | |||
| PMID:25461780; PMID:23583981; PMID:16909113; PMID:12484572 | |||
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