HAEM5:Splenic diffuse red pulp small B-cell lymphoma: Difference between revisions
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{{Under Construction}} | {{Under Construction}} | ||
<blockquote class='blockedit'>{{Box-round|title=HAEM5 Conversion Notes|This page was converted to the new template on 2023- | <blockquote class='blockedit'>{{Box-round|title=HAEM5 Conversion Notes|This page was converted to the new template on 2023-12-04. The original page can be found at [[HAEM4:Splenic Diffuse Red Pulp Small B-cell Lymphoma]]. | ||
}}</blockquote> | }}</blockquote> | ||
==Primary Author(s)*== | ==Primary Author(s)*== | ||
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==Cancer Category / Type== | ==Cancer Category / Type== | ||
*[[Mature B-Cell Neoplasms|Mature B-Cell Neoplasm]] | *[[HAEM4:Mature B-Cell Neoplasms|Mature B-Cell Neoplasm]] | ||
==Cancer Sub-Classification / Subtype== | ==Cancer Sub-Classification / Subtype== | ||
*[[Splenic B-cell Lymphoma/Leukemia, Unclassifiable]] | *[[HAEM4:Splenic B-cell Lymphoma/Leukemia, Unclassifiable]] | ||
==Definition / Description of Disease== | ==Definition / Description of Disease== | ||
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|BRAF p.Val600Glu | |BRAF p.Val600Glu | ||
|Possible role in diagnosis (exclusion) | |Possible role in diagnosis (exclusion) | ||
|Prevalent in [[Hairy | |Prevalent in [[HAEM5:Hairy cell leukaemia|HCL]] but rare/absent in SDRPL<ref name=":3" /> | ||
|- | |- | ||
|MAP2K1 | |MAP2K1 | ||
|Possible role in diagnosis (exclusion) | |Possible role in diagnosis (exclusion) | ||
|Prevalent in [[Hairy | |Prevalent in [[HAEM5:Hairy cell leukaemia Variant|HCL-v]] and a subset of cases classified as [[HAEM5:Hairy cell leukaemia|HCL]] but uncommon in SDRPL<ref name=":3" /> | ||
|- | |- | ||
|KLF2 and TNFAIP3 | |KLF2 and TNFAIP3 | ||
|Possible role in diagnosis (exclusion) | |Possible role in diagnosis (exclusion) | ||
|Prevalent in [[Splenic | |Prevalent in [[HAEM5:Splenic marginal zone lymphoma|SMZL]] but rare/absent in SDRPL<ref name=":3" /> | ||
|- | |- | ||
|MYD88 | |MYD88 | ||
|Possible role in diagnosis (exclusion) | |Possible role in diagnosis (exclusion) | ||
|Prevalent in [[Lymphoplasmacytic | |Prevalent in [[HAEM5:Lymphoplasmacytic lymphoma|LPL]] and [[HAEM5:Splenic marginal zone lymphoma|SMZL]] but rare/absent in SDRPL<ref name=":3" /> | ||
|- | |- | ||
|BCOR | |BCOR | ||
|Possible role in diagnosis (inclusion) | |Possible role in diagnosis (inclusion) | ||
|Prevalent in SDRPL but rare/absent in [[Hairy | |Prevalent in SDRPL but rare/absent in [[HAEM5:Hairy cell leukaemia|HCL]], [[HAEM5:Hairy cell leukaemia Variant|HCL-v]], and [[HAEM5:Splenic marginal zone lymphoma|SMZL]]<ref name=":3" /> | ||
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*SDRPL is a provisional WHO entity and definitive diagnostic criteria have not been determined | *SDRPL is a provisional WHO entity and definitive diagnostic criteria have not been determined | ||
**Diagnosis of exclusion | **Diagnosis of exclusion | ||
***Differential of splenic lymphomas with cytoplasmic projections: [[Hairy | ***Differential of splenic lymphomas with cytoplasmic projections: [[HAEM5:Hairy cell leukaemia|HCL]], [[HAEM5:Hairy cell leukaemia Variant|HCL-v]], [[HAEM5:Splenic marginal zone lymphoma|SMZL]] | ||
**Distinction is by clinical history, morphology, and immunohistochemistry | **Distinction is by clinical history, morphology, and immunohistochemistry | ||
***No pathognomonic diagnostic markers (molecular or otherwise) | ***No pathognomonic diagnostic markers (molecular or otherwise) | ||
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==Links== | ==Links== | ||
*[[Hairy | *[[HAEM5:Hairy cell leukaemia]] | ||
*[[Hairy | *[[HAEM5:Hairy cell leukaemia Variant]] | ||
*[[Splenic B-cell Lymphoma/Leukemia, Unclassifiable]] | *[[HAEM4:Splenic B-cell Lymphoma/Leukemia, Unclassifiable]] | ||
*[[Splenic | *[[HAEM5:Splenic marginal zone lymphoma]] | ||
==References== | ==References== | ||