CNS5:Diffuse hemispheric glioma, H3 G34-mutant: Difference between revisions
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==Cancer Category/Type== | ==Cancer Category/Type== | ||
Gliomas, glioneuronal tumours, and neuronal tumours / Paediatric-type diffuse high-grade gliomas | |||
==Cancer Sub-Classification / Subtype== | ==Cancer Sub-Classification / Subtype== | ||
Diffuse hemispheric glioma, H3 G34–mutant | |||
==Definition / Description of Disease== | ==Definition / Description of Disease== | ||
Diffuse hemispheric glioma, H3 G34–mutant is characterized by point mutations in the ''H3-3A'' gene encoding for histone H3 protein. Point mutations are clustered at codon 34 including c.103G>A p.G35R (G34R), c.103G>C p.G35R (G34R), or c.104G>T p.G35V (G34V). The distinct tumor entity is featured with aggressive glioma that arises from cerebral hemispheres and DHG is included in WHO 5th edition as CNS grade 4 tumor type. | |||
==Synonyms / Terminology== | ==Synonyms / Terminology== | ||
Paediatric glioblastoma, H3.3 G34–mutant (not recommended) | |||
==Epidemiology / Prevalence== | ==Epidemiology / Prevalence== | ||