HAEM5:Follicular lymphoma: Difference between revisions

[unchecked revision][unchecked revision]
mNo edit summary
Line 114: Line 114:




<blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}[1, 2, 3, 4]</blockquote>
==Immunophenotype==
==Immunophenotype==




Typical FL has CD10+, BL2+.  Atypical FL subgroups CD10- and/or BCL2 - all FL are STMN+ - useful differentiator between atypical FL and MZL [9]
Typically, FL is CD10+, BL2+.  Atypical FL subgroups CD10- and/or BCL2 - all FL are STMN+ - useful differentiator between atypical FL and MZL [9]


{| class="wikitable sortable"
{| class="wikitable sortable"
Line 134: Line 133:




<blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}[1, 9, 10]</blockquote>
==Chromosomal Rearrangements (Gene Fusions)==
==Chromosomal Rearrangements (Gene Fusions)==


Put your text here and fill in the table
<br />


{| class="wikitable sortable"
{| class="wikitable sortable"
Line 147: Line 145:
!Notes
!Notes
|-
|-
|EXAMPLE t(9;22)(q34;q11.2)||EXAMPLE 3'ABL1 / 5'BCR||EXAMPLE der(22)||EXAMPLE 20% (COSMIC)
|t(14;18)(q32;q21)||5' IGH / 3' BCL2||der(18)||80%~90%
EXAMPLE 30% (add reference)
|Yes
|No
|No
|Yes
|No
|EXAMPLE
|No
 
|Rarely, BCL2 rearrangement may also be observed with IGK at 2p11.2 or IGL at 22q11.22.
The t(9;22) is diagnostic of CML in the appropriate morphology and clinical context (add reference). This fusion is responsive to targeted therapy such as Imatinib (Gleevec) (add reference).
|}
|}