Compendium of Cancer Genome Aberrations

CNS5:Diffuse hemispheric glioma, H3 G34-mutant: Difference between revisions

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==NPrimary Author(s)*==
==Primary Author(s)*==


Xiaolin Hu, PhD, Sema4 OpCo Inc.
Xiaolin Hu, PhD, Sema4 OpCo Inc.
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==Gene Mutations (SNV/INDEL/Methylation)==
==Gene Mutations (SNV/INDEL/Methylation)==


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{| class="wikitable sortable"
{| class="wikitable sortable"
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!Notes
!Notes
|-
|-
|H3F3A p.G35R/V
|''H3-3A'' p.G35R/V
|chromosome modification
|chromosome modification
|p.G35R 94%
|p.G35R 94%
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|
|
|-
|-
|MGMT
|''MGMT''
|promoter methylation
|promoter methylation
|70%-74% of G34-DHG <ref name=":1" /><ref name=":4" />
|70%-74% of G34-DHG <ref name=":1" /><ref name=":4" />
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*DNA methylation and gene expression profiling can be used to differentiate G34-DHG with other glioma subgroups.
*DNA methylation and gene expression profiling can be used to differentiate G34-DHG with other glioma subgroups.
*''MGMT'' promoter methylation can be assessed by methylation specific polymerase chain reaction analysis (bisulfite treated DNA undergoes real-time PCR)<br />
*''MGMT'' promoter methylation can be assessed by methylation specific polymerase chain reaction analysis (bisulfite treated DNA undergoes real-time PCR)<br />
==Familial Forms==
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==Additional Information==
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==Links==
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==References==
==References==
Retrieved from "https://test.ccga.io/index.php/CNS5:Diffuse_hemispheric_glioma,_H3_G34-mutant"