BRST5:Secretory carcinoma: Difference between revisions
| [unchecked revision] | [unchecked revision] |
| Line 8: | Line 8: | ||
==Cancer Category/Type== | ==Cancer Category/Type== | ||
Breast | |||
==Cancer Sub-Classification / Subtype== | ==Cancer Sub-Classification / Subtype== | ||
Secretory Carcinoma of Breast | |||
==Definition / Description of Disease== | ==Definition / Description of Disease== | ||
Secretory carcinoma is a low-grade tumor displaying pushing borders and areas of unequivocal stromal invasion. Tumors may show combinations of microcystic, solid and tubular patterns. The microcystic pattern is composed of irregular shaped small cysts lined with single layer of tumor cells and filled with eosinophilic secretions. The tubular pattern shows luminal eosinophil secretions. The microcystic and tubular patterns can mimic thyroid follicles and can merge into solid islands. Tumor cells are polygonal with granular eosinophilic to foamy cytoplasm. Tumor nuclei are slightly enlarged and regular in shape with inconspicuous nucleoli. Mitotic activity is rare. | |||
==Synonyms / Terminology== | ==Synonyms / Terminology== | ||
Synonyms: Juvenile breast carcinoma (historical) | |||
==Epidemiology / Prevalence== | ==Epidemiology / Prevalence== | ||
Secretory carcinomas account for less than 0.05% of all breast cancers. It has been reported in both genders, but predominantly in women. | |||
==Clinical Features== | ==Clinical Features== | ||
| Line 31: | Line 31: | ||
{| class="wikitable" | {| class="wikitable" | ||
|'''Signs and Symptoms''' | |'''Signs and Symptoms''' | ||
| | |Well-circumscribed mobile masses | ||
|- | |- | ||
|'''Laboratory Findings''' | |'''Laboratory Findings''' | ||
| | |NA | ||
|} | |} | ||
==Sites of Involvement== | ==Sites of Involvement== | ||
The tumors are commonly seen in sub-areolar area. | |||
==Morphologic Features== | ==Morphologic Features== | ||
Microcystic, solid and tubular patterns | |||
==Immunophenotype== | ==Immunophenotype== | ||
| Line 61: | Line 53: | ||
!Finding!!Marker | !Finding!!Marker | ||
|- | |- | ||
|Positive (universal)|| | |Positive (universal)||S100, EMA | ||
|- | |- | ||
|Positive (subset)|| | |Positive (subset)|| | ||
|- | |- | ||
|Negative (universal)|| | |Negative (universal)||ER, PR, and HER2 | ||
|- | |- | ||
|Negative (subset)|| | |Negative (subset)|| | ||
|} | |} | ||
| Line 82: | Line 74: | ||
!Notes | !Notes | ||
|- | |- | ||
| | |t(12;15)(p13;q25)||5’ETV6::3’NTRK3||EXAMPLE der(22)||92% (PMID: 12450792) | ||
|Yes | |||
|Yes | |Yes | ||
|Yes | |Yes | ||
|EXAMPLE | |EXAMPLE | ||
| Line 218: | Line 209: | ||
==Genetic Diagnostic Testing Methods== | ==Genetic Diagnostic Testing Methods== | ||
FISH, RT-PCR, RNAseq | |||
==Familial Forms== | ==Familial Forms== | ||