HAEM5:Primary cutaneous marginal zone lymphoma: Difference between revisions

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 !Finding!!Marker
+|-
+|Positive
+|CD20
+|-
+|Positive
+|CD22
+|-
+|Positive
+|CD79a
 |-
 |Positive||BCL2
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 |}
-*The reactive germinal centers B cells are BCL6 positive and BCL2 negative.
+* Associated reactive germinal centers B cells
-*CD123 positive plasmacytoid dendritic cells.
+** BCL6 positive
-*Plasma cells have monotypic expression of immunoglobulin light chains often. Heavy chain class-switched form IgG, IgA, or IgE and have no expression of CXCR3. If non-class-switched forms are present, IgM and CXCR3 are expressed.
+** BCL2 negative
-**Approximately 90% of cases have IgG, IgA, or IgE positivity
+*Plasmacytoid dendritic cells
-**Approximately 10% of cases have IgM positivity
+**CD123 positive
-*IgG4 expressed by plasma cells in 13-35% of cases, though not related to IgG4-related disease.
+*Plasma cells
+**CD138 and CD79a positive
+**Plasma cells often have monotypic expression of immunoglobulin light chains
+**The immunoglobulin heavy chain can be either non-class-switched or class-switched
+***Non-class-switched heavy chain
+****Produce IgM
+****Positive for CXCR3 expression
+****Approximately 10% of cases have IgM positivity
+***Class-switched heavy chain
+****Produce IgG, IgA, or IgE
+****No expression of CXCR3
+****Approximately 90% of cases have IgG, IgA, or IgE positivity
+**IgG4 expressed by plasma cells in 13-35% of cases, though not related to IgG4-related disease.
 ==Chromosomal Rearrangements (Gene Fusions)==
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 ==Additional Information==
-* Favorable prognosis
+*Favorable prognosis
-** 5-year disease-specific survival rate >98%
+**5-year disease-specific survival rate >98%
-* Recurrence is common
+*Recurrence is common
-* 4% of patients will have extracutaneous spread, particularly in patients with longstanding multifocal disease
+*4% of patients will have extracutaneous spread, particularly in patients with longstanding multifocal disease
 ==Links==