HAEM5:Myelodysplastic/myeloproliferative neoplasm with neutrophilia: Difference between revisions
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{{DISPLAYTITLE:Myelodysplastic/myeloproliferative neoplasm with neutrophilia}} | {{DISPLAYTITLE:Myelodysplastic/myeloproliferative neoplasm with neutrophilia}} | ||
[[HAEM5:Table_of_Contents|Haematolymphoid Tumours (WHO Classification, 5th ed.)]] | [[HAEM5:Table_of_Contents|Haematolymphoid Tumours (WHO Classification, 5th ed.)]] | ||
{{Under Construction}} | {{Under Construction}} | ||
<blockquote class= | <blockquote class="blockedit">{{Box-round|title=Content Update To WHO 5th Edition Classification Is In Process; Content Below is Based on WHO 4th Edition Classification|This page was converted to the new template on 2023-12-07. The original page can be found at [[HAEM4:Atypical Chronic Myeloid Leukemia (aCML), BCR-ABL1 Negative]]. | ||
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==WHO Essential and Desirable Genetic Diagnostic Criteria== | ==WHO Essential and Desirable Genetic Diagnostic Criteria== | ||
<span style="color:#0070C0">(''Instructions: The table will have the diagnostic criteria from the WHO book <u>autocompleted</u>; remove any <u>non</u>-genetics related criteria. If applicable, add text about other classification'' ''systems that define this entity and specify how the genetics-related criteria differ.'')</span> | <span style="color:#0070C0">(''Instructions: The table will have the diagnostic criteria from the WHO book <u>autocompleted</u>; remove any <u>non</u>-genetics related criteria. If applicable, add text about other classification'' ''systems that define this entity and specify how the genetics-related criteria differ.'')</span> | ||
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<blockquote class= | <blockquote class="blockedit">{{Box-round|title=v4:Chromosomal Rearrangements (Gene Fusions)|The content below was from the old template. Please incorporate above.}}</blockquote> | ||
None. | None. | ||
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<blockquote class= | <blockquote class="blockedit">{{Box-round|title=v4:Clinical Significance (Diagnosis, Prognosis and Therapeutic Implications).|Please incorporate this section into the relevant tables found in: | ||
* Chromosomal Rearrangements (Gene Fusions) | * Chromosomal Rearrangements (Gene Fusions) | ||
* Individual Region Genomic Gain/Loss/LOH | * Individual Region Genomic Gain/Loss/LOH | ||
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The prognostic value of molecular/genetic abnormalities are not well studied yet. | The prognostic value of molecular/genetic abnormalities are not well studied yet. | ||
Approximately 20-40% of aCML evolves to [[AML|acute myeloid leukemia]]<ref name=":0" />; most of the remaining patients die of marrow failure<ref name=":3" /><ref name=":4">{{Cite journal|last=M|first=Breccia|last2=F|first2=Biondo|last3=R|first3=Latagliata|last4=I|first4=Carmosino|last5=F|first5=Mandelli|last6=G|first6=Alimena|date=2006|title=Identification of Risk Factors in Atypical Chronic Myeloid Leukemia|url=https://pubmed.ncbi.nlm.nih.gov/17043019/|language=en|pmid=17043019}}</ref>. | Approximately 20-40% of aCML evolves to [[AML|acute myeloid leukemia]]<ref name=":0">{{Cite journal|last=Sa|first=Wang|last2=Rp|first2=Hasserjian|last3=Ps|first3=Fox|last4=Hj|first4=Rogers|last5=Jt|first5=Geyer|last6=D|first6=Chabot-Richards|last7=E|first7=Weinzierl|last8=J|first8=Hatem|last9=J|first9=Jaso|date=2014|title=Atypical Chronic Myeloid Leukemia Is Clinically Distinct From Unclassifiable Myelodysplastic/Myeloproliferative Neoplasms|url=https://pubmed.ncbi.nlm.nih.gov/24627528/|language=en|doi=10.1182/blood-2014-02-553800|pmc=PMC4067498|pmid=24627528}}</ref>; most of the remaining patients die of marrow failure<ref name=":3">{{Cite journal|last=R|first=Kurzrock|last2=Ce|first2=Bueso-Ramos|last3=H|first3=Kantarjian|last4=E|first4=Freireich|last5=Sl|first5=Tucker|last6=M|first6=Siciliano|last7=S|first7=Pilat|last8=M|first8=Talpaz|date=2001|title=BCR Rearrangement-Negative Chronic Myelogenous Leukemia Revisited|url=https://pubmed.ncbi.nlm.nih.gov/11387365/|language=en|pmid=11387365}}</ref><ref name=":4">{{Cite journal|last=M|first=Breccia|last2=F|first2=Biondo|last3=R|first3=Latagliata|last4=I|first4=Carmosino|last5=F|first5=Mandelli|last6=G|first6=Alimena|date=2006|title=Identification of Risk Factors in Atypical Chronic Myeloid Leukemia|url=https://pubmed.ncbi.nlm.nih.gov/17043019/|language=en|pmid=17043019}}</ref>. | ||
Predictors of worse prognosis: | Predictors of worse prognosis: | ||
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<blockquote class= | <blockquote class="blockedit">{{Box-round|title=v4:Genomic Gain/Loss/LOH|The content below was from the old template. Please incorporate above.}}</blockquote> | ||
Karyotypic abnormalities are reported in as many as 80% of cases. | Karyotypic abnormalities are reported in as many as 80% of cases. | ||
*Trisomy 8 and del(20q) most common. | *Trisomy 8 and del(20q) most common. | ||
*Abnormalities of chromosomes 13, 14, 17, 19 and 12 are also common <ref name=":1" /><ref name=":2" />. | *Abnormalities of chromosomes 13, 14, 17, 19 and 12 are also common <ref name=":1">{{Cite journal|last=Jm|first=Hernández|last2=Mc|first2=del Cañizo|last3=A|first3=Cuneo|last4=Jl|first4=García|last5=Nc|first5=Gutiérrez|last6=M|first6=González|last7=G|first7=Castoldi|last8=Jf|first8=San Miguel|date=2000|title=Clinical, Hematological and Cytogenetic Characteristics of Atypical Chronic Myeloid Leukemia|url=https://pubmed.ncbi.nlm.nih.gov/10847463/|language=en|pmid=10847463}}</ref><ref name=":2">{{Cite journal|last=P|first=Martiat|last2=Jl|first2=Michaux|last3=J|first3=Rodhain|date=1991|title=Philadelphia-negative (Ph-) Chronic Myeloid Leukemia (CML): Comparison With Ph+ CML and Chronic Myelomonocytic Leukemia. The Groupe Français De Cytogénétique Hématologique|url=https://pubmed.ncbi.nlm.nih.gov/2070054/|language=en|pmid=2070054}}</ref>. | ||
*Isolated isochromosome 17q rare (most present with features of [[HAEM5:Chronic myelomonocytic leukaemia|CMML]] instead of aCML). | *Isolated isochromosome 17q rare (most present with features of [[HAEM5:Chronic myelomonocytic leukaemia|CMML]] instead of aCML). | ||
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<blockquote class= | <blockquote class="blockedit">{{Box-round|title=v4:Characteristic Chromosomal Aberrations / Patterns|The content below was from the old template. Please incorporate above.}}</blockquote> | ||
None. | None. | ||
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|}Note: A more extensive list of mutations can be found in [https://www.cbioportal.org/ <u>cBioportal</u>], [https://cancer.sanger.ac.uk/cosmic <u>COSMIC</u>], and/or other databases. When applicable, gene-specific pages within the CCGA site directly link to pertinent external content. | |}Note: A more extensive list of mutations can be found in [https://www.cbioportal.org/ <u>cBioportal</u>], [https://cancer.sanger.ac.uk/cosmic <u>COSMIC</u>], and/or other databases. When applicable, gene-specific pages within the CCGA site directly link to pertinent external content. | ||
<blockquote class= | <blockquote class="blockedit">{{Box-round|title=v4:Gene Mutations (SNV/INDEL)|The content below was from the old template. Please incorporate above.}}</blockquote> | ||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
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<blockquote class= | <blockquote class="blockedit">{{Box-round|title=v4:Genes and Main Pathways Involved|The content below was from the old template. Please incorporate above.}}</blockquote> | ||
Frequently involved: | Frequently involved: | ||
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(use the "Cite" icon at the top of the page) <span style="color:#0070C0">(''Instructions: Add each reference into the text above by clicking where you want to insert the reference, selecting the “Cite” icon at the top of the wiki page, and using the “Automatic” tab option to search by PMID to select the reference to insert. If a PMID is not available, such as for a book, please use the “Cite” icon, select “Manual” and then “Basic Form”, and include the entire reference. To insert the same reference again later in the page, select the “Cite” icon and “Re-use” to find the reference; DO NOT insert the same reference twice using the “Automatic” tab as it will be treated as two separate references. The reference list in this section will be automatically generated and sorted''</span><span style="color:#0070C0">''.''</span><span style="color:#0070C0">)</span> <references /> | (use the "Cite" icon at the top of the page) <span style="color:#0070C0">(''Instructions: Add each reference into the text above by clicking where you want to insert the reference, selecting the “Cite” icon at the top of the wiki page, and using the “Automatic” tab option to search by PMID to select the reference to insert. If a PMID is not available, such as for a book, please use the “Cite” icon, select “Manual” and then “Basic Form”, and include the entire reference. To insert the same reference again later in the page, select the “Cite” icon and “Re-use” to find the reference; DO NOT insert the same reference twice using the “Automatic” tab as it will be treated as two separate references. The reference list in this section will be automatically generated and sorted''</span><span style="color:#0070C0">''.''</span><span style="color:#0070C0">)</span> <references /> | ||
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==Notes== | ==Notes== | ||
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<nowiki>*</nowiki>''Citation of this Page'': “Myelodysplastic/myeloproliferative neoplasm with neutrophilia”. Compendium of Cancer Genome Aberrations (CCGA), Cancer Genomics Consortium (CGC), updated {{REVISIONMONTH}}/{{REVISIONDAY}}/{{REVISIONYEAR}}, <nowiki>https://ccga.io/index.php/HAEM5:Myelodysplastic/myeloproliferative_neoplasm_with_neutrophilia</nowiki>. | <nowiki>*</nowiki>''Citation of this Page'': “Myelodysplastic/myeloproliferative neoplasm with neutrophilia”. Compendium of Cancer Genome Aberrations (CCGA), Cancer Genomics Consortium (CGC), updated {{REVISIONMONTH}}/{{REVISIONDAY}}/{{REVISIONYEAR}}, <nowiki>https://ccga.io/index.php/HAEM5:Myelodysplastic/myeloproliferative_neoplasm_with_neutrophilia</nowiki>. | ||
[[Category:HAEM5]][[Category:DISEASE]][[Category:Diseases M]] | [[Category:HAEM5]] | ||
[[Category:DISEASE]] | |||
[[Category:Diseases M]] | |||